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Interdisciplinary Cancer Research

Cancer Metastasis, Management and
Complications: An Interdisciplinary App

Cancer Metastasis, Management and Complications: An Interdisciplinary Approach

Challenges in Solid Tumors and Other Cancers: An Interdisciplinary Approach

Artificial Intelligence and Bioinformatics in Cancer: An Interdisciplinary Approach

Cancers in Different Conditions, Cancer Research Methods and Diagnosis: An Interdisciplinary Approach

Gynecological Cancers: An Interdisciplinary Approach

The “Urogenital Cancers: An Interdisciplinary Approach” is the sixteenth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive volume on diagnosis and treatment of urogenital cancers. The volume starts with a general chapter on interdisciplinary approach in genitourinary cancers. After discussion on upper tract urothelial carcinoma, bladder cancer, and renal cell carcinoma, immunobiology of testicular cancer is explained. The subsequent chapters are focused on prostate cancer. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for urologists, nephrologists, and oncologists who wish to have an update on diagnosis and treatment of urogenital cancers.

Urogenital Cancers: An Interdisciplinary Approach

The “Cutaneous Cancers: An Interdisciplinary Approach” is the fifteenth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive volume on diagnosis and treatment of cutaneous cancers. The volume starts with a general chapter on interdisciplinary approach in cutaneous cancers. Epigenomic markers in dermato-oncology is discussed in the next chapter. Macrophage-mediated cancer immunology and the role of inflammatory cells in skin cancer genesis are explained in subsequent chapters. Pathophysiology and treatment of specific cutaneous cancers, including melanoma, are discussed in the following chapters. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for dermatologists and oncologists who wish to have an update on diagnosis and treatment of cutaneous cancers.

Cutaneous Cancers: An Interdisciplinary Approach

The “Brain Tumors: An Interdisciplinary Approach” is the thirteenth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive volume on diagnosis and treatment of brain tumors. It starts with a general title on an interdisciplinary approach in brain tumors. Inherited genetics syndromes associated with central nervous system tumors as well as the impact of epigenetic methylation on gliomagenesis were explained. Then new approaches on precision medicine in brain tumors are discussed. After discussion on neurosurgical management of brain tumors, neuroimaging and radiosurgery of brain tumors are explained. Novel approaches to bypassing the blood-brain barrier for drug delivery to brain tumors are also discussed. After presentation of pediatric low-grade gliomas, treatment of glioblastoma is the subject of other chapters. The potential role of artificial intelligence in the treatment of glioblastoma is discussed in the last chapter. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for neurosurgeons and oncologists who wish to extend their knowledge on brain tumors.

Brain Tumors: An Interdisciplinary Approach

The “Neuroendocrine and Oral Cancers: An Interdisciplinary Approach” is the fourteenth volume of the “Interdisciplinary Cancer Research” series, publishes comprehensive volume on diagnosis and treatment of neuroendocrine tumors and oral cancers. The volume starts with a chapter on signaling pathways in neurological cancers and a general chapter on neuroendocrine neoplasms. Thyroid cancer and adrenal gland carcinoma as two examples of endocrine tumors are explained in this volume. The other chapters focus on oral cancers, where biomarkers for diagnosis and therapeutic opportunities are discussed. The last chapter also explains the challenges on oral and dental care on oncology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for neurologists, endocrinologists, dentists, oncologists who wish to have an update on diagnosis and treatment of endocrine tumors and oral cancers.

Neuroendocrine and Oral Cancers: An Interdisciplinary Approach

Hepatobiliary cancers, including hepatocellular&nbsp;carcinoma&nbsp;and&nbsp;biliary&nbsp;tract&nbsp;cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

Hepatobiliary cancers, including hepatocellular&nbsp;carcinoma&nbsp;and&nbsp;biliary&nbsp;tract&nbsp;cancers, have high rate of mortality and low survival rate. The third volume of the “Interdisciplinary Cancer Research” series, entitled “Hepatobiliary Cancers: An Interdisciplinary Approach” publishes comprehensive volumes on mechanisms of hepatobiliary cancers and therapeutic modalities and presents the most updated and peer-reviewed chapters on hepatobiliary cancers. This interdisciplinary series is of special value to researchers working on cell biology, immunology, biochemistry, genetics, and practitioners working on oncology and gastroenterology. This is the main concept of Cancer Immunology Project (CIP), which is a part of Universal Scientific Education and Research Network (USERN). This interdisciplinary book will be of special value for researchers, oncologists, and gastroenterologists who wish to extend their knowledge on hepatobiliary cancers.

Hepatobiliary Cancers: An Interdisciplinary Approach

The twelfth volume in the “Interdisciplinary Cancer Research” series, titled “Head and Neck Cancers: An Interdisciplinary Approach,” offers comprehensive reviews on the diagnostic and treatment of head and neck cancers. It begins with an overview of interdisciplinary methods in this field. The book also delves into the role of the microbiome and the evolving understanding of virus-immune system interactions in head and neck cancer. Other chapters focus on circulating tumor cells, extracellular vesicles, and circulating non-coding RNAs. Additionally, it discusses novel therapeutic targets, including lipid levels, oxidative stress, antihypoxic agents, and senotherapy. This volume is part of the Cancer Immunology Project (CIP), part of the Universal Scientific Education and Research Network (USERN), and it is particularly valuable for researchers, head and neck oncosurgeons, and oncologists looking to expand their knowledge in this area.

Head and Neck Cancers: An Interdisciplinary Approach

Very Short Introductions

Cancer is a problem that touches virtually everyone either directly or indirectly. As one of the biggest killers in the Western world it is feared by many people. In this Very Short Introduction, Nick James examines the trends and treatment of cancer, looking at efforts to develop treatments, research into cures, and the future of cancer care.

Cancer is a problem that touches virtually everyone either directly or indirectly. As one of the biggest killers in the Western world it is feared by many people. In this Very Short Introduction, Nick James examines the trends and treatment of cancer, looking at efforts to develop treatments, research into cures, and the future of cancer care.

A Very Short Introduction

Cancer

The book presents a unique and structured interdisciplinary approach, integrating insights from medicine, computer science, bioengineering, and other relevant fields. Due to this distinctive feature, the book offers a comprehensive exploration of the intricate relationship between potential AI applications and pain research and management. For example, one of its key aims is to provide valuable knowledge about AI for clinicians who may have limited familiarity with the subject, as well as for professionals in computer science and engineering. This approach is aimed at bridging the existing gap between these fields, offering clinicians insights into AI's potential applications, and providing computer scientists and engineers with a translational perspective on the practical needs in the clinical context. As widely demonstrated, the practical application of research faces a serious obstacle related to the limited communication and collaboration between research areas that are often very distant from each other. Therefore, this dual perspective could be useful to collocate the book as a valuable tool for fostering collaboration and understanding between these traditionally distinct domains.Furthermore, the structured framework of the book could not only facilitate learning but also serve as a foundation for future projects in the realm of AI and medicine. Specifically, it will be developed by following a framework useful for additional editorial projects, focusing more acutely on AI applications in anesthesia and critical care. By doing so, the book aims to contribute to the ongoing discourse and advancements in these specialized areas, filling a gap in the current literature. Therefore, the book seeks to make a meaningful contribution to the integration of AI in pain medicine, but also in other medical fields.

Exploring AI in Pain Research and Management

This book provides a comprehensive review of current knowledge on the pathophysiology, diagnostic techniques, and therapeutic strategies for salivary gland disorders. It highlights new evidence-based developments that are widely supported in the literature.In 28 chapters, the volume addresses a wide range of topics, including embryological development and anomalies, histology, surgical anatomy, and applied physiology of the salivary glands. Parotid gland topics include assessment and evaluation, traumatic injuries and fistulae, calculi, sialadenosis (sialosis), sialadenitis, cysts, tumors of the parotid gland, various techniques and potential complications of parotidectomy, including Frey's syndrome, and extra-temporal facial nerve reconstruction procedures. Likewise, topics of the submandibular gland cover evaluation, sialolithiasis, inflammatory disorders, sialadenosis, tumors, and different techniques and complications of submandibular sialadenectomy. In addition, two chapters discuss surgery of the sublingual gland and minor salivary glands.The book is structured to facilitate quick reference and to serve as a practical manual for clinicians of many specialties: head and neck surgeons, maxillofacial surgeons, orthopedic surgeons, endocrinologists, oncologists, and pediatricians. They will find this book to be a useful and indispensable resource as they face the most challenging salivary gland disorders, helping to provide individual patients with the best possible outcomes.

This book provides a comprehensive review of current knowledge on the pathophysiology, diagnostic techniques, and therapeutic strategies for salivary gland disorders. It highlights new evidence-based developments that are widely supported in the literature.In 28 chapters, the volume addresses a wide range of topics, including embryological development and anomalies, histology, surgical anatomy, and applied physiology of the salivary glands. Parotid gland topics include assessment and evaluation, traumatic injuries and fistulae, calculi, sialadenosis (sialosis), sialadenitis, cysts, tumors of the parotid gland, various techniques and potential complications of parotidectomy, including Frey's syndrome, and extra-temporal facial nerve reconstruction procedures. Likewise, topics of the submandibular gland cover evaluation, sialolithiasis, inflammatory disorders, sialadenosis, tumors, and different techniques and complications of submandibular sialadenectomy. In addition, two chapters discuss surgery of the sublingual gland and minor salivary glands.The book is structured to facilitate quick reference and to serve as a practical manual for clinicians of many specialties who treat patients with salivary gland disorders. Head and neck surgeons, maxillofacial surgeons, endocrinologists, oncologists, pediatricians, and clinicians from other specialties will find this book to be a useful and indispensable resource as they face the most challenging salivary gland disorders, helping to provide individual patients with the best possible outcomes.

Diagnostic and Therapeutic Strategies

Surgery of the Salivary Glands

Advances in Experimental Medicine and Biology

The book presents key topics at the forefront in breast development and cancer research in chapters authored by leading scientists in the field.The chapters provide a basis for understanding major concepts, model systems, cells of origin and heterogeneity in human breast development and cancer. The book builds on this understanding to guide readers through the cellular and molecular basis of breast cancer and the most important signaling pathways. Finally, the book describes mechanisms of metastasis and cancer immunity, and treatment options and resistance to therapy.It is targeted at young scientists and early career researchers and provides an overview of current topics in breast cancer research. Each chapter includes key learning points, boxes and conclusions to highlight the most important information. This book will interest anyone who wants to learn about the main areas of breast cancer research and the most important recent advances.

From Cellular Heterogeneity and Molecular Mechanisms to Therapy

A Guide to Breast Cancer Research

Recent Results in Cancer Research

After 10 years, this second edition is extensively rewritten and updated and provides a source of information concerning all aspects of medullary thyroid carcinoma, including comprehensive actual references for interested scientists.Medullary thyroid carcinoma (MTC) is a rare unique tumor which differs from other thyroid tumors by originating from the neuroendocrine C-cell, secreting the specific tumor marker calcitonin. MTC is associated in about 25% of cases with multiple endocrine neoplasia type 2, an autosomal dominant familial disorder causing tumors within various endocrine glands. The molecular genetics of tumor development is clarified: hereditary as well as sporadic MTC are linked to mutations in the RET proto- oncogene coding for a tyrosine kinase. These RET mutations serve as a genetic marker for hereditary MTC and allow for prophylactic thyroidectomy in gene carriers. The RET-tyrosine kinase is also a new therapeutic target using selective &nbsp;tyrosine kinase inhibitors improving the outcome of advanced metastasized MTC.&nbsp;This book will be an ideal source of up-to-date information for a wide range of practitioners, including endocrinologists, oncologists, internal medicine specialists, geneticists, and nuclear medicine physicians.

Biology, management, and treatment of sporadic and hereditary MTC

Medullary Thyroid Carcinoma

Imaging in Medical Diagnosis and Therapy

This book provides a comprehensive overview of computational methods used in radiation oncology and imaging physics, addressing clinical and research applications. It reflects the way in which technology has revolutionized these fields, for example showing how highly accurate model-based dose calculation engines are derived from transport theory, and how optimization tools enable delivery of highly conformal dose distributions, and how image processing, registration, and reconstruction tools are driving towards adaptive treatment planning. Readers will gain the skillset needed to adapt general mathematical techniques to real problems encountered in today's practice.

This book provides a comprehensive overview of computational methods used in radiation oncology and imaging physics, addressing clinical and research applications. It reflects the way in which technology has revolutionized these fields, for example showing how highly accurate model-based dose calculation engines are derived from transport theory, and how optimization tools enable delivery of highly conformal dose distributions, and how image processing, registration, and reconstruction tools are driving towards adaptive treatment planning. Readers will gain the skillset needed to adapt general mathematical techniques to real problems encountered in today’s practice.

Computational Methods in Radiation Oncology and Medical Imaging

This book is an up-to-date, single-volume, concise reference in ocular oncology. The book is divided into eight chapters. The first chapter is an introduction to oncology in general that covers basic concepts in cell biology, tumorigenesis, the hallmarks of cancer, and tumor pathology. The second chapter discusses the standard treatment methods employed in ocular oncology, including surgical approaches and techniques, treatment with physical energy such as radiotherapy, lasers, and cryotherapy, and the indications and toxicities of systemic and regional drug therapy. The following five chapters demonstrate the examination, classifications, clinical and imaging presentation, and current specific management options of tumors and relevant lesions that involve the eyelid, ocular surface, orbit, uveal tract, and retina. The final chapter highlights the direct and indirect impact of systemic cancers on the ophthalmic tissues and their management.

The book has been richly illustrated with over 350 original figures, schematic representations, and comparison tables.

Principles of Occular Oncology is a must-have resource for ocular oncology specialists and trainees, general ophthalmologists, and allied cancer care specialists who manage ophthalmic tumors.

This book is an up-to-date, single-volume, concise reference in ocular oncology. The book is divided into eight chapters. The first chapter is an introduction to oncology in general that covers basic concepts in cell biology, tumorigenesis, the hallmarks of cancer, and tumor pathology. The second chapter discusses the standard treatment methods employed in ocular oncology, including surgical approaches and techniques, treatment with physical energy such as radiotherapy, lasers, and cryotherapy, and the indications and toxicities of systemic and regional drug therapy. The following five chapters demonstrate the examination, classifications, clinical and imaging presentation, and current specific management options of tumors and relevant lesions that involve the eyelid, ocular surface, orbit, uveal tract, and retina. The final chapter highlights the direct and indirect impact of systemic cancers on the ophthalmic tissues and their management.The book has been richly illustrated with over 350 original figures, schematic representations, and comparison tables.Principles of Occular Oncology is a must-have resource for ocular oncology specialists and trainees, general ophthalmologists, and allied cancer care specialists who manage ophthalmic tumors.

Principles of Ocular Oncology

This book introduces an effective, affordable, non-invasive, and quick method to detect exposure to dangerous chemical carcinogens, which cause life-threatening conditions like cardiovascular, endocrine, neurological, hematological, dermatological, and malignant diseases. Nearly 20 million people are diagnosed with cancer annually, with almost 10 million deaths. While eliminating carcinogens completely is impossible, improving detection and monitoring—especially through specialized urine analysis—can help define preventive measures to lower carcinogen levels in the body.The chemical carcinogens discussed have been used for decades without proper evaluation of their health effects, costing millions of lives. Considering the long-term health impacts of current products is critical. Early detection is crucial as most carcinogens have cumulative effects. Identifying urinary markers of exposure can help detect, eliminate, or reduce sources of carcinogens, advancing preventive oncology.The book focuses on Group 1 chemical carcinogens classified by the International Agency for Research on Cancer (IARC). The described methods are highly effective, affordable, and applicable in any location with HPLC (High-Performance Liquid Chromatography) and ICP (Inductively Coupled Plasma) devices. They are non-invasive, requiring only urine samples, quick, and inexpensive.This volume aims to develop, improve, and implement screening methods for malignant diseases. It supports medical professionals in interpreting HPLC and ICP urinary analyses and providing guidance on reducing or avoiding carcinogen exposure. In some cases, doctors may identify sources of exposure and inform authorities to address and eliminate these hazards.

Diagnostic Approaches and Interpretation

Assessing Human Exposure to Key Chemical Carcinogens

This book encompasses the results of two decades of research on locoregional spread of gynecologic cancer, which put forth the ontogenetic cancer field model and its clinical translation in terms of ontogenetic tumor staging and cancer field surgery, particularly for carcinomas of the lower female genital tract. The ontogenetic cancer field model describes the propagation of malignant tumors within distinct permissive tissue regions determined by the development of the tissue from which the neoplasm originated. As the morphogenesis of multicellular animals proceeds stepwise through bifurcational cell fate specification within tissue regions dictated by the positional identity and plasticity of the precursor cell populations, tumor formation during malignant progression occurs as a stepwise process in the reverse direction with regard to positional identity and plasticity.This principle of order can be exploited for diagnosis, treatment and prognosis of cancer in general.The motivation to study in depth the topography of tumor spread arose from the insight that the conventional view of local cancer propagation as an unlimited isotropic process is falsified by numerous inconsistencies with clinical facts. Consequently, conventional cancer therapy based on this model cannot achieve optimal outcomes.The cancer field model and its application in gynecologic oncology has been published in highly ranked journals. However, the complexity of the principles and practice need the format of a well-structured book for their successful transmission to gynecologic surgeons, clinical oncologists, cancer researchers and postgraduate medical students.

Principles and Practice

Cancer Field Surgery in Gynecologic Oncology

Pizzo & Poplack's Principles and Practice of Pediatric Oncology

This comprehensive guide discusses the most frequent defects encountered in the surgical treatment of head and neck cancer, showcasing real clinical cases. It consistently highlights the clinical image and the histological diagnosis and outlines the key points to be considered when choosing the reconstruction technique. Each chapter delves into a specific surgical technique, offering a deep dive into its principles, applications, advantages, and outcomes. It also includes follow-up and short- and long-term results.From the Facial Artery Musculomucosal Flap (FAMM Flap) to the Gastric Pull-Up, the work presents reconstructive procedures using microsurgical and locoregional pedicled flaps, through a collection of 108 clinical cases, each accompanied by detailed descriptions, videos and over 500 stunning original surgical illustrations.Head and Neck Reconstructive Surgery is an essential resource for head and neck surgeons, plastic surgeons, cancer surgeons, oncologists, and anyone involved in restoring both form and function to patients with complex head and neck defects.“The basis of English translation of this book, originally in Portuguese, was&nbsp;facilitated by artificial intelligence. The content was later revised by the author for accuracy.”

This comprehensive guide discusses the most frequent defects encountered in the surgical treatment of head and neck cancer, showcasing real clinical cases. It consistently highlights the clinical image and the histological diagnosis and outlines the key points to be considered when choosing the reconstruction technique. Each chapter delves into a specific surgical technique, offering a deep dive into its principles, applications, advantages, and outcomes. It also includes follow-up and short- and long-term results.From the Facial Artery Musculomucosal Flap (FAMM Flap) to the Gastric Pull-Up, the work presents reconstructive procedures using microsurgical and locoregional pedicled flaps, through a collection of 108 clinical cases, each accompanied by detailed descriptions, videos and over 500 stunning original surgical illustrations.Head and Neck Reconstructive Surgery is an essential resource for head and neck surgeons, plastic surgeons, cancer surgeons, oncologists, and anyone involved in restoring both form and function to patients with complex head and neck defects.&nbsp;

A Comprehensive Clinical Case Guide

Head and Neck Reconstructive Surgery

Oxford Medical Handbooks

Oxford Handbook of Oncology

Cancer Metastasis, Management and Complications: An Interdisciplinary ...

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