Frontiers of Longevity Science, Vol. 1

This is the first volume of a three-volume series on Frontiers of Longevity Science . The series unites global experts to map the rapidly expanding field of longevity medicine. Co-edited by David Barzilai, Max Rangeley, Regina R. Monaco, and David Wood, the series bridges molecular mechanisms, translational innovation, economics, and policy. Contributors from geroscience and the social sciences debate a central question: can we merely slow age-related diseases, or can the biology of aging itself be fundamentally changed?

Volume 1, The Biology of Life Extension , examines the root mechanisms of aging. From evolutionary theories to the cellular hallmarks driving degeneration, leading researchers explore cutting-edge strategies to intervene directly in the aging process. Topics include damage repair, organ replacement, genetic medicine, senotherapeutics, and cellular reprogramming. These chapters map the scientific foundation that could transform extended longevity from an aspiration into an engineered reality.