In this issue of Primary Care: Clinics in Office Practice, guest editors Drs. Amanda R. Kost and Karly Pippitt bring their considerable expertise to the topic of Adolescent Medicine. Top experts provide practical approaches to the evaluation, diagnosis, and management of common issues encountered in adolescents in primary care, including vaccination, parenting tips, cultural and generational issues, metabolic screening, LGBTQ health, and more. Contains 12 relevant, practice-oriented topics including IEP: disability, autism, ADHD; harm reduction/MAT; mood disorders; gun violence, accidents, and injuries; relationship safety/IPV; and more. Provides in-depth clinical reviews on adolescent medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.