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Prkachin Y: Wired Together

Wired Together

The Montreal Neurological Institute and the Origins of Neuroscience

How Dinosaurs Reveal the Secrets of Climate Change, Survival, and Humanity's Future

The First Extinction

Mental Health in Historical Perspective

This book explores the marginalisation of thousands of asylum patients who were removed from their home institutions in Scotland during the First World War to make way for soldiers. Examining what life was like for Scotland's mentally ill civilians from 1914-1934, the author explains why and how asylums were taken over by the War Office, and how this created a divide between civilians and soldiers, carved mostly by politicians and the media. The book sheds light on the painstaking process asylum doctors in Scotland went through to find homes for thousands of patients, and how they found ways to protect their health and wellbeing. Providing insights into the patient hierarchy within Scottish asylums, the author argues that soldiers were not the protected class of patient that politicians and the military tried to portray them as. Drawing from the words of Scotland’s asylum patients themselves, this important book highlights the voices of the mentally ill in Scotland during not only a tumultuous period for their nation, but for themselves.Jennifer Farquharson is an independent researcher specialising in early twentieth-century mental healthcare in Scotland, architectural history, and building conservation. She currently works in the heritage sector at Historic Environment Scotland, where she communicates specialist research to general audiences through books, online learning, exhibitions, films, and more. Jennifer was awarded her doctorate in history from Glasgow Caledonian University, in the UK, and is a member of the Society for the Social History of Medicine, the British Society for the History of Science, and an Associate Fellow of the Royal Historic Society.

This book explores the marginalisation of thousands of asylum patients who were removed from their home institutions in Scotland during the First World War to make way for soldiers. Examining what life was like for Scotland's mentally ill civilians from 1914-1934, the author explains why and how asylums were taken over by the War Office, and how this created a divide between civilians and soldiers, carved mostly by politicians and the media. The book sheds light on the painstaking process asylum doctors in Scotland went through to find homes for thousands of patients, and how they found ways to protect their health and wellbeing. Providing insights into the patient hierarchy within Scottish asylums, the author argues that soldiers were not the protected class of patient that politicians and the military tried to portray them as. Drawing from the words of Scotland’s asylum patients themselves, this important book highlights the voices of the mentally ill in Scotland during not only a tumultuous period for their nation, but for themselves.&nbsp;

Life in the Margins

Scotland's Asylums in the First World War

The Rational Use of Cognitive Resources

Principles, Algorithms, and Applications of the Free Energy Principle for Engineers

Fundamentals of Active Inference

Handbook of Clinical Neurology

The evolution of neuroimmunotherapies with the concurrent progress in autoimmune neurology will introduce the book, followed by an update on "non-targeted" therapies highlighting the value of immunosuppressants, plasmapheresis, IVIg or hematopoietic bone marrow transplantation and their mode of action in autoimmune neurology. The new agents in each of these categories, along with biomarkers for therapeutic monitoring and the application of reliable scales in assessing response, will be covered. Chapters will discuss how neuroimmunotherapies work when key molecules and pathways associated with CNS or PNS tissue damage are targeted or inhibited. The volume will describe the approved agents targeting: 1) T-cell intracellular signaling pathways and molecules associated with antigen presentation; 2) B cells, B-cell trophic factors, and autoantibodies; 3) Fc receptor modulation; 4) complement; and 5) cytokines, cell adhesion and transmigration molecules. Didactic schemes and illustrations on how these drugs work in autoimmune neurological diseases will be provided in each chapter. The second part of the book will discuss the latest therapeutics for each major autoimmune neurological disease, aimed to provide a reliable, comprehensive and up-to-date source of information useful for clinical practice and education. Didactic and practical algorithms, a step-by step approach on how best to apply the most suitable therapies for a given state of the disease or proceed to escalation therapies will be provided. Treatment controversies and uncertainties will be authoritatively emphasized by scholars in each field. A chapter addressing potential immunotherapeutic approaches, now on the pipeline or on early trials, as future means of treating some neurodegenerative diseases will be included. Another chapter will cover the new and popular-although controversial -concept of treating autoimmune pain. The book discusses practical therapies with¿traditional immunosuppressants, steroids and IVIg. It describes targeted therapies with monoclonal antibodies or fusion proteins against B cells , T cells, complement, and FcRn, discussing what happens when key factors related to neurological autoimmunity are inhibited. The book provides a "how- to- do" approach for each of the major autoimmune diseases with algorithms and escalation therapies. Dedicated chapters will cover current therapies on encephalitis, NMOSD, Multiple sclerosis , autoimmune neuropathies, myopathies, neuromuscular junction disorders and neuroexcitability disorders like stiff person syndrome. The book is aimed for practitioners and academicians as a reliable and comprehensive source for applying neuroimmunotherapies and understanding their mechanisms.

Wired Together

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