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Cotton Simon: Every Molecule Matters

Every Molecule Matters

Chromatographic Science Series

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Analytical Aspects of Bioequivalence

Chemical Receptor Sensory Systems explores chemosenses through the lens of pharmacologic theory, and how chemosensory systems, from the molecular level to the behavior of organisms, must behave given that their operations are functions of receptor pharmacodynamics and pharmacokinetics. Throughout the book, information on concentration-dependence of chemical stimulation and likely relationship to receptor occupancy is strongly emphasized. In cases where a departure from expected pharmacologic behavior is encountered in the chemosenses, the discussion is directed toward probable explanations for the apparent disconnect. This book provides a new resource that on all chemosenses topics within a unifying conceptual framework of the science of pharmacology. It will be useful to a variety of researchers and graduate students in pharmacology, biology and physiology of sensory systems, researchers in sensory psychology, research scientists in food &amp; nutritional scientists, as well as clinical staff.

Chemical Receptor Sensory Systems

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

Structural Biology of Amyloid Fibrils

Plant Biology, sustainability and climate change

Radiation Spectrum and Plant Metabolism: Interaction from the Sub-cellular to Ecosystem Level offers a clear illustration of the interaction between radiation spectrums and the dynamics of biological systems in plants. Explaining the light-Phyllosphere relationship, this volume describes metabolite chemistry, thus reflecting the developmental and functional fitness of the plant. As climate change has resulted in a natural variation in the cosmic radiation spectrum, a knowledge gap has emerged about the changing radiation spectrum and its impacts on plant metabolism. This book addresses the subject in-depth, providing insights into the functional role of photoreceptors, pigments, and various metabolites in coping with this alteration. It will be a valuable reference for photo biologists, biophysicists, and biochemists for deciphering the impacts of radiation spectrum on plant metabolism. Researchers working in the field of metabolite chemistry and metabolomics will also find it useful to comprehend the physical laws governing the interaction of radiation spectrum with biological system.

Interaction of Radiation Spectrum with Sub Cellular Ecosystem Level

Radiation Spectrum and Plant Metabolism

Synthesis

How Chemical Dyes Changed the West's Relationship with Food

A Rainbow Palate

Functional Foods and Nutraceuticals

Seaweeds are a rich source of number of metabolites such as polyphenols, polysaccharides, fatty acids, proteins, peptides, which can be used as functional ingredients in many industrial applications such as functional food, nutraceuticals, pharmaceuticals and cosmeceuticals. While chromatographic and spectroscopic techniques have made bioactives analysis easier than before, their successful analysis depends on extraction techniques used. The book covers various emerging technologies for the extraction and characterization of bioactive compounds from seaweeds. The book provides in-depth information about the technique, its benefits and disadvantages, and potential industrial applications.

Seaweeds are a rich source of number of metabolites such as polyphenols, polysaccharides, fatty acids, proteins, peptides, which can be used as functional ingredients in many industrial applications such as functional food, nutraceuticals, pharmaceuticals and cosmeceuticals. While chromatographic and spectroscopic techniques have made bioactives analysis easier than before, their successful analysis depends on extraction techniques used. The book covers various emerging technologies for the extraction and characterization of bioactive compounds from seaweeds. The book provides in-depth information about the technique, its benefits and disadvantages, and potential industrial applications.

Extraction and Characterization Techniques

Seaweed Bioactives

Food and Nutritional Toxicology, Second Edition

This book emphasizes how new generation materials discovered recently (like graphene and topological insulators) can be understood using simple Quantum Transport Theory. The book could also be used as a text in Advanced Solid State/Condensed Matter Courses in Physics or Chemistry and in branches of Engineering.

This book emphasizes how new generation materials discovered recently (like graphene and topological insulators) can be understood using simple Quantum Transport Theory. The book could also be used as a text in Advanced Solid State/Condensed Matter Courses in Physics or Chemistry and in branches of Engineering.

Quantum Transport in Dirac Materials

Clinical Pharmacy and Therapeutics

A completely revised edition of a comprehensive and popular introduction to the fast moving area of forensic genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field. Key Features: Greater inÂ-depth coverage of sequencing technology; updates and expansion of collection methods, characterization of body fluids using RNA, transfer of DNA; significant updates next generation sequencing, rapidly mutating STRs, whole mtDNA sequencing, X chromosome markers. New chapter on phenotype prediction and prediction of biological ancestry Self-assessment questions to aid student understanding throughout the text. Companion website

An Introduction to Forensic Genetics

Chain Reaction

A Computational Approach

Modeling Structure-Function Relations in Ion Channels

Every Molecule Matters

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