The Mayo Clinic Atlas of Regional Anesthesia and Ultrasound-Guided Nerve Blockade is a practical guide that vividly illustrates a systematic approach to regional anaesthesia of the upper and lower extremity while providing a comprehensive overview of the fundamental principles of ultrasonography, relevant Sonoanatomy of the upper and lower extremity, and the technical skills necessary to become clinically proficient at ultrasound-guided regional anaesthesia.