This book describes airway diseases, prevalence, pathophysiology, and therapeutic options, then explores the link between lipid metabolites and airway disease. It examines the cellular lipid metabolic machinery carefully and evaluates the research for and against important constituents to act as targets for drug discovery for treating airway diseases. It covers preclinical drug discovery efforts around well known and not so conventional lipid targets. It discusses molecules that have gone into clinical trial and become successful drugs as well as those that were not successful, giving readers an understanding of the drug discovery approach while discussing targets.