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International Review of Cell and Molecular Biology

Epigenetic Regulation of Cancer - Part
A: Volume 380

Epigenetic Regulation of Cancer - Part A: Volume 380

This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.

Chemokine Receptors in Health and Disease: Volume 388

Mitochondria and Bacterial Pathogens, Part B, Volume 375 discusses different pathogenic mechanisms that converge on the ability of bacteria to control the mitochondrial compartment of host cells. Chapters in this new release include Interaction between host cell mitochondria and Coxiella Burnetii, Control of mitochondrial functions by Pseudomonas aeruginosa in cystic fibrosis, Mitochondrial and bacterial ATP synthase: Structural similarities and divergences to exploit in the battle against M. tuberculosis, Role of mitochondria in the enteropathogenic Escherichia coli disease, Mitochondria dynamics and antibiotic resistance, and more.

Mitochondria and Bacterial Pathogens - Part B: Volume 377

For over half a century, DNA has dominated science and the popular imagination as the "secret of life". But over the last several decades, a quiet revolution has taken place. In a series of breathtaking discoveries, the biochemist Thomas R. Cech and a diverse cast of brilliant scientists have revealed that RNA-long overlooked as the passive servant of DNA-sits at the centre of biology's greatest mysteries. In The Catalyst, Cech brings together years of research to demonstrate that RNA is the true key to understanding life on Earth, from its origins to our future in the twenty-first century.
A gripping journey of discovery, The Catalyst moves from the early experiments that first hinted at RNA's spectacular powers, to Cech's own paradigm-shifting finding that it can catalyse cellular reactions, to the cutting-edge biotechnologies poised to reshape our health. We learn how RNA-once thought merely to transmit DNA's genetic instructions to the cell's protein-making machinery-may have jump-started life itself, and how, at the same time, it can cut our individual lives short through viral diseases and cancer. We see how RNA is implicated in the ageing process and explore the darker depths of the supposed fountain of youth, telomerase. And we catch a thrilling glimpse into how RNA-powered therapies-from CRISPR, the revolutionary tool that uses RNA to rewrite the code of life, to the groundbreaking mRNA vaccines that have saved millions during the pandemic, and more-may enable us to improve and even extend life beyond nature's current limits.
The Catalyst is a must-read guide to the present and future of biology and medicine.

RNA and the Quest to Unlock Life's Deepest Secrets

The Catalyst

»Wenn Sie nur ein Buch über Biologie lesen könnten, lesen Sie Paul Nurse.« DIE ZEIT
 Was ist Leben? Und was bedeutet die Antwort auf diese Frage für die Herausforderungen, denen sich die Menschheit heute gegenübersieht - Klimawandel, Pandemien und Artensterben? Paul Nurse erhielt den Nobelpreis dafür, gezeigt zu haben, wie lebende Zellen funktionieren. In seinem so klar wie elegant verfassten Buch synthetisiert er auf wenigen Seiten sämtliches Wissen darüber, was es heißt, am Leben zu sein. Schritt für Schritt erläutert Nurse die fünf revolutionären Ideen, die der Biologie zugrunde liegen - die Zelle, das Gen, Evolution durch natürliche Selektion, das Leben als Chemie und das Leben als Information.
 »Das Buch ist so inspiriert und kenntnisreich geschrieben - und die fünf Abschnitte so angefüllt mit überraschenden Erkenntnissen -, dass ich es nicht aus der Hand legen konnte.« Siddhartha Mukherjee

»Wenn Sie nur ein Buch über Biologie lesen könnten, lesen Sie Paul Nurse.« DIE ZEITWas ist Leben? Und was bedeutet die Antwort auf diese Frage für die Herausforderungen, denen sich die Menschheit heute gegenübersieht – Klimawandel, Pandemien und Artensterben? Paul Nurse erhielt den Nobelpreis dafür, gezeigt zu haben, wie lebende Zellen funktionieren. In seinem so klar wie elegant verfassten Buch synthetisiert er auf wenigen Seiten sämtliches Wissen darüber, was es heißt, am Leben zu sein. Schritt für Schritt erläutert Nurse die fünf revolutionären Ideen, die der Biologie zugrunde liegen – die Zelle, das Gen, Evolution durch natürliche Selektion, das Leben als Chemie und das Leben als Information.»Das Buch ist so inspiriert und kenntnisreich geschrieben – und die fünf Abschnitte so angefüllt mit überraschenden Erkenntnissen –, dass ich es nicht aus der Hand legen konnte.« Siddhartha Mukherjee

Die fünf Antworten der Biologie

Was ist Leben?

Forensic Biology, Third Edition provides students with a general understanding of forensic biology, particularly in forensic serology and forensic DNA analysis, and addresses rapid advancements in the field over the past few years.

Forensic Biology, Third Edition provides students with a general understanding of forensic biology, particularly in forensic serology and forensic DNA analysis, and addresses rapid advancements in the field over the past few years.

Forensic Biology

Wolpert's Principles of Development, the latest edition of the prize-winning textbook, opens up the fascinating field of developmental biology to undergraduates studying biology, medicine, and veterinary science. By focusing on the underlying processes shared by diverse organisms, the textbook lays the foundation for a deep understanding. 

Key features 
- An emphasis throughout on the underlying principles - which underpin the commonalities between different organisms and their development - enables students to get a clear sense of the 'big picture' of the subject. 
- Custom-drawn artwork and integrated animations and videos help to make the visualisation of processes and mechanisms in this challenging subject as straightforward as possible. 
- Medical Boxes explore key developmental diseases and explain how developmental biology furthers our understanding human health and disease. Further experimental detail, including Experimental Boxes, from both classic and current research, demonstrates 'how we know what we know'. 
- Also available as an e-book enhanced with learning objectives, self-assessment interactive quizzes and multi-media content to offer a fully immersive experience and extra learning support. 

New to this edition 
- Chapter 7, a new chapter on Embryonic stem cells, embryo models, and regenerative medicine, to ensure the book's coverage stays up to date with this very active area of developmental biology research. 
- Chapters 3 and 4 on vertebrate development have been restructured and updated, especially in relation to mouse development, to ensure major concepts and principles are explained with recent supporting experimental evidence. 
- Chapter 10 on the nervous system has been completely revised and updated, with more emphasis on neural tube patterning. 
- Chapter 14, which covers nematodes and sea urchins, now appears online as part of the ebook. 
- There are more examples of the use of CRISPR to address problems like sickle cell disease (Ch6), and evolution of limbs from fins (Ch13). 
- Examples of single-cell RNA sequencing can be found throughout the book (Ch3, Ch6, Ch7, Ch10, Ch11, Ch12). 

- Smaller revisions, updates, and new figures have been included throughout. Digital formats and resources 
The seventh edition is available for students and institutions to purchase in a variety of formats: the e-book and Science Trove offer a mobile experience and convenient access along with interactive self-test questions, videos, flashcards, supplementary materials, functionality tools, navigation features and links that offer extra learning support. 

For more information about e-books, please visit www.oxfordtextbooks.co.uk/ebooks

Wolpert's Principles of Development, the latest edition of the prize-winning textbook, opens up the fascinating field of developmental biology to undergraduates studying biology, medicine and veterinary science. By focusing on the underlying developmental processes which are shared by diverse organisms, the textbook lays the foundation for deep understanding.

Wolpert's Principles of Development

A profound, human history of biology's most vital idea.From the bestselling, Pulitzer Prize-winning author of The Emperor of All Maladies comes a sweeping exploration of the cell - the building block of all living things. In The Song of the Cell, Siddhartha Mukherjee traces how centuries of scientific endeavour and discovery, from early microscopes to stem-cell therapy, have transformed medicine and our understanding of what it means to be alive.Woven through this history are stories of patients, scientists, and personal insight. As Mukherjee shows, the cell's music is the song of life itself - complex, adaptive, and full of wonder. Essential reading for fans of popular science and the history of medicine.Longlisted for the Baillie Gifford Prize 2023A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR'Will leave you in awe' Guardian'Profound... as big a topic as life itself' The Times

**Longlisted for the Baillie Gifford Prize 2023** A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR From the dawn of life itself, every being that has ever lived owes its existence to the cell. 'Will leave you in awe' Guardian The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether. Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better. 'Profound...As big a topic as life itself' The Times 'Medical magic' Daily Telegraph 'Vast...important...optimistic' Mail on Sunday

The Story of Life

The Song of the Cell

Algae have played a crucial role in shaping our planet's atmosphere, as they transform CO2 into the oxygen we breathe. They contribute to building a sustainable future by aiding in the fight against climate change, providing new energy sources and essential resources for nutrition. NATHANAEL PRINGSHEIM (1823-1894), a pioneer of modern botany and a contemporary of Charles Darwin, revolutionized the understanding of biology. In his research on algae, Pringsheim revealed that sexuality was a fundamental principle even in organisms previously classified as "lower" life forms.This book offers readers:<ul><li>exciting insights into the development of modern biology illustrated through Pringsheim's fascinating life and scientific achievements,</li><li>the first-ever account of the Pringsheim family, persecuted in the Third Reich, and their contributions to the natural sciences,</li><li>an enthralling narrative of the challenging journey to establish the first German marine biology research station on the island of Helgoland,</li><li>an appealing showcase of large-scale artistic interpretations of microscopic worlds, created by Pringsheim, also a master of scientific illustration</li><li>and last but not least, new perspectives on algae research, which is more relevant today than ever before.</li>
</ul>https://doi.org/10.47261/1584

Unmasking Algae's Innocence, the Nathanael Pringsheim Revolution

Archetypes of Sex

Independently published

What if the secret to better energy, sharper thinking, stronger performance, and healthier aging lies inside nearly every cell in your body?Mitochondria Explained takes you on a fascinating journey into the microscopic powerhouses that keep your body functioning. Far more than simple energy producers, mitochondria influence metabolism, brain health, physical endurance, immune function, cellular repair, and the aging process.Written in clear, accessible language, this book explains how mitochondria produce energy, why their performance can decline, and how everyday factors such as nutrition, exercise, sleep, stress, environmental exposure, and lifestyle habits can affect their health.Inside, you will discover: How mitochondria convert food and oxygen into usable cellular energyWhy mitochondrial health matters for fatigue, metabolism, focus, and physical performanceHow oxidative stress and inflammation can damage your cellsThe connection between mitochondria, chronic disease, and agingHow exercise, sleep, nutrition, and recovery support mitochondrial functionPractical, evidence-informed strategies for protecting your cellular energy systemsWhether you are interested in improving your energy, optimizing performance, supporting long-term health, or simply understanding how your body works, Mitochondria Explained provides a practical and engaging introduction to one of the most important systems in human biology.Discover how supporting the smallest structures in your cells may help you build a stronger, more energetic, and more resilient life.

How Your Cellular Powerhouses Shape Energy, Health, Performance, and Longevity

Mitochondria Explained

Durch die Genomeditierung mit der Genschere CRISPR/Cas und den Einsatz künstlicher Intelligenz bei der Analyse genetischer Daten erleben wir eine neue Dimension der Gentechnik. Wir sind die Generation mit der Genschere. Die Ergebnisse reichen von blutdrucksenkenden Tomaten und Gentherapien gegen Krebs über die Schaffung bakterieller Chassis als molekulare Werkstätten bis hin zur Wiedergeburt des ausgestorbenen Schattenwolfs und der ersten (Er)Zeugung von Designer-Babys.

Wie weit dürfen wir gehen? Gehört unsere Zukunft der Genomarchitektur? Brauchen wir Gentechnik, um den Herausforderungen des Klimawandels zu begegnen? Rettet uns künstliche Intelligenz vor einer genetischen Datenflut – oder macht sie Gesundheit und Therapie zu einer unverständlichen Blackbox?
Neue genomische Techniken ermöglichen präzise Eingriffe in das Erbgut – ganz ohne erkennbare Spuren. Sie basieren auf unserem wachsenden Verständnis von Genen, deren Bausteinen, epigenetischen Faktoren und Funktionen. Besonders in der Pflanzenzüchtung finden sie zunehmend Anwendung.

Dieses Buch vermittelt anschaulich und verständlich die Entwicklung der modernen Gentechnologie. Es lädt dazu ein, ethische, gesellschaftliche und rechtliche Fragen zu diskutieren.

Neu in dieser Auflage: Das Kapitel Gene und Gesetze beleuchtet die rechtlichen Rahmenbedingungen der Gentechnik in Züchtung und Medizin. Das Thema künstliche Intelligenz wurde erweitert, andere Kapitel wurden aktualisiert.

Durch die Genomeditierung mit der Genschere CRISPR/Cas und den Einsatz künstlicher Intelligenz bei der Analyse genetischer Daten erleben wir eine neue Dimension der Gentechnik. Wir sind die Generation mit der Genschere. Die Ergebnisse reichen von blutdrucksenkenden Tomaten und Gentherapien gegen Krebs über die Schaffung bakterieller Chassis als molekulare Werkstätten bis hin zur Wiedergeburt des ausgestorbenen Schattenwolfs und der ersten (Er)Zeugung von Designer-Babys.
 Wie weit dürfen wir gehen? Gehört unsere Zukunft der Genomarchitektur? Brauchen wir Gentechnik, um den Herausforderungen des Klimawandels zu begegnen? Rettet uns künstliche Intelligenz vor einer genetischen Datenflut – oder macht sie Gesundheit und Therapie zu einer unverständlichen Blackbox?
 
 Neue genomische Techniken ermöglichen präzise Eingriffe in das Erbgut – ganz ohne erkennbare Spuren. Sie basieren auf unserem wachsenden Verständnis von Genen, deren Bausteinen, epigenetischen Faktoren und Funktionen. Besonders in der Pflanzenzüchtung finden sie zunehmend Anwendung.
 Dieses Buch vermittelt anschaulich und verständlich die Entwicklung der modernen Gentechnologie. Es lädt dazu ein, ethische, gesellschaftliche und rechtliche Fragen zu diskutieren.Neu in dieser Auflage
 : Das Kapitel Gene und Gesetze beleuchtet die rechtlichen Rahmenbedingungen der Gentechnik in Züchtung und Medizin. Das Thema künstliche Intelligenz wurde erweitert, andere Kapitel wurden aktualisiert.

Wie CRISPR und KI unser Leben verändern

Gentechnik im Wandel

Bacteria are the most ubiquitous life-forms on Earth, and are studied extensively to gain insight into their function and understand how they interact with their environment. In recent years, bacterial biophysics has added a new dimension to this research by using the tools of physics to investigate the quantitative principles that underpin these cellular systems. This book provides a modern and cohesive introduction to bacterial biophysics, with a focus on biofilms, slimes and capsules. In the first of three sections, key techniques and models from the physical sciences that can be applied to bacterial problems are presented. Section 2 then provides a bacterial microbiology primer for physical scientists and an examination of single-cell phenomena. The final section explores interacting bacteria and biofilms from a physical perspective. Ideal for physics graduates interested in this important field, this book is also relevant for researchers in physical chemistry, bioengineering, mathematics and microbiology.

From Cells to Biofilms

The Physics of Bacteria

Biotechnology: The Technological Applications of Genetics and Genomics, Third Edition, approaches modern biotechnology from a molecular basis, discussing how the fields of genetics, molecular biology, microbiology, and biochemistry are merging their respective discoveries into the expanding applied field of biotechnology. Each chapter starts with basic concepts that develop into more specific and detailed applications, providing readers with a good image of possibilities and current limitations in the field and future research directions. This new edition has been fully revised and updated to include research advances, and has new chapters on artificial intelligence, genome editing, precision and personalized medicine, and more. This book is an invaluable resource to anyone interested in understanding what molecular biotechnology is as a scientific discipline, how research in this area is conducted, and how this technology may impact the future.

The Technological Applications of Genetics and Genomics

Biotechnology

Lippincott Illustrated Reviews Series

Selected as a Doody's Core Title for three years running! &nbsp; A bestselling title in this highly regarded review series, Lippincott® Illustrated Reviews: Biochemistry is the go-to resource for both faculty and students for mastering the essentials of biochemistry. The fully revised 9th Edition helps students quickly review, assimilate, and integrate large amounts of critical and complex information, with unparalleled illustrations that bring concepts to life. An intuitive outline organization, chapter summaries, and review questions that link basic science to real-life clinical situations work together to clarify challenging information and strengthen retention and understanding, while an emphasis on clinical application, updated review tools, and accompanying digital resources prepare students for success on course and board exams and beyond. Every aspect of Lippincott® Illustrated Reviews: Biochemistry, 9th Edition, has been brought fully up to date, including: <ul><li>Student-friendly features such as chapter overviews, summaries, board-style questions and answers, Clinical Application boxes, case studies with questions and answers, online animations, and more. </li><li>Vibrant illustrations and detailed tables that clarify complex biochemical concepts. </li><li>Study questions and answers for each chapter that test students’ retention and strengthen their test-taking confidence. </li><li>Integrative case studies with review questions familiarize students with commonly encountered clinical scenarios and alert them to potential widespread implications of presenting issues. </li><li>Cross-references&nbsp;to other Lippincott® Illustrated Reviews titles that help students grasp how biochemical concepts relate to other basic sciences. </li></ul>

Lippincott® Illustrated Reviews: Biochemistry

A leading bacteria scientist combines unique scientific and artistic&nbsp;techniques, along with accessible text to reveal the microbial world within and around us. Beautiful Bacteria merges stunning imagery with a new way of looking at something we interact with every day. Each chapter introduces the different types of bacteria, illustrated with singularly beautiful images of these minute life forms and an approachable text that explains where bacteria is located and what it does. Much as New York Times bestseller I Contain Multitudes did, Beautiful Bacteria brings the invisible world that has shaped our species to life. While we know microbes in our world are relevant, the focus of this book is what the invisible, microbial world looks like, where it comes from, and where new discoveries and biotechnology are taking us. Looking at the microbial world reveals countless questions about life and connects with the personal realm of bacteria in our daily lives. From the dazzling patterns of Proteus mirabilis to the shimmering fractals of E. coli and more, each chapter touches upon the little-seen microscopic universe and the impact it has on our macroscopic society, and sheds light on how we coexist in an increasingly biotechnological world.

A leading bacteria scientist combines unique photographic techniques and accessible text to reveal the microbial world within and around us.

Encounters in the Microuniverse

Beautiful Bacteria

Epigenetic Regulation of Cancer - Part A: Volume 380

Weitere Titel der Reihe: International Review of Cell and Molecular Biology

Weitere Titel zum Thema