This work brings together European science and administration to explore the digital and sustainable transformation of the European Union, from the smallest municipality to the EU Commission. The contributions analyse the complex interactions and concrete options for action between science, administration, and society from the perspectives of political science, law, and economics: how the EU is driving the transformation and what specific opportunities and risks are emerging in various areas, from energy policy and biodiversity to the regulation of artificial intelligence and the development of smart cities. The book shows how this transformation can be successfully managed.