To do so, the book examines legitimacy management in the context of two real-world hybrid organizations – the Swiss Institute for Translational and Entrepreneurial Medicine and the Swiss Center for Design and Health in Bern, Switzerland – from both theoretical and practical perspectives. It shows why the systematic combination of three types of legitimacy has the potential to optimize the level of legitimacy in emerging hybrids, contributing to their success. It also explains how organizational legitimacy can be operationalized using governance legitimacy, purpose-rational legitimacy, and value-rational legitimacy.