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Cotton Simon: Every Molecule Matters

Every Molecule Matters

AAPS Advances in the Pharmaceutical Sciences Series

A Roadmap

Pediatric Formulations

Principles of Nutritional Immunology in Health and Disease

Synthesis to Applications

Lanthanide Complexes

Practical Analytical Testing and Processing Methods for Cannabis and Hemp-Based Products

A completely revised edition of a comprehensive and popular introduction to the fast moving area of forensic genetics. The text begins with key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field. Illustrated in full colour throughout, this accessible textbook includes numerous references to relevant casework. With information on the full process of DNA evidence from collection at the scene of a crime to presentation in a legal context this book provides a complete overview of the field. Key Features: Greater inÂ-depth coverage of sequencing technology; updates and expansion of collection methods, characterization of body fluids using RNA, transfer of DNA; significant updates next generation sequencing, rapidly mutating STRs, whole mtDNA sequencing, X chromosome markers. New chapter on phenotype prediction and prediction of biological ancestry Self-assessment questions to aid student understanding throughout the text. Companion website

An Introduction to Forensic Genetics

Methods in Enzymology

RNA Enzymology and Technology: Volume 725

Synthesis

Matter and Value in the Scientific Revolution

Gems and the New Science

This book will not only deal with the analysis of nutraceuticals, but will also focus on the extraction and purification of the analytes using newer tools/instruments. It will also help the analyst during the actual estimation of these compounds from different matrices.

This book will not only deal with the analysis of nutraceuticals, but will also focus on the extraction and purification of the analytes using newer tools/instruments. It will also help the analyst during the actual estimation of these compounds from different matrices.

Practical Guide to LC Analysis of Nutraceuticals

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

Sedimentation Equilibrium Analytical Ultracentrifugation

Prevention and Treatment

Side Effects of Cancer Therapy

Artificial intelligence (AI) is extensively used in scientific research nowadays and has reshaped the practice in academia, industry, business, cybersecurity, etc. However, this revolution has not touched organic chemistry, the field appreciably frozen in its methods, until the last few years.This book is the first to introduce the contemporary AI-driven computerization of organic laboratory. It is designed to be a basic practical guide that is organic chemist-friendly, dispensing with abstract treatments of the mathematical theory of machine learning, while strongly focusing on the recently developed mélange of AI-carrying software that simplify and accelerate the planning of organic synthesis and structure elucidation. It will explain to organic, bioorganic, and natural product chemists what AI and its applicative approaches are, while techniques of these AI approaches will be schematically described. Perspectives of using AI in instrumental separation of organic compounds will also be discussed.For researchers from organic laboratories worldwide, this book is certainly the timely key to the toolbox of various chemistry-oriented AI software that is beginning to revolutionize the age-old practice of experimental organic research.

Reshaping Experimental Organic Research With Smart In Silico Tools: Invitation To Artificial Intelligence-equipped Organic Lab

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

Structural Biology of Amyloid Fibrils

Every Molecule Matters

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