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Targeting Protein-Protein Interactions
for Drug Discovery

Targeting Protein-Protein Interactions for Drug Discovery

Chapter 1: Exploring Protein-Protein Interactions: Concepts, Methods, and Implications 1.1 General concepts of protein-protein interactions 1.2 Functional significance of protein-protein interactions 1.3 Methods for analyzing protein-protein interactions 1.4 Implications of the basic research on protein-protein interactions 1.5 Conclusions and perspectives &nbsp; Chapter 2: Overview of drug discovery targeting PPI systems 2.1 Introduction 2.2 Fundamentals of Protein-Protein Interactions 2.3 Challenges in Targeting PPI Systems 2.4 Approaches in Drug Discovery Targeting PPI Systems 2.5 Case Studies and Success Stories 2.6 Conclusion &nbsp; Chapter 3: Fluorescence Resonance Energy Transfer Technology and its Applications 3.1 Introduction 3.2 Mechanism of FRET 3.3 Applications of FRET 3.4 Advantages and Limitations 3.5 Recent Advances 3.6 Conclusion &nbsp; Chapter 4: Dissect Protein Interactions Using Mass Spectrometry 4.1 Introduction 4.2 Affinity purification coupled with mass spectrometry (AP-MS) 4.3 Proximity labeling 4.4 Cross-linking mass spectrometry (XL-MS) 4.5 Co-fractionation coupled with mass spectrometry (CF-MS) 4.6 Thermal proximity coaggregation (TPCA) 4.7 Limited proteolysis?mass spectrometry (LiP?MS) 4.8 Conclusion and outlook &nbsp; Chapter 5: Detection of protein-protein interactions in situ via proximity ligation assay 5.1 Introduction 5.2 Implementations of proximity ligation assay 5.3 Applications of PLA for detecting protein-protein interactions 5.4 Conclusions and outlooks &nbsp; Chapter 6: The Application of Surface Plasmon Resonance in the Characterization of Protein-Protein Interactions 6.1 Introduction 6.2. Applications of SPR assay in PPI Characterization 6.3. Advantages and Limitations of SPR Application for PPIs 6.4. Future Directions &nbsp; Chapter 7: Computational methods for protein-protein interactions 7.1. Introduction 7.2. Protein-protein docking 7.3. End-to-end structure prediction 7.4. CAPRI experiments 7.5. Challenges and Future directions &nbsp; Chapter 8: Foldamers as Inhibitors of Aberrant Protein-Protein Interactions 8.1 Introduction 8.2 The Evolution of Hamilton?s Oligopyridylamides 8.3 Limitations of a Tedious Synthetic Route 8.4 OPs as Antagonists of Neurodegeneration 8.5 OPs Inhibit HIV Infection 8.6 OPs Targeting Type II Diabetes 8.7 OPs Targeting and Reactivating Mutant Protein in Cancer 8.8 Novel Synthesis of OPs and Alzheimer?s Disease 8.9 2D-FAST 8.10 OQ Foldamers - Structure and Discovery 8.11 Synthesis of OQ Foldamers 8.12 OQs as Modulators of Type II Diabetes-Related aPPIs 8.13 Mechanistic Insights to OQ Manipulation of aPPIs 8.14 Chemical Diversity and Structure Modulate Efficacy of Oqs 8.15 Modulation of Alzheimer?s Disease-Related Aß 8.16 OQs for the Modulation of Synucleinopathies 8.17 Epilogue &nbsp; Chapter 9: Application of Sulfonyl-¿-AApeptides for PPI Drug Discovery 9.1 Introduction to the Structure of Sulfonyl-¿-AA-peptides 9.2 The Applications of Sulfonyl-¿-AA-peptides 9.3 Future Directions/Conclusions &nbsp; Chapter 10: Introduction of the Application of Stapled Peptides in Protein-Protein Interactions Drug Discovery and their Successful Examples 10.1. Introduction 10.2. Stapled Peptides: Structure Features and Benefits 10.3. Successful Applications of Stapled Peptides in Drug Discovery 10.4. Challenges and Limitations 10.5. Future Directions &nbsp; Chapter 11: Cyclic peptides for PPI drug discovery 11.1. a-helix cyclic peptides (stapled peptides) 11.2. ß-hairpin cyclic peptides 11.3. Macrocyclic peptides 11.4. Summary and outlook &nbsp; Chapter 12: Small molecule inhibitors targeting protein-protein interactions in the BCL protein 12.1 Introduction 12.2 Inhibitors of BCL-2 family antiapoptotic proteins 12.3 Inhibitors of ß-catenin/BCL9 12.4 Targeting BCL-6 small molecule inhibitors 12.5. BCL-3 inhibitors 12.6. BCL-10 inhibitors 12.7. Summary &nbsp; Chapter 13: Molecular Glues as Activators for PPI 13.1 Introduction 13.2 Molecular Glues as orthosteric PPI stabilizers/activators 13.3 Methods for Molecular Glue Discovery 13.4 Conclusions and Outlook &nbsp; Chapter 14: Targeting APC?Asef Protein-Protein Interaction for Drug Discovery in Colorectal Cancer Therapy 14.1. Introduction 14.2. Structural insights into APC?Asef interaction 14.3. Current APC?Asef inhibitor 14.4. A More Sensitive FP Method for Identifying Highly Active APC?Asef Inhibitors 14.5. Conclusions and Outlook &nbsp; Chapter 15: Computational methods applied to drug discovery of protein-protein interaction systems 15.1 Introduction 15.2 Computational methods for PPI prediction 15.3 Conclusions and outlook &nbsp;

De Gruyter Textbook

This book gives a concise introduction to the nature, structure, and reactivity of organic compounds. The author introduces complex concepts in an accessible manner. By covering everything from functional groups and spectroscopy to molecular orbital theory and reaction mechanisms, this book gives the reader a true insight into organic chemistry without going into gratuitous amounts of detail.

Organic Reactivity and Reactions

Introductory Organic Chemistry

Production, Storage, and Fuel Cell Technologies

Next-Generation Hydrogen Economy

Spectrophotometry in Food Analysis: Fundamentals, Applications and Methods is an indispensable resource for anyone involved in food analysis. This comprehensive book offers a detailed exploration of analytical techniques and methodologies pivotal to the food industry. Combining a solid overview of fundamental principles with practical case studies, it guides readers through the intricacies of spectroscopic and spectrophotometric analysis. From instrumentation to laboratory techniques, this book covers all essential aspects, making it a must-read for students, researchers, and professionals aiming to enhance their understanding and application of these techniques. The book is systematically divided into nine sections, beginning with a broad overview of spectrophotometry. It progresses to practical applications in food quality, safety, traceability, and characterization, with specific sections dedicated to Raman, Near-Infrared, and FTIR spectroscopy. Each section is enriched with real-world examples, method validations, and troubleshooting tips, ensuring readers gain a robust understanding of the subject. This book is particularly valuable for chemists, food technologists, and laboratory technicians, but also serves as a useful guide for newcomers and interdisciplinary researchers interested in food analysis.

Fundamentals, Applications and Methods

Spectrophotometry in Food Analysis

Wiley Series in Corrosion

Corrosion of Nickel-Based Alloys

Tools and Techniques

Green Engineering and Sustainable Technology

Multifaceted Ligands for Diverse Applications

Terpyridines

Plant-Derived Anti-Cancer Drugs

Sustainable Computing and Optimization

Multi-Criteria Decision Making for Risk Assessment of Emerging Environmental Contaminants

Heterocyclic Compounds as Pharmaceutical Ingredients

Analytical chemistry is a cornerstone of modern chemistry and many of the traditional techniques remain in use, albeit now mostly in automated form. The cognitive and practical skills developed in analytical work has ensured its inclusion in all chemistry programs worldwide. While laboratory work by its nature incorporates the cognitive and psychomotor learning domains, it does not always fully include the affective domain. This can be often attributed to repetition of laboratory activities -- 'we've done this before' -- and so it is useful to have access to a range of more diverse activities to engage and challenge students.This book is a laboratory manual which focuses on chemical analysis, providing teachers with a rich source of novel experiments. It features approximately 60 practical activities which have been extensively beta-tested, and do not require access to specialist equipment. There are worked examples for students and well-developed appendices for instructors and technicians. While not aligned with any specific curriculum, the activities are drawn from content across the nations including AP Chemistry, A-level Chemistry, BTEC National Diploma, Irish Leaving Certificate, Scottish Advanced Higher, International Baccalaureate, Abitur, and Matura. It is suitable for high school, community college, and early undergraduate students, and will be especially useful for those preparing for competitions such as the International Chemistry Olympiad and World Skills as it contains more unusual applications of well-known techniques.

Chemical Analysis For Schools & Colleges: A Lab Manual

Revolutionizing Neurological Disorder

Intranasal Drug Delivery Systems

Properties and Applications of Advanced Materials

Targeting Protein-Protein Interactions for Drug Discovery

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