Almost anything within constitutions, in particular the fundamental and human rights, are is in one or more aspects genuinely affected by the functionalities and effects of digitalization. Established legal understandings and hidden prerequisites on which constitutions are typically built are challenged. The authors analyse different methodological, substantial and comparative legal questions with a particular focus on Artificial Intelligence. With contributions by Prof. Dr. iur. Marion Albers | Prof. Dr. João Bachur | Prof. Dr. Rodrigo Brandão | Dr. Ricardo Campos, LL.M. | Prof. Dr. Edoardo Celeste | Prof. Dr. Victor Oliveira Fernandes | Dr. Giulia Gentile, LL.M. | Dr. Clara Iglesias Keller | Dr. Beatriz Kira | Prof. Dr. Alessandro Mantelero | Prof. Dr. Claudia Lima Marques | Prof. Dr. Gilmar Mendes | Prof. Dr. Laura Schertel Mendes | Prof. Dr. Fabiano Menke | Prof. Dr. Vagelis Papakonstantinou | Prof. Dr. Jane Reis Gonçalves Pereira | Prof. Dr. Alexander Peukert | Prof. Dr. Gabrielle Bezerra Sales Sarlet | Prof. Dr. Ingo Sarlet | Prof. Dr. Indra Spiecker gen. Döhmann, LL.M.