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Catalogue complet

Drug Discovery Update

Antidotes to Toxins and Drugs

From Natural Sources to Drug Discovery in Toxicology

Biochemical and Molecular Pharmacology in Drug Discovery comprises fundamental biochemical and molecular aspects of drug discovery and basic understanding of modern drug discovery approaches, along with certain key topics related to molecular pharmacology of drugs and therapeutics. The book explains the phenomena of drug-target interactions, considering different biochemical systems and cellular strategies. With the advent of technologies, current advances, and research trends move toward molecular and/or target-based drug design and discovery. Through this book, readers will gain skills and knowledge with a thorough understanding of the subject of biochemical and molecular pharmacology in a comprehensive and systematic manner. Molecular pharmacology has gained significant momentum among researchers, scientists, and academicians because of its increasing interest in drug discovery research across the globe. Molecular pharmacology involves a fundamental understanding of drug actions at the molecular level with the help of several tools and techniques of biochemical and molecular biology.

Biochemical and Molecular Pharmacology in Drug Discovery

Volume 3: Druggable Targets and In Silico Update

Coronavirus Drug Discovery

CRC Handbook of Chemistry and Physics

High Quality Science requires High Quality Data! Today, more than ever, the CRC Handbook of Chemistry and Physics is critical in ensuring that researchers, educators, and students have the highest quality data for chemical compounds and physical particles. Available both in print and online, the Handbook covers 390 chemistry, physics, and related subjects organized in easy-to-find, well-organized tables. Every year, new reported data and new scientific areas are added, making the Handbook the largest comprehensive physical science data source available anywhere. Handbook features include:<ul> <li>All data reviewed and evaluated by subject matter experts</li> <li>Standardized chemical names, structures, property names, and property units </li> <li>Important information on subjects such as chemical and laboratory safety, and nomenclature</li> <li>Chemical and physical data critical for fields such as environmental science, bio-medical chemistry, organic and inorganic chemistry, materials innovation, geo- and astrophysics, and solid-state science</li> <li>Digital tools in our Online Edition to analyze, graph, process, and exploit our data content </li> </ul>

One-stop reference on homogeneous catalysis, from general concepts through detailed examples and industrial applications Accessible and richly illustrated, Applied Homogeneous Catalysis provides a concise overview of the broad field of homogeneous transition metal catalysis and its applications in the chemical industry. This newly revised and updated second edition puts special emphasis on green chemistry, sustainable resources, and processes. The book is divided into five parts. Part I presents the basics of transition metal catalysis. Part II focuses on process engineering aspects. Part III provides details of the most important catalytic reactions. Part IV describes catalytic conversions closely related to classical homogeneous transition metal catalysis, such as nano-, electro-, photo- and organocatalysis. Part V covers new feedstocks and other topics, concluding with an outlook on future challenges of homogeneous catalysis. The book contains numerous mechanistic details, technical information, and illustrative examples. The chapters are enlivened by various excursions that relate the content to everyday life or introduce important personalities. Didactically, the book is completed with learning objectives and take-home messages for each chapter, as well as more than 400 questions and answers for self-testing. Written by a team of internationally renowned experts in the field, with a wealth of experience in industry and teaching, Applied Homogeneous Catalysis includes information on: <ul><li>Economic importance of industrial homogeneously-catalyzed reactions and basics of organometallic chemistry, including types of bonds, elemental steps, and mechanisms</li> <li>Common approaches for separating the homogeneous catalyst from the products after the reaction and using combinatorial chemistry and high throughput screening to achieve optimal results</li> <li>Activating "inactive" molecules such as carbon dioxide and nitrogen, and harnessing homogeneous catalysis for feedstock diversification by recycling polymers or using renewables.</li></ul> Providing expansive coverage of the subject, Applied Homogeneous Catalysis is an essential guide for researchers and professionals in the pharmaceutical, polymer, and fine and bulk chemicals industries working on catalysis or entering the field, as well as for Master's and PhD students in organic chemistry, chemical engineering, and related fields.

One of the key catalysis books both for students and researchers as well as professionals in industry, covering homogeneous catalysis from general concepts through detailed examples and industrial applications.

A Tool for Sustainable Chemistry

Applied Homogeneous Catalysis

This handbook identifies many changes in regulations and recommends ways to apply and implement them. Containing the latest environmental information, the second volume addresses environmental compliance with Water and provides a historical perspective to help follow the logical growth and increased complexity of Water regulations through time.

Water

Environmental Compliance Handbook, Volume 2

Organic chemistry can be a challenging subject. Most students view organic chemistry as a subject requiring hours upon hours of memorization. Author David Klein's Second Language books prove this is not true-organic chemistry is one continuous story that makes sense if you pay attention. Offering a unique skill-building approach, these market-leading books teach students how to ask the right questions to solve problems, study more efficiently to avoid wasting time, and learn to speak the language of organic chemistry. Covering the initial half of the course, Organic Chemistry as a Second Language: First Semester Topics reviews critical principles and explains their relevance to the rest of the course. Each section provides hands-on exercises and step-by-step explanations to help students fully comprehend classroom lectures and textbook content. Now in the 6th edition, there are approximately 30 new end-of-chapter exercises in each chapter. These new exercises vary in difficulty, starting with exercises that focus on just one skill or concept (called Practice Problems), and continuing with exercises that focus on more than one skill or concept (called Integrated Problems), and concluding with advanced exercises (called Challenge Problems). There are also author-created, detailed solutions for all new exercises, and these detailed solutions appear in the back of the book.

First Semester Topics

Organic Chemistry as a Second Language

Scent and Chemistry Odor impressions have cast a spell over mankind since the dim and distant past. But even today, we are -consciously or subconsciously- guided by our sense of smell and the chemistry behind it. The prominent fragrance chemists Günther Ohloff, Wilhelm Pickenhagen and Philip Kraft convey the scientist, the perfumer, and the interested layman with a vivid and up-to-date picture of the chemistry of odorants and the research in odor perception. In this second thoroughly revised and updated edition they are joined by creative perfumer Fanny Grau, a rising master in this métier, who complements the scientific treatise by a concise introduction to the art of perfumery and its composition techniques. Besides this new chapter on the creative aspects of perfumery, the book details on the molecular basis of olfaction, olfactory characterization of perfumery materials, structure-odor relationships, the chemical synthesis of odorants, and the chemistry of essential oils and odorants from the animal kingdom, backed up by many perfume examples and historical aspects. It will serve as a thorough introductory text for everyone interested in the molecular world of odors.

The book details the molecular basis of olfaction, olfactory characterization or perfumery materials, structure-odor relationships, chemical synthesis of odorants, and chemistry of essential oils and odorants from the animal kingdom, backed up by many examples from perfumery and historical aspects.

The Molecular World of Odors

Scent and Chemistry

Chemistry's most significant chart, the Periodic Table, and its 118 elements, is laid bare in this lively, accessible and compelling expose. The periodic table, created in the early 1860s by Russian chemist Dmitri Mendeleev, marked one of the most extraordinary advances in modern chemistry. This basic visual aid helped scientists to gain a deeper understanding of what chemical elements really were and the role they played in everyday life. Here, in the authoritative Elementary, James Russell uses his engaging narrative to explain the elements we now know about. From learning about the creation of the first three elements, hydrogen, lithium and helium, in the big bang, through to oxygen and carbon, which sustain life on earth - along with the many weird and wonderful uses of elements as varied as fluorine, arsenic, krypton and einsteinium - even the most unscientifically minded will be enthralled by this fascinating subject. This is the story of the building blocks of the universe, and the people who identified, isolated and even created them.

Authoritative science to engage even the most unscientific! Chemistry's most significant chart, the Periodic Table and its 118 elements, is laid bare in this lively accessible and compelling expose.

The Periodic Table Explained

Elementary

RYOJI NOYORI, born in Kobe in 1938, accepted the challenge to look back upon his life. He saw himself living in poverty and often struggling during and after WW&nbsp;II. He saw his parents and their friends guiding and inspiring him. He saw himself climbing up the ranks at the universities in Kyoto and Nagoya, deeply embedded in the Japanese culture.He saw himself conquering organic synthesis and asymmetric homogeneous catalysis as well as green chemistry. Formative was his time with Nobel laureate E.&nbsp;J. Corey at Harvard where he was exposed to a completely different culture. Back in Nagoya, Noyori's scientific success continued and culminated in receiving the Nobel Prize in 2001.His extraordinary care about Japan's science led to his second career, first as President of RIKEN, Japan's largest research institution, and then as a leading figure to many governmental and industrial organizations. The basis of all his activities is a deep sense of responsibility for the society at large and the next generation of scientists.

Lives in Chemistry

Research Should Be Fresh, Simple, and Clear

Teaches students to solve problems in Organic Chemistry using methods of analysis that are valuable and portable to other fields Electron Flow in Organic Chemistry provides a unique decision-based approach that develops a chemical intuition based on a crosschecked analysis process. Assuming only a general background in chemistry, this acclaimed textbook teaches students how to write reasonable reaction mechanisms and use analytical tools to solve both simple and complex problems in organic chemistry. As in previous editions, the author breaks down challenging organic mechanisms into a limited number of core elemental mechanistic processes, the electron flow pathways, to explain all organic reactions-using flow charts as decision maps, energy surfaces as problem space maps, and correlation matrices to display all possible interactions. The third edition features entirely new chapters on crosschecking chemical reactions through good mechanistic thinking and solving spectral analysis problems using organic structure elucidation strategies. This edition also includes more biochemical reaction mechanism examples, additional exercises with answers, expanded discussion of how general chemistry concepts can show that structure determines reactivity, and new appendix covering transition metal organometallics. Emphasizing critical thinking rather than memorization to solve mechanistic problems, this popular textbook: <ul><li>Features new and expanded material throughout, including more flowcharts, correlation matrices, energy surfaces, and algorithms that illustrate key decision-making processes</li> <li>Provides examples from the field of biochemistry of relevance to students in chemistry, biology, and medicine</li> <li>Incorporates principles from computer science and artificial intelligence to teach decision-making processes</li> <li>Contains a general bibliography, quick-reference charts and tables, pathway summaries, a major decisions guide, and other helpful tools</li> <li>Offers material for instructors including a solutions manual, supplemental exercises with detailed answers for each chapter usable as an exam file, and additional online resources</li></ul> Electron Flow in Organic Chemistry: A Decision-Based Guide to Organic Mechanisms, Third Edition, is the perfect primary textbook for advanced undergraduate or beginning graduate courses in organic reaction mechanisms, and an excellent supplement for graduate courses in physical organic chemistry, enzymatic reaction mechanisms, and biochemistry.

Electron Flow in Organic Chemistry

Teaches students to solve problems in Organic Chemistry using methods of analysis that are valuable and portable to other fields

Electron Flow in Organic Chemistry provides a unique decision-based approach that develops a chemical intuition based on a crosschecked analysis process. Assuming only a general background in chemistry, this acclaimed textbook teaches students how to write reasonable reaction mechanisms and use analytical tools to solve both simple and complex problems in organic chemistry. As in previous editions, the author breaks down challenging organic mechanisms into a limited number of core elemental mechanistic processes, the electron flow pathways, to explain all organic reactions--using flow charts as decision maps, energy surfaces as problem space maps, and correlation matrices to display all possible interactions.

The third edition features entirely new chapters on crosschecking chemical reactions through good mechanistic thinking and solving spectral analysis problems using organic structure elucidation strategies. This edition also includes more biochemical reaction mechanism examples, additional exercises with answers, expanded discussion of how general chemistry concepts can show that structure determines reactivity, and new appendix covering transition metal organometallics. Emphasizing critical thinking rather than memorization to solve mechanistic problems, this popular textbook:
* Features new and expanded material throughout, including more flowcharts, correlation matrices, energy surfaces, and algorithms that illustrate key decision-making processes
* Provides examples from the field of biochemistry of relevance to students in chemistry, biology, and medicine
* Incorporates principles from computer science and artificial intelligence to teach decision-making processes
* Contains a general bibliography, quick-reference charts and tables, pathway summaries, a major decisions guide, and other helpful tools
* Offers material for instructors including a solutions manual, supplemental exercises with detailed answers for each chapter usable as an exam file, and additional online resources

Electron Flow in Organic Chemistry: A Decision-Based Guide to Organic Mechanisms, Third Edition, is the perfect primary textbook for advanced undergraduate or beginning graduate courses in organic reaction mechanisms, and an excellent supplement for graduate courses in physical organic chemistry, enzymatic reaction mechanisms, and biochemistry.

A Decision-Based Guide to Organic Mechanisms

Electron Flow in Organic Chemistry

It is more than 10 years since the 7th Edition published in 2013, and plenty has changed in the field of ice cream and frozen desserts. The phenomenal growth of "better for you" and "non-dairy" frozen dessert categories, and the much greater attention to microbiological quality, are just some examples. In this revision, we updated all content to present the latest in ingredients, formulations, processing equipment and food safety, as well as add several new chapters to provide a more complete coverage of the wider aspects of frozen dessert formulation and production.

Ice Cream

de Gruyter Textbook

In chemistry, good problem-solving requires a balanced combination of scientific intuition and methodical analysis. Additionally, thoughtfully presented diagrams and infographics can convey a large amount of complex information in a more intuitive and accessible manner. 100 Must-Know Mechanisms (Second Edition) strives to be at the intersection of these two key principles. Its thorough visualizations enable experienced readers to use it as a quick reference for specific mechanisms of interest. At the same time, the book's breadth of covered reactions, from classic to cutting-edge, make it a good study-aid for the developing chemist. A slow and consistent study of the entire series of mechanisms can help set the foundation for good scientific intuition, while its detailed infographics and careful navigation features encourage coming back to it frequently. This edition includes over 40 new illustrations, numerous new mechanistic schemes, enhanced original figures with a variety of real-case examples, and more

Organic Chemistry: 100 Must-Know Mechanisms

Morphin - das Geschenk Morpheus.- Kokain - von der Droge zum Lokalanästethikum.- Aspirin - das meistverwendete Arzneimittel in der Geschichte der Menschheit.- Steroide und die Pille.- Koffein und Viagra.- Chinin.- Cumarine - vom Rattengift zum Arzneimittel für den Präsidenten.- Naturstoffe als Ausgangsstoffe für die Arzneisynthese.- Moderne Arzneistoffforschung.- Sind Drogen nur schlecht?- Heilende Gifte.

Naturstoffe sind ein Wunderwerk der Evolution. Pflanzen sind chemische Fabriken und haben mit ihren außergewöhnlichen Eigenschaften eine riesige Anzahl sehr vielfältiger interessanter Naturstoffe hervorgebracht, die wir Menschen seit Jahrhunderten zur Linderung und Heilung von Krankheiten nutzen. Spätestens seit der Entdeckung des Penicillins sind Naturstoffe zu einer wichtigen Quelle für Medikamente geworden, aber wir kennen nur sehr wenige der vermutlich vielen Millionen, die auf ihre Entdeckung warten. Zu den Naturstoffen gehören wichtige Antibiotika, Immunsuppressiva, Antikrebsmittel, Hormone und auch antivirale Wirkstoffe. Aber haben Naturstoffe im Zeitalter der Bio- und Gentechnologie überhaupt noch eine Bedeutung? Ja, mehr denn je, denn Medizinalchemiker holen sich kreative Anregungen für ihre Synthesen aus der Natur, um den nächsten Blockbuster in der Medizin zu entwickeln.&nbsp;
 
 Oliver Kayser erzählt in diesem Buch die Geschichte der Naturstoffe und Medizinpflanzen auf höchst informative und amüsante Weise aus einem neuen Blickwinkel. Er geht der Frage nach, wie Naturstoffe aus der Naturheilkunde die pharmazeutische Industrie ins Leben riefen, wie sie als Arznei- und Heilmittel unsere Gesellschaft prägten, wie sie Kriege ermöglichten und den Weg zu Nobelpreisen ebneten. Der Autor zeichnet ein faszinierendes Panorama der Naturstoffchemie in Pflanzen, Mikroorganismen und Tieren. Beginnend mit den ersten Isolierungen zu Anfang der industriellen Revolution führt er uns mit den Ideen und der Begeisterung vieler Wissenschaftlerinnen und Wissenschaftler in die Moderne der Wirkstofftests, der Computerchemie und der höchst erfolgreichen Zufallsentdeckungen von Wirkstoffen. Die Naturstoffforschung im Labor hat einen enormen Einfluss auf unser heutiges Leben. Der Autor lässt sich über die Schulter schauen, wie heute die Suche nach den neuen Medikamenten von morgen funktioniert. Das Buch ist das ultimative Buch aus der Feder eines Wissenschaftlers, der tief in der Forschung verwurzelt ist und dem Leser einen erhellenden und zugleich kurzweiligen Einblick gibt, wie Wissenschaftler ticken und wie mühsam Forschung sein kann.

Wie Naturstoffe Geschichte schreiben

Von den Molukken zu Molekülen

Leading reference on the theories of organic chemistry, now updated to reflect the most recent literature from 2018 to 2023 Building on the success of the 8th Edition as winner of the Textbook &amp; Academic Authors Association 2021 McGuffey Longevity Award, the revised and updated 9th Edition of March's Advanced Organic Chemistryexplains the theories of organic chemistry, covers new advances in areas of organic chemistry published between 2018 and 2023, and guides readers to plan and execute multi-step synthetic reactions. Detailed examples and descriptions of all reactions are included throughout the text. As in previous editions, the goal of this edition is to give equal weight to three fundamental aspects of the study of organic chemistry: reactions, mechanisms, and structure. Specific but specialized areas of organic chemistry, such as terpenes, polymerization, and steroids, have been incorporated into primary sections rather than segregated into their own sections. The first nine chapters cover general organic chemistry with theoretical principles. The next 10 chapters address reactions and mechanistic discussion. Appendix A focuses on literature references and resources. More than 4,400 references are included throughout the text. March's Advanced Organic Chemistry provides information on: <ul><li>Localized and delocalized chemical bonding and bonding weaker than covalent</li><li>Microwave chemistry, use of ultrasound, mechanochemistry, and reactions done under flow conditions</li><li>Acids and bases, irradiation processes, stereochemistry, structure of intermediates, and ordinary and photochemical reactions</li><li>Mechanisms and methods of determining carbocations, carbanions, free radicals, carbenes, and nitrenes</li><li>Aliphatic, alkenyl, and alkynyl substitution, additions to carbon-carbon and carbon-hetero bonds, eliminations, rearrangements, and oxidations and reductions</li></ul> This 9th Edition of March's Advanced Organic Chemistry continues to serve as a must-have reference for every student and professional working in organic chemistry or related fields.

Reactions, Mechanisms, and Structure

March's Advanced Organic Chemistry

Antidotes to Toxins and Drugs

Weitere Titel der Reihe: Drug Discovery Update

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