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Cryo-EM Methods and Management

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

Structural Biology of Amyloid Fibrils

Advances in Clinical Chemistry

Advances in Clinical Chemistry: Volume 126

Methods in Molecular and Materials Modelling

Methods in Biomolecular Modelling, Volume Two in the series, considers modeling methods with relevance to the study of biomolecular systems, including the workhorse of classical molecular dynamics and related techniques, areas where electronic structure methods find use, the higher length scales achievable through coarse grained and mesoscale methods, and combinations of scales. Applicability of methods is then illustrated with a wide range of biomolecular modeling research topics drawn from current research. Throughout the text, practical considerations of research are emphasized, including sourcing of structural data, scalability of methods on HPC systems, and linking of computation to experiment. Part I introduces a range of modeling techniques used for biomolecular simulation, explaining the fundamental principles of each and the research areas to which they are applicable. The strengths and weaknesses of each method are outlined, along with their real-world performance on current computing resources and future trends. Part II looks at a range of application areas, with case studies illustrating the methods that can be used to investigate biomolecular systems in these areas.

Methods in Biomolecular Modelling

Foundations and Frontiers in Enzymology

Cryptic Enzymes and Moonlighting Proteins, a new volume in the Foundations and Frontiers in Enzymology series, offers a thorough overview of cryptic enzymes and moonlighting proteins in signaling cascades. In early chapters, leading international contributors discuss evolutionary considerations for moonlighting proteins, moonlighting interactions in the extracellular matrix, eukaryotic moonlighting proteins, modulating, moonlighting kinases, moonlighting proteins in neurobiology signaling, metabolic enzymes moonlighting as RNA binding and regulatory proteins. Later, methods-driven chapters discuss practical aspects of identifying hidden moonlighting domains in proteins, computational approaches and bioinformatic tools for the identification of cryptic enzymes, establishing cryptic enzyme interactomes, and assessing contributions of moonlighting proteins to signal cascades. The book also explores recent advances in research and brings together an array of information across different fields to enable better targeting of these exciting proteins and their interactomes. With a clear focus on the role of moonlighting and cryptic enzymes in signal transduction, users will find examples of cryptic enzymes across species, as well as those in human healthy biology and pathogenesis.

Cryptic Enzymes and Moonlighting Proteins

Advances in Clinical Chemistry: Volume 125

Plant Biology, sustainability and climate change

Synergistic Plant Metabolomics and Plant Growth-Promoting Microorganisms in Addressing Abiotic Stress

The Enzymes

Fungal and Protozoan Carbonic Anhydrases: Volume 57

Current Topics in Developmental Biology

Kidney Development and Regeneration: Volume 163

Methods in Enzymology

Enzymes of Polyamine Metabolism: Volume 715

Matters of the Image introduces a new framework for thinking about digital images.

Designing Digital Images with Materiality, Energy, and Living Matter

This edited book highlights the experimental approach, using Viruses, Bacteria, lower Eukaryotes and digital organisms. The contributors illustrate approaches revolutionizing our understanding of adaptation, recombination and mutation rates, speciation and the evolutionary transitions from prokaryotic to eukaryotic and from unicellular to multicellular life forms.

Essential Experimental Evolution

Geometric Morphometrics for Biologists: A Primer, Third Edition explores how these geometric methods allow for the study of biological shape by incorporating the geometry of organisms throughout data analyses. Novel content on phylogenetic comparative methods, evolutionary morphology, analyses of disparity, genetics of shape, and simulating shape data is included. This edition delivers step-by-step guidance on how to effectively utilize updated analytical software while also providing guidance on important methodologies that remain relevant to the field to ensure clear and effective instruction to audiences new to this branch of data analysis. It succeeds the second edition as the primary resource for teaching modern geometric methods of shape analysis to students, researchers, and practicing scientists in the field of organismal biology. Users will find it to be an immensely valuable introduction for students and practicing biologists interested in learning applications of multivariate statistics and matrix algebra to organismal biology.

A Primer

Geometric Morphometrics for Biologists

Cryo-EM Methods and Management

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