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The Minipig in Biomedical Research,
Second Edition

The Minipig in Biomedical Research, Second Edition

Primarily meant for undergraduate and graduate students wanting to develop their expertise in agricultural sceince and chemistry, this book aims at understanding the basic physical chemistry of soils. In addition, environmental problems such as soil stresses and the interactions between the different environmental components are highlighted. This book serves as a basic tool for students enrolled in agriculture, soil science and environmental science courses.

Primarily meant for undergraduate and graduate students wanting to develop their expertise in agricultural sceince and chemistry, this book aims at understanding the basic physical chemistry of soils. In addition, environmental problems such as soil stresses and the interactions between the different environmental components are highlighted. This book serves as a basic tool for students enrolled in agriculture, soil science and environmental science courses.

Physical Chemistry of Soils

Analytical instrumentation used within regulated analytical laboratories is computerized either via firmware inside the instrument or via a PC workstation with control and application software installed on it. Qualification and validation are typically considered as separate activities with little if any interaction between the two disciplines. The major problem is that you cannot validate the computer system without qualifying the instrument and vice versa. The use of separate approaches impacts the resources needed to establish regulatory compliance. An integrated approach will enable a more efficient and effective use of such resources. This book is based upon a successful two part workshop given by the authors that will address these concerns.

Analytical instrumentation used within regulated analytical laboratories is computerized either via firmware inside the instrument or via a PC workstation with control and application software installed on it. Qualification and validation are typically considered as separate activities with little if any interaction between the two disciplines. The major problem is that you cannot validate the computer system without qualifying the instrument and vice versa. The use of separate approaches impacts the resources needed to establish regulatory compliance. An integrated approach will enable a more efficient and effective use of such resources. This book is based upon a successful two part workshop given by the authors that will address these concerns.

An Integrated Approach to Analytical Instrument Qualification and Computerised System Validation in Analytical Laboratories

Food and Nutritional Toxicology, Second Edition

Clinical Pharmacy and Therapeutics

Approaches and Technologies

Human-Centred AI For Intelligent Healthcare

Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep. Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

Glial Mechanisms in Sleep and Circadian Biology

Pharmacy Education Series

The new edition of a bestseller, this book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. The book places special emphasis on the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, drug metabolism and elimination, and the genetic basis for variations in drug response. The book includes revision and updates of chapters. It also includes new material on pharmacogenomics, cancer chemotherapies, and drug-receptor and drug-enzyme interactions.

The new edition of a bestseller, this book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. The book places special emphasis on the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, drug metabolism and elimination, and the genetic basis for variations in drug response. The book includes revision and updates of chapters. It also includes new material on pharmacogenomics, cancer chemotherapies, and drug-receptor and drug-enzyme interactions.

Understanding Drug Actions and Reactions, Second Edition

Basic Pharmacology

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

Sedimentation Equilibrium Analytical Ultracentrifugation

This book illustrates how the choice of relevant data collection and data analysis techniques is critical for a sound and objective description of the complexity of space-time patterns and processes in ecology and the aquatic sciences. It reviews the concept of complexity in a general ecological context, before introducing a unifying definition of complexity in marine ecology. The book shows that convincing results can arise from very simple, sound, and well-thought-out approaches. The authors underline the risks related to modern techniques of data assimilation that can lead to data inundation, a loss of focus, and ultimately an erroneous scientific approach.

This book illustrates how the choice of relevant data collection and data analysis techniques is critical for a sound and objective description of the complexity of space-time patterns and processes in ecology and the aquatic sciences. It reviews the concept of complexity in a general ecological context, before introducing a unifying definition of complexity in marine ecology. The book shows that convincing results can arise from very simple, sound, and well-thought-out approaches. The authors underline the risks related to modern techniques of data assimilation that can lead to data inundation, a loss of focus, and ultimately an erroneous scientific approach.

A Practical Guide to Avoid Becoming a Mistaken Scientist

Interpreting Ecological Complexity

Meta-analysis Using R

Additive manufacturing enables integrated part manufacture of superalloy parts, especially for the aerospace and power industries. The understanding of non-equilibrium physics, solidification processing routes, metallurgy and computational simulation is essential to enable designers, and practitioners to design and develop superalloy parts.

Additive manufacturing enables integrated part manufacture of superalloy parts, especially for the aerospace and power industries. The understanding of non-equilibrium physics, solidification processing routes, metallurgy and computational simulation is essential to enable designers, and practitioners to design and develop superalloy parts.

Additive Manufacturing of Superalloys

Chemical Receptor Sensory Systems explores chemosenses through the lens of pharmacologic theory, and how chemosensory systems, from the molecular level to the behavior of organisms, must behave given that their operations are functions of receptor pharmacodynamics and pharmacokinetics. Throughout the book, information on concentration-dependence of chemical stimulation and likely relationship to receptor occupancy is strongly emphasized. In cases where a departure from expected pharmacologic behavior is encountered in the chemosenses, the discussion is directed toward probable explanations for the apparent disconnect. This book provides a new resource that on all chemosenses topics within a unifying conceptual framework of the science of pharmacology. It will be useful to a variety of researchers and graduate students in pharmacology, biology and physiology of sensory systems, researchers in sensory psychology, research scientists in food &amp; nutritional scientists, as well as clinical staff.

Chemical Receptor Sensory Systems

The Minipig in Biomedical Research, Second Edition

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