Über uns

À propos de nous

Nachhaltigkeit

Durabilité

Open Access

Karriere

Carrière

Datenschutz

Protection des données

Impressum

Mentions légales

Zahlung und Lieferung

Paiement et livraison

LEXIA

LEXIA Arbeitsrecht

Was ist LEXIA?

C'est quoi LEXIA ?

LEXIA Familienrecht

Zeitschriften

Revues

recht

Pflegerecht

ZBJV

forumpoenale

ZStrR

Anwaltsrevue

Revue de l'avocat

RSAS

FamPra.ch

ASYL

Life Science Recht

BlAR

Sachbuch

Livres spécialisés

LOKI

Semaphor

Fokusthemen

Focus

Thema

Recht studieren

Arbeitsrecht

Droit du travail

Studium

Études

Familienrecht

Droit de la famille

Sozialversicherungsrecht

Droit des assurances sociales

Strafrecht

Droit pénal

Publikationen

Publications

Literatur

Onlinemodule LEXIA

Modules en ligne LEXIA

Bücher

Livres

Buchreihen

Collections

Datenbanken

recht.ch

Studienliteratur

Littérature pour les études

Services

Dienstleistungen für

Corporate Books

Publishing Lösungen

Aktuelles

Geschäftskunden

Professionnels

Corporate Publishing

Content solutions

Buchhandlungen

Librairies

Veranstaltungen

Événements

Presse

Dozierende

Enseignants

Studierende

Étudiants

Inserierende

Annonceurs

Newsletter

Blog

Autorinnen/Autoren

Auteurs

Unsere Schreibenden

Hilfe

Unsere Autorinnen und Autoren

Liste

Autorenlounge

Espace des auteurs

Bei uns publizieren

Publier chez nous

Autorenstimmen

Témoignages

Verlag

Éditions

Themen

Mehr wissen

Mitarbeitende

Collaborateurs

Geschichte

Histoire

Vision und Mission

Vision et mission

Unser Magazin

Notre magazine

Unternehmenskultur

Culture d'entreprise

Partner

Partenaires

Kontakt

Contact

Shop

Schweizer Recht

Ausländisches Recht

Über unseren Shop

Neuerscheinungen

Nouveautés

Sortiment und Funktionen

Assortiment et recherche

Vorankündigungen

À paraître

Nach Rechtsgebiet

Par domaine juridique

Kommentare

Commentaires

Targeting Protein-Protein Interactions
for Drug Discovery

Targeting Protein-Protein Interactions for Drug Discovery

Chapter 1: Exploring Protein-Protein Interactions: Concepts, Methods, and Implications 1.1 General concepts of protein-protein interactions 1.2 Functional significance of protein-protein interactions 1.3 Methods for analyzing protein-protein interactions 1.4 Implications of the basic research on protein-protein interactions 1.5 Conclusions and perspectives &nbsp; Chapter 2: Overview of drug discovery targeting PPI systems 2.1 Introduction 2.2 Fundamentals of Protein-Protein Interactions 2.3 Challenges in Targeting PPI Systems 2.4 Approaches in Drug Discovery Targeting PPI Systems 2.5 Case Studies and Success Stories 2.6 Conclusion &nbsp; Chapter 3: Fluorescence Resonance Energy Transfer Technology and its Applications 3.1 Introduction 3.2 Mechanism of FRET 3.3 Applications of FRET 3.4 Advantages and Limitations 3.5 Recent Advances 3.6 Conclusion &nbsp; Chapter 4: Dissect Protein Interactions Using Mass Spectrometry 4.1 Introduction 4.2 Affinity purification coupled with mass spectrometry (AP-MS) 4.3 Proximity labeling 4.4 Cross-linking mass spectrometry (XL-MS) 4.5 Co-fractionation coupled with mass spectrometry (CF-MS) 4.6 Thermal proximity coaggregation (TPCA) 4.7 Limited proteolysis?mass spectrometry (LiP?MS) 4.8 Conclusion and outlook &nbsp; Chapter 5: Detection of protein-protein interactions in situ via proximity ligation assay 5.1 Introduction 5.2 Implementations of proximity ligation assay 5.3 Applications of PLA for detecting protein-protein interactions 5.4 Conclusions and outlooks &nbsp; Chapter 6: The Application of Surface Plasmon Resonance in the Characterization of Protein-Protein Interactions 6.1 Introduction 6.2. Applications of SPR assay in PPI Characterization 6.3. Advantages and Limitations of SPR Application for PPIs 6.4. Future Directions &nbsp; Chapter 7: Computational methods for protein-protein interactions 7.1. Introduction 7.2. Protein-protein docking 7.3. End-to-end structure prediction 7.4. CAPRI experiments 7.5. Challenges and Future directions &nbsp; Chapter 8: Foldamers as Inhibitors of Aberrant Protein-Protein Interactions 8.1 Introduction 8.2 The Evolution of Hamilton?s Oligopyridylamides 8.3 Limitations of a Tedious Synthetic Route 8.4 OPs as Antagonists of Neurodegeneration 8.5 OPs Inhibit HIV Infection 8.6 OPs Targeting Type II Diabetes 8.7 OPs Targeting and Reactivating Mutant Protein in Cancer 8.8 Novel Synthesis of OPs and Alzheimer?s Disease 8.9 2D-FAST 8.10 OQ Foldamers - Structure and Discovery 8.11 Synthesis of OQ Foldamers 8.12 OQs as Modulators of Type II Diabetes-Related aPPIs 8.13 Mechanistic Insights to OQ Manipulation of aPPIs 8.14 Chemical Diversity and Structure Modulate Efficacy of Oqs 8.15 Modulation of Alzheimer?s Disease-Related Aß 8.16 OQs for the Modulation of Synucleinopathies 8.17 Epilogue &nbsp; Chapter 9: Application of Sulfonyl-¿-AApeptides for PPI Drug Discovery 9.1 Introduction to the Structure of Sulfonyl-¿-AA-peptides 9.2 The Applications of Sulfonyl-¿-AA-peptides 9.3 Future Directions/Conclusions &nbsp; Chapter 10: Introduction of the Application of Stapled Peptides in Protein-Protein Interactions Drug Discovery and their Successful Examples 10.1. Introduction 10.2. Stapled Peptides: Structure Features and Benefits 10.3. Successful Applications of Stapled Peptides in Drug Discovery 10.4. Challenges and Limitations 10.5. Future Directions &nbsp; Chapter 11: Cyclic peptides for PPI drug discovery 11.1. a-helix cyclic peptides (stapled peptides) 11.2. ß-hairpin cyclic peptides 11.3. Macrocyclic peptides 11.4. Summary and outlook &nbsp; Chapter 12: Small molecule inhibitors targeting protein-protein interactions in the BCL protein 12.1 Introduction 12.2 Inhibitors of BCL-2 family antiapoptotic proteins 12.3 Inhibitors of ß-catenin/BCL9 12.4 Targeting BCL-6 small molecule inhibitors 12.5. BCL-3 inhibitors 12.6. BCL-10 inhibitors 12.7. Summary &nbsp; Chapter 13: Molecular Glues as Activators for PPI 13.1 Introduction 13.2 Molecular Glues as orthosteric PPI stabilizers/activators 13.3 Methods for Molecular Glue Discovery 13.4 Conclusions and Outlook &nbsp; Chapter 14: Targeting APC?Asef Protein-Protein Interaction for Drug Discovery in Colorectal Cancer Therapy 14.1. Introduction 14.2. Structural insights into APC?Asef interaction 14.3. Current APC?Asef inhibitor 14.4. A More Sensitive FP Method for Identifying Highly Active APC?Asef Inhibitors 14.5. Conclusions and Outlook &nbsp; Chapter 15: Computational methods applied to drug discovery of protein-protein interaction systems 15.1 Introduction 15.2 Computational methods for PPI prediction 15.3 Conclusions and outlook &nbsp;

A Guide for Developing, Optimizing, and Validating Procedures

Practical Quantitative Vibrational and Electronic Spectroscopy

Green Protocols

Ionic Liquids in Biomass Processing

Principles of Nutritional Immunology in Health and Disease

Sustainable Computing and Optimization

Multi-Criteria Decision Making for Risk Assessment of Emerging Environmental Contaminants

Studienbücher Chemie

Das ob
 
 der Breite und Tiefe der Behandlung des Gebietes gelobte Lehrbuch erscheint nach 15-jähriger Pause in aktualisierter Neuauflage. Ziel dieses Buches ist die Vermittlung gründlicher Kenntnisse der Organometallchemie der Haupt- und Nebengruppenelemente. Wesentliche Fortschritte werden aufgezeigt, noch bestehende Lücken der Erkenntnis aber nicht verschwiegen. Somit eignet sich das Buch für alle, die an einer gründlichen Einführung in das Gebiet interessiert sind, bietet aber auch Fortgeschrittenen Anreize, in Neuland vorzustoßen. Der Stil der Darstellung ist so gewählt, dass sowohl Einsteiger als auch Eingeweihte profitieren können. Vorausgesetzt wird eigentlich nur eine Grundvorlesung in Anorganischer und Allgemeiner Chemie.
 
 Kennzeichen der aktuellen Entwicklung des Gebietes ist die Intensität der Forschung im Bereich der Hauptgruppenelementorganyle. Dem trägt die 7. Auflage Rechnung, indem
 
 Hauptgruppenelement-Kohlenstoff-Mehrfachbindungen und der Stabilisierung subvalenter Moleküle mittels 
 N
 -heterocyclischer Carbene viel Raum zugestanden wird. Ein Alleinstellungsmerkmal des Buches, die Behandlung der Organometallchemie der Hauptgruppen- 
 und 
 der Nebengruppenelemente gestattet dabei einen ganzheitlichen
 
 Ansatz.&nbsp;
 
 Die systematische Chemie – Beschreibung von Synthese und Eigenschaften von Molekülen mit Metall-Kohlenstoff-Bindungen, „Chemie für Chemiker“, – wird komplementiert durch deren Anwendungen auf die Organometallchemie 
 in vivo
 , die metallorganische Komplexkatalyse und daraus abgeleitete Syntheseverfahren. Letztere werden nur exemplarisch behandelt, da hierfür zahlreiche spezialisierte Monographien existieren. Ähnliches gilt für Struktur und Eigenschaften von Organometallclustern, deren Systematik hier mittels inzwischen schon klassischer Elektronenabzählregeln behandelt wird, die aber zunehmend Gegenstand quantenchemischer Rechnungen geworden sind, deren explizite Behandlung den Rahmen dieses Buches sprengen würde.
 
 Unseres Erachtens wichtige Erweiterungen bietet die 7. Auflage in einer ausführlichen Behandlung der Organometallchemie des Kohlendioxids und mit den neuen Kapiteln 
 19 Oberflächenorganometallchemie
 und 
 20 Organometallelektrochemie: Cyclovoltammetrie
 . Während Kapitel 19 eine Brücke zwischen homogener und heterogener Organometallkatalyse schlägt, zeigt Kapitel 20 auf, wie durch den Transfer eines Elektrons metallorganische Spezies mit neuen Eigenschaften erzeugt und studiert werden können.
 Die AutorenProf. Dr. Christoph Elschenbroich
 &nbsp;1975–2004 in Forschung und Lehre tätig an der Philipps-Universität Marburg, Gastprofessuren in Zürich, Brookhaven NY und Paris. Arbeitsgebiete: Synthetische und physikalische Organometallchemie der Aromaten-Übergangsmetall-Komplexe. Literaturpreis des Fonds der Chemischen Industrie (1988). Nach der Emeritierung (2004) auch kommunalpolitisch tätig (Kulturpolitik und Bürgerbeteiligung), Kulturplakette 2019.&nbsp;
 Prof. Dr. Marc Walter
 &nbsp;Promotion (2005) an der TU Kaiserslautern und UC Berkeley. Postdoktorat (2006–2010) an der UNC Chapel Hill. Seit 2017 Professor für Anorganische Chemie an der TU Braunschweig. Arbeitsgebiete: Synthese und Reaktivität von Cyclopentadienyl- und Pentadienyl-Komplexen, Organo-f-Element-Chemie. 2014&nbsp;DFG Heinz Maier-Leibnitz-Preis und GDCh Wöhler-BASF-Nachwuchspreis.&nbsp; &nbsp;&nbsp; &nbsp;

Organometallchemie

This book is designed to explain how to use Valence Bond theory to think concisely and rigorously and how to use VB computations. It is intended for chemists who are not necessarily experts on theory, but have some background in quantum chemistry. It familiarizes the reader with the various VB-based computational tools and methods available today and their use for a given chemical problem. It provides samples of inputs/outputs and instructs the reader on how to interpret the results. Applications discussed in the book include bonding problems, organic reactions, inorganic/organometallic reactions, and bioinorganic/biochemical reactions.

Insights into Chemical Bonding, Reactivity, and Excited States

A Chemist's Guide to Valence Bond Theory

RMS - Royal Microscopical Society

Comprehensive reference exploring microscopy techniques to support the study of living systems with a unique multiscale focus Live Biological Imaging Across Scales presents an overview of the technologies and experimental strategies available for live imaging across scales. Each chapter highlights a different technique, working upwards from small to large scale. Readers will find critical evaluation of these techniques and perspectives on future developments in this evolving field, enabling them to effectively identify techniques that may benefit their research activities. Written by a team of leading experts and part of the Wiley-Royal Microscopical Society series, Live Biological Imaging Across Scales includes information on: <ul> <li>Single cells, covering single molecule tracking/FRET, actin, septins, vesicles, and phagosomes</li> <li>Multiple cells, covering collective migration, endothelial monolayers, wound healing, monocyte transmigration, cancer spheroids/tumor models, and organoids</li> <li>Organisms, covering Dictyostelium, C. elegans, Drosophila, and mouse-tumors</li> <li>Imaging of whole cells individually and collectively in both 2D and 3D platforms</li> </ul> Live Biological Imaging Across Scales is an essential reference for microscopists and experimental biologists, particularly those interested and/or working in the expanding field of live imaging in biology, as well as those working in the commercial microscopy industry supply and development.

Live Biological Imaging Across Scales

Catalytic Nanomaterials for Energy, Environmental and Chemical Applications

Layered Double Hydroxides and Oxides

Principles of Polymerization

Wiley Series on Mass Spectrometry

This book encompasses topics from the fundamentals of disease related protein misfolding and mass spectrometry, to current research highlights in these areas. It is aimed to provide an overview of this rapidly developing field in order to present a good mixture of information that will encourage people to participate in, and further the use of mass spectrometry in studying protein misfolding with biologically relevant applications. Using examples from the current literature, the book focuses on details relating to understanding the fundamentals of disease related protein misfolding, conducting and optimising the mass spectrometry experiment, and also future prospects of methodologies within this rapidly evolving and topical research area.

Using current examples and high-quality illustrations, this book covers topics including how to conduct and optimize experiments; the structural and atomic level information afforded by mass spectrometry in disease related protein systems, and incorporates future research prospects.

Insights from Mass Spectrometry

Protein Misfolding, Aggregation and Disease

Theoretical and Computational Chemistry

Methods and Applications

Introduction to Computational Chemistry

The definitive book on Intervention Mapping, with practical steps for students and practitioners in the health promotion field Planning Health Promotion Programs is a highly practical guide to the planning process, focusing on a framework called Intervention Mapping. This book presents a series of steps, tasks, and processes that help you develop effective health promotion and education programs. You'll learn a range of approaches and models for predicting health behavior and environmental changes, and you'll get clear explanations of how to integrate theoretical constructs into effective promotion and education solutions. This new Fifth Edition brings the latest theories and research to bear on the Intervention Mapping process. You'll also gain access to a companion website with lecture slides, additional case studies, and a test bank. As the go-to resource in the field of health promotion planning, this remains indispensable for students and practitioners. <ul> <li>Merge multiple theories into a single health education solution</li> <li>Learn the methods and processes of intervention planning</li> <li>Gain a practical understanding of multiple planning approaches</li> <li>Get up to date on the latest theories, trends, and developments in the field</li> </ul> This realistic planning handbook offers a system for program development, recognizing that one size cannot fit all. Planning Health Promotion Programs is the essential guide to the process, equipping you with the knowledge and skills to develop effective solutions.

Planning Health Promotion Programs: An Interventio n Mapping Approach, 5th Edition

Targeting Protein-Protein Interactions for Drug Discovery

Autres titres sur ce thème