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Pal A: Mitochondrial Genomics in Health
and Diseases

Mitochondrial Genomics in Health and Diseases

Genomic and Precision Medicine in Clinical Practice

Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region. Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

Medical and Health Genomics of South Asia

International Texts in Developmental Psychology

Insights from Genetics and Epigenetics

Psychobiological Development

Practical Bioinformatics

Methods in Cell Biology

Advanced Cancer Research Protocols: Volume 198

Progress in Molecular Biology and Translational Science

Design and Applications of Cell-Free Systems: Volume 218

Cases that Changed the World

The Secrets of our DNA

New York Times bestselling author and former FDA Commissioner Scott Gottlieb provides a glimpse of a promising future that is quickly approaching: a world with cures for chronic illnesses and cancers. While traditional drugs mostly help us manage the effects of disease, cell therapies promise genuine cures for a broad range of intractable ailments, from Alzheimer's to heart damage to cancer. They could even reverse the effects of aging. For the first time in history, on an unprecedented scale, we possess the power to modify the biology that gives rise to disease, ultimately restoring individuals to a state of normalcy and reversing debilitating ailments. In The Miracle Century, former FDA Commissioner Scott Gottlieb traces the scientific achievements that propelled progress in cell therapies. The birth of this medical revolution wasn't a sudden event. Rather, it emerged from decades of steady, incremental progress in science. These concerted advances made cell therapies a reality. To forge a path for continued medical breakthroughs, Dr. Gottlieb meticulously traces this scientific journey, identifying lessons on how these achievements can be replicated. The MIracle Century is a look at the future of healthcare from one of the nation's leading medical authorities. Scott Gottlieb explains how these new medicines are moving from the laboratory bench to the marketplace and tackles the issues that must be addressed to enable wide adoption of these treatments and transform as many lives as possible.

Making Sense of the Cell Therapy Revolution

The Miracle Century

Cryo-EM Methods and Management

Transformation from Globular Proteins to Amyloids

Simulating Protein Folding in Variable Environmental Conditions

The Weird and Wonderful Science of How our Planet is Populated

The Evolution of Sex

Globally, there are numerous infectious diseases, normally found in vertebrates other than humans, that have been documented to be transmitted to humans and cause human infections. These "zoonotic infections" are the topic of this book.This book is arranged to have chapters by the type of animal. Within each chapter is information on the animal(s), the normal flora of the animal(s), and the diseases that have been transmitted from this group of animals by bites and/or scratches, contact (including transmission via ectoparasites such as fleas and ticks), ingestion of the animal, and other documented transmission, such as infestation by members of the genus Sarcoptes as has been documented in humans exposed to dogs with "mange," in "cavalryman itch" from horses, from contact with dromedaries, etc.There are a number of additional issues that takeoff from a fundamental knowledge of zoonotic infections. These include a working knowledge of many of the agends of bioterrorism, as the events of 2001 demonstrated of the use of Bacillus anthracis spores in mailed letters. Another area of importance is that of emerging infections. An analysis of 335 origins of emerging infectious diseases between 1940 and 2004 revealed that these are dominated by infections that are zoonotic in origin, comprising some 60.3% of the emerging infections. Of these, 71.8% originated in wildlife.Given the importance of this topic in our understanding of infectious disease, a timely source is a necessary addition to the current available literature

Zoonoses: Animal Exposure and Human Disease

Debating the use of genomic tools and their societal impactOver the past decade, the field of human genetics has produced an extraordinary range of discoveries-including the refinement of polygenic scores, which use a person's DNA to estimate their likelihood of developing a trait or disease. But are these new technologies ready to leave the research lab and be deployed in schools, fertility clinics, and the wider world? In What We Inherit, Sam Trejo and Daphne Martschenko offer different perspectives on the societal impact of the rapidly unfolding DNA revolution. Trejo, a sociologist and expert on the complex ways people's genes influence their life's trajectory, believes that new genomic tools-if used thoughtfully-can improve society; Martschenko, a bioethicist who specializes in the thorny social issues raised by biomedical advances, is more cautious. They debate both the risks and the opportunities posed by such new technologies as at-home genetic tests and polygenic embryo selection-all while engaging in a wide-ranging dialogue on ideology, biology, and social inequality. While grappling with these new technologies, Trejo and Martschenko remind us that we inherited from our ancestors not only DNA but also wrong-headed ideas about genes. Together, they caution against two particularly harmful genetic myths: that genes determine an individual's future, and that race and genetics are inherently connected. A polygenic score, for example, is not a definitive marker for disease. And race is a sociopolitical construct, not a biological identity. Trejo and Martschenko argue that, to avoid exacerbating social inequality, we need to begin regulating genomic tools sooner rather than later.

How New Technologies and Old Myths Are Shaping Our Genomic Future

What We Inherit

Mitochondrial Genomics in Health and Diseases

Informations bibliographiques

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