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Henderson B: The Human Microbiota and
Chronic Disease – Dysbiosis as a Cause

The Human Microbiota and Chronic Disease – Dysbiosis as a Cause of Human Pathology

Species and Systematics

A goal of macroevolutionary theory is to explain both diversity and disparity - different sometimes uncorrelated characteristics of lineages. These actively researched questions, the growing number of case studies, and the increasingly rigorous theory, has resulted in the re-examination of classical models for evolutionary tempo and mode. Time-calibrated molecular phylogenies are now used in conjunction with quantitative analyses of morphology to evaluate models of evolution. For example, mathematically simple efforts to understand biologically complex traits (such as body size) are common. The major objective of the proposed work is to present novel methods and case-studies of the tempo and mode of evolution of complex morphologies. Recent innovations in methods for describing and modeling complex morphologies, which have the potential to advance the field still further, will be the primary focus of this intended volume.

A goal of macroevolutionary theory is to explain both diversity and disparity. These actively researched questions, the growing number of case studies, and the increasingly rigorous theory, has resulted in the re-examination of classical models for evolutionary tempo and mode. Time-calibrated molecular phylogenies are now used in conjunction with quantitative analyses of morphology to evaluate models of evolution. This book will present novel methods and case-studies of the tempo and mode of evolution of complex morphologies, including recent innovations in methods for describing and modeling complex morphologies, which have the potential to advance the field still further.Key selling features:<ul> <li>Explores the relationship, if any, between species diversity and morphological disparity</li> <li>Includes relevant case studies</li> <li>Documents the role of geography and ecology in generating or retarding diversity and disparity</li> <li>Evaluates contingent, deterministic and intrinsic controls on macroevolutionary patterns</li> <li>Reviews models that predict diversity and disparity</li> </ul>

Macroevolution of Complex Morphologies

Chapman & Hall/CRC Monographs on Statistics and Applied Probability

Significant new challenges to the use of likelihood-based methods for inference have helped to generate considerable interest in alternative inference methods that are not based on a full likelihood specification. This book provides a comprehensive survey of likelihood methods in statistics, with an emphasis on developments to inference functions for use in complex data. These inference functions are usually motivated by considerations related to likelihood-type arguments and have a variety of names, including composite likelihood, quasi-likelihood and pseudo-likelihood.

Significant new challenges to the use of likelihood-based methods for inference have helped to generate considerable interest in alternative inference methods that are not based on a full likelihood specification. This book provides a comprehensive survey of likelihood methods in statistics, with an emphasis on developments to inference functions for use in complex data. These inference functions are usually motivated by considerations related to likelihood-type arguments and have a variety of names, including composite likelihood, quasi-likelihood and pseudo-likelihood.

Likelihood and its Extensions

Living in Sync With Our Circadian Rhythms

The Inner Clock

Debating the use of genomic tools and their societal impactOver the past decade, the field of human genetics has produced an extraordinary range of discoveries-including the refinement of polygenic scores, which use a person's DNA to estimate their likelihood of developing a trait or disease. But are these new technologies ready to leave the research lab and be deployed in schools, fertility clinics, and the wider world? In What We Inherit, Sam Trejo and Daphne Martschenko offer different perspectives on the societal impact of the rapidly unfolding DNA revolution. Trejo, a sociologist and expert on the complex ways people's genes influence their life's trajectory, believes that new genomic tools-if used thoughtfully-can improve society; Martschenko, a bioethicist who specializes in the thorny social issues raised by biomedical advances, is more cautious. They debate both the risks and the opportunities posed by such new technologies as at-home genetic tests and polygenic embryo selection-all while engaging in a wide-ranging dialogue on ideology, biology, and social inequality. While grappling with these new technologies, Trejo and Martschenko remind us that we inherited from our ancestors not only DNA but also wrong-headed ideas about genes. Together, they caution against two particularly harmful genetic myths: that genes determine an individual's future, and that race and genetics are inherently connected. A polygenic score, for example, is not a definitive marker for disease. And race is a sociopolitical construct, not a biological identity. Trejo and Martschenko argue that, to avoid exacerbating social inequality, we need to begin regulating genomic tools sooner rather than later.

How New Technologies and Old Myths Are Shaping Our Genomic Future

What We Inherit

This book offers a review and analysis of contemporary forensic investigation, written for students, from the perspective of the practitioner, focusing on the core functions of forensic investigation and the impact of change in the forensic context.

This book offers a review and analysis of contemporary forensic investigation, written for students, from the perspective of the practitioner, focusing on the core functions of forensic investigation and the impact of change in the forensic context.

Contemporary Forensic Investigation

The first major publication on mass fatality management when it was published in 1999, the new edition of this bestseller is greatly revised and expanded. Eight new chapters include such topics as international resources, multi-national events, data management, identification management, repatriation, mass burial, and management of contaminated human remains. This revision is based on world events of the past 15 years, many of which the author managed. It includes expanded information on morgue operations, reflects increasing sensitivity to cultural differences, and provides the latest direction for handling the media.

The first major publication on mass fatality management when it was published in 1999, the new edition of this bestseller is greatly revised and expanded. Eight new chapters include such topics as international resources, multi-national events, data management, identification management, repatriation, mass burial, and management of contaminated human remains. This revision is based on world events of the past 15 years, many of which the author managed. It includes expanded information on morgue operations, reflects increasing sensitivity to cultural differences, and provides the latest direction for handling the media.

A Field Guide, Second Edition

Mass Fatality and Casualty Incidents

Written by the editor of the Journal of Forensic Medicine and Toxicology, this practical book explains how to avoid such pitfalls of the medical professions as failure to diagnose, confidentiality, disclosure of information, lack of informed consent, and poor documentation. It aids doctors in all disciplines to become proactive in managed care, expert testimony, and medical malpractice. Citing case law both in the US and abroad gives the book global appeal.

Written by the editor of the Journal of Forensic Medicine and Toxicology, this practical book explains how to avoid such pitfalls of the medical professions as failure to diagnose, confidentiality, disclosure of information, lack of informed consent, and poor documentation. It aids doctors in all disciplines to become proactive in managed care, expert testimony, and medical malpractice. Citing case law both in the US and abroad gives the book global appeal.

An International Approach

Legal Issues in Medicine

Training in clinical chemistry is acquired via different avenues that include didactic lectures on pathophysiology of disease, methodologies and practical aspects of testing, and through attendance of operations meetings, sign-out sessions, seminars and tutorials. There is little instruction on how to apply the vast amount of knowledge gained in the process to practice. In other branches of medicine, cases are regularly presented with clinical information and therapeutic interventions which form the basis of training. Diagnostic Reasoning: Laboratory-Based Case Studies in Clinical Chemistry fills this gap for clinical chemistry. The concise and practical approach of the book, including real-life scenarios, is an excellent resource for pathology trainees, clinical laboratory science students, clinical chemistry fellows, clinical laboratory professionals, and clinicians. These cases help professionals remain competent in the field and be successful in their board exams. The cases are stated as they present, often with no or few clinical details accompanying the sample request with only barcoded samples arriving into the laboratory. In a busy laboratory, thousands of these cases are received daily and it is impossible to review the clinical information associated with the specimens.

Laboratory-Based Case Studies in Clinical Chemistry

Diagnostic Reasoning

Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep. Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

Glial Mechanisms in Sleep and Circadian Biology

A Computational Approach

Modeling Structure-Function Relations in Ion Channels

This book is designed as a companion to Skeletal Trauma Identification of Injuries Resulting from Human Rights Abuse and Armed Conflict. While the larger reference is exhaustive in many ways, there are so many cases from around the world it is impossible to provide them in a single volume. This supplement offers the complete version of the cases summarized in the larger reference. It may be used as both a stand-alone book and also a secondary text in forensic anthropology courses.

Case Studies in Skeletal Trauma Resulting from Human Rights Abuses and Armed Conflict

Aortic Valve Repair provides a comprehensive summary on techniques developed during the first 500 cases of aortic ring annuloplasty. Aortic valve disease is usually surgically managed by aortic valve replacement, and it is well established in published literature regarding the long-term results, survival rate, durability of the protheses and reoperations rates. Over the past two decades, aortic valve repair (AVr) has evolved into a recognized surgical option for selected patients with aortic insufficiency or proximal aorta aneurysm. Studying the first 500 cases of aortic ring annuloplasty, the authors provide the most effective methods of leaflet and aortic root reconstruction to repair pathologies. Including original illustrations and videos, the book serves as an essential reference for cardiac surgeons in practice.

Aortic Valve Repair

The Human Microbiota and Chronic Disease – Dysbiosis as a Cause of ...

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