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Targeting Chronic Inflammatory Lung
Diseases Using Advanced Drug Delivery S

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Woodhead Publishing Series in Biomaterials

Engineered Biomaterials for Drug Delivery covers a core selection of engineering approaches and methods to optimize materials for drug delivery, including grafting, cross-linking, thiolation, conjugation, and the functionalization of biomaterials. A wide range of engineered biomaterial types are described, from biopolymers and nanobiomaterials, to metals, ceramics, and composites. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

Engineered Biomaterials for Drug Delivery

This valuable reference for advanced students and practicing engineers provides a comprehensive overview of low transformation temperature (LTT) welding materials, detailing their design, properties, and weldability, and demonstrating their applications in preventing fatigue and improving corrosion performance in welded structures. Through this book, readers will gain a comprehensive understanding of how LTT actively controls welding residual stress to improve the fatigue life of welded structures and raise corrosion resistance. The book first provides a review of LTT welding materials, addressing the design of chemical compositions for LTT welding materials, the properties and weldability of LTT welding materials, compressive residual stress, and stress concentration, while providing practical application examples of LTT welding materials for preventing fatigue cracking. The authors provide experimental and numerically simulated data, photos, graphs, and tables to illustrate the information within the book and facilitate readers' understanding. Last, the book discusses practical applications such as the successful prevention of fatigue cracks at the toe of fillet welds (such as boxed fillet welds in ship structures) or surface coating using wire-arc additive manufacturing to improve corrosion performance. These application descriptions are supported with an appendix supplying digital data of LTT material properties and finite element mesh data for butt and fillet welds. This practical information will allow readers to apply this knowledge in real-world scenarios and also develop and extend the number of applications for LTT welding materials, contributing to improved corrosion performance in welded structures. Upper undergraduate and postgraduate students will find this a valuable aid to their learning as it provides additional information to supplement course materials. Practitioners will also benefit from the practical information including simulation and real-world data that will benefit their daily work.

Properties, Weldability and Active Applications

Low Transformation Temperature Welding Materials

Micro & Nano Technologies

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy explores the innovative use of biocompatible, multifunctional nanoplatforms to target mitochondria for selective drug delivery, enhancing treatment efficacy while minimizing side effects. The book provides a comprehensive overview of the role of nanotechnology in cancer treatment, reviewing the basics of nanotechnology and cancer biology, advanced nanoengineering strategies, and the development of mitochondria-targeted drug delivery systems, such as liposomal therapies, photosensitizer nanoparticles, and peptides for cancer treatment, along with strategies to modulate mitochondrial functions using nanomaterials. This is a valuable resource to researchers and scientists interested in the application of nanotechnology for improved cancer therapy as it provides a thorough overview of real-world applications and future research trends as well as a discussion on overcoming challenges in mitochondrial targeting.

Mitochondria-targeted Drug Delivery Strategies for Cancer Therapy

Overview of a technique for trapping and manipulation of micro and nanoparticles with light, sound, temperature gradients, and electric fields Optoelectronic Tweezers for Manipulation at the Micro and Nano Scale takes readers on a journey to explore the fascinating world of Optoelectronic Tweezers (OET) and their applications in micro- and nano-scale manipulation. Starting from the evolution of nanotechnology, this book delves into the development of optical micromanipulation technologies such as Optical Tweezers (OT) and the emergence of OET as a cutting-edge technology with superior performance in various aspects. The fundamental principles of OET, its significance, and diverse applications across different fields are meticulously examined. This book covers the working mechanisms, operational principles, optical foundations, photovoltaic effects, and material selection processes in OET technology. Detailed insights into the components of OET devices, including standard OET and photovoltaic OET, are provided, along with a comprehensive analysis of manipulation forces and dielectrophoretic effects within OET chips. Written by a highly qualified researcher and author in the field, Optoelectronic Tweezers for Manipulation at the Micro and Nano Scale includes information on: <ul><li>Practical applications of OET in biomedical fields, showcasing its efficacy in cell sorting, trapping, lysis, patterning, immunoreaction analysis, DNA transfection, and other crucial biological processes</li> <li>Versatility of OET in manipulating a myriad of micro and nano objects, ranging from living organisms like cells and bacteria to non-living entities such as nanoparticles and microspheres</li> <li>Integration of OET with complementary technologies like microfluidics, photocuring, electrowetting, and image recognition</li> <li>Interplay of optical principles, light sources, and photovoltaic mechanisms in OET setups</li></ul> Providing deep knowledge into the boundless opportunities offered by OET technology, Optoelectronic Tweezers for Manipulation at the Micro and Nano Scale is an excellent reference on the subject for materials scientists, thermodynamics physicists, and laser specialists, along with all professionals in the optical industry.

Optoelectronic Tweezers for Manipulation at the Micro and Nano Scale

Previously known as Drafting Agreements in the Biotechnology and Pharmaceutical Industries, this title provides precedent agreements for the main types of commercial transaction encountered in the life sciences, biotechnology and pharmaceutical industries. In addition to the print version, each precedent is available via an accompanying website in a format which can be easily downloaded and edited. Detailed commentary on legal, commercial and practice issues accompanies every precedent. Provided by specialist lawyers from across Europe, this commentary also highlights important differences between English law and that of other key EU jurisdictions: Germany, France, the Netherlands, Spain and Sweden. Commentary on specific considerations for the US is also provided. In addition to precedent commentaries, the book also contains detailed commentary and discussion of legal issues common to the life sciences, biotechnology and pharmaceutical industries, as well as links to relevant materials (eg regulatory materials on clinical trials). This title is included in Bloomsbury Professional's Intellectual Property and IT online service.

Drafting Agreements in Life Sciences

Sustainability in Latin America: A Bioeconomic Approach explores the bioeconomy through theories, methodologies, and case studies rooted in specific contexts across Latin America. Rather than attempting to compile or generalize a singular vision of a Latin American bioeconomy, it highlights diverse experiences that reflect the region’s complexity. By its very nature, the bioeconomy is both multidisciplinary and interdisciplinary. Accordingly, the book features contributions from various fields, offering a rich, multifaceted understanding of bioeconomic practices. For instance, Chapter 1 revisits Georgescu-Roegen’s theory through a fresh lens, enriched by new multidisciplinary insights into territorial and sociocultural dynamics. This approach opens up possibilities for rethinking consumption patterns, fostering sustainable technologies, and strengthening community development.

A Bioeconomic Approach

Sustainability in Latin America

Plant Chemistry

Plant Enzyme Systems and Their Biochemical and Environmental Interactions

“The choice to invest in vaccines rather than in weapons; in treatments for rare diseases rather than in speculative consumer products; in long-term infrastructure rather than in short-term optics—these are not technical decisions. They are moral decisions . . .” Biotech in the Balance by Dr. Jeremy M. Levin shows why the next lifesaving medicines may not arrive on time, and what we can do about that in a period of political change. This is not a technical book. It is a bedside-to-boardroom story, told from inside the system, with a clear map of what has to change so that medicines keep arriving when people need them. When funding for research and development is politicized, trust in science erodes and the foundations of biotechnology weaken. When science is treated as a partisan symbol rather than a shared foundation for health, patients and families bear the consequences. Dr. Levin’s career began as a scientist studying the structure of DNA, and then as a physician in university hospitals in London, Cape Town, and Geneva. As a doctor, he saw the difference between patients saved by medicines that arrived just in time, and those who were not so fortunate. That experience led to a simple conviction: drug discovery and development is not an abstract business. It is a living coalition of scientists, governments, businesses, and—above all—patients. For patients and their families, profitability and internal strategy are not the point. What matters is whether a therapy works, how quickly results can be seen, and how benefits are weighed against risks—including the risk of doing nothing. Throughout the book, Dr. Levin keeps patients at the center of the discussion—politics, markets, supply chains, and governance—and shows how each of these forces can accelerate or delay medical progress. Written from the perspective of a scientist and physician, Biotech in the Balance argues for a resilient, globally competitive biotechnology industry built to serve patients and earn lasting public trust. It offers a call to action for preserving biotechnology as a strategic asset—and a practical framework for leaders who want to strengthen the system rather than merely defend it.

Saving a Strategic Industry in an Age of Distrust

Biotech in the Balance

A road map for developing responsible and innovative governance systems based on generative AI and other exponential technologiesAs exponential technology rapidly advances, leaders in every sector are faced with the challenge of harnessing its potential power while developing precautionary safeguards against its risks. From generative artificial intelligence to the future of quantum computing, these innovations are transforming the world at an unprecedented rate, leaving decision-makers unsure of how to maintain control and ensure responsible development.Governing Pandora focuses on multiple exponential technologies in order to demonstrate how leaders can develop responsible and innovative governance systems. This book equips leaders with frameworks and tools-including a detailed five-element "exponential governance mind-set"--to develop a more holistic tech governance approach for current and future waves of exponential tech. Andrea Bonime-Blanc encourages the development of a culture of collaboration across borders, sectors, and disciplines as technology takes on a bigger role in our ecosystem. She explains the context, risks, and opportunities of the ongoing exponential technology revolution so that leaders can futureproof themselves, their organizations, and key stakeholders with strategies and tactics to act responsibly, ethically, and successfully.This book speaks directly to executives, board members, policymakers, and organizational leaders who are tasked with charting a course through the advancement of modern technologies. Governing Pandora bridges the gap between exploring pure technology and managing and governing applied technology. Readers will learn not only how to develop a governance mind-set for exponential technology but also how to build organizational resilience.

Leading in the Age of Generative AI and Exponential Technology

Governing Pandora

AI-Powered Drug Delivery to Neuro and Cardiovascular Systems: Perspectives and Future Challenges is a definitive reference exploring the transformative influence of Artificial Intelligence (AI) in neuro and cardiovascular drug delivery. This book integrates cutting-edge research to explain how AI is poised to reshape clinical protocols, therapeutic strategies, and regulatory standards. By examining advancements in robotics and intelligent systems, it demonstrates how AI enhances precision, personalization, and efficiency in drug delivery for heart and neurological conditions, providing readers with a thorough understanding of these innovations and their potential to revolutionize healthcare practices. The book delves into AI-driven drug design and testing for cardiovascular diseases and explores the application of AI in cardiac drug delivery vehicles. It discusses bioengineered heart and vessel therapeutics, redox homeostasis, and targeted drug replenishment in cardiac matrix remodeling. Additionally, it addresses mitochondrial drug retention, AI-assisted gene therapy for neurodegenerative disorders, and the role of AI in optimizing heart health. The text highlights smart systems for managing cerebrovascular accidents and neuromodulation with pharmacotherapy. Finally, it covers translational challenges, future directions, and the significance of AI-driven prediction models and robotic delivery mechanisms.

Perspectives and Future Challenges

AI Powered Drug delivery to Neuro and Cardiovascular Systems

Principles and Practice

Cement Production Technology

Topical Dermal Drug Delivery: Concepts and Advances compiles, in a single volume, the most recent advances in topical and dermal formulations for the treatment of skin disorders. The book covers three major concepts. The skin anatomy and physiology part includes chapters focused on relevant information for drug delivery. The second part of the book deals with several recent topical dermal drug delivery systems, including computational methods, permeation enhancers, bio precursors, hydrogels, emugels, exosomes and several nanotechnology enabled systems. The third and final part covers scaling up, toxicity, clinical trials, and regulatory considerations. This is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the skin. Medical &amp; Health Sciences researchers would also benefit from understanding the delivery systems covered in this book.

Concepts and Advances

Topical Dermal Drug Delivery

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

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