We have been dependent on plants for food, furniture, construction, and fuel since prehistoric times. Plants in all forms have tendered their services to mankind. Humans have selected plants based on their value and potential for domestication. People living on different continents of the world use plants to treat various diseases and various systems of medicines were generated, including the Ayuvedic, Unani, Chinese systems of medicines. Due to the advancement of science and technology, various non-conventional methods to treat diseases were also identified. Each system of medicine has advantages and disadvantages. Systems that utilized plant based natural products for the discovery of drugs have attracted attention across globe due to their minimal or lack of side effects.