What do two Japanese detectives, a naked man on a city street, and a roundworm from Botswana all have in common? In this first volume of Manhole, Ken Mizoguchi and Nao Inoue are a pair of investigators asking themselves this very question as they string together clues to solve a string of bloody and mysterious murders. But as the pieces come together, they begin to uncover the threat of a deadly biological agent which poses a threat of epidemic proportions.