<div class="raw-html-embed"> Kennen Sie schon unseren Geschäftskundenservice? <a href="/fuer-geschaeftskunden">Wir beraten Sie gerne</a>.</div>

NL_Doormat: Hintergrundfarbe des Newsletter Banners unten in der Doormat. Mit # eingeben z.B. #1405BE

NL_Doormat: Verlinkung zur Newsletter Seite

Über uns

À propos de nous

Zahlung und Lieferung

Paiement et livraison

Nachhaltigkeit

Durabilité

Open Access

Datenschutz

Protection des données

Karriere

Carrière

Impressum

Mentions légales

LEXIA

LEXIA Arbeitsrecht

Was ist LEXIA?

C'est quoi LEXIA ?

LEXIA Familienrecht

Zeitschriften

Revues

recht

Pflegerecht

ZBJV

forumpoenale

ZStrR

Anwaltsrevue

Revue de l'avocat

RSAS

FamPra.ch

ASYL

Life Science Recht

BlAR

Sachbuch

Livres spécialisés

LOKI

Semaphor

Fokusthemen

Focus

Thema

Recht studieren

Arbeitsrecht

Droit du travail

Studium

Études

Familienrecht

Droit de la famille

Sozialversicherungsrecht

Droit des assurances sociales

Strafrecht

Droit pénal

Publikationen

Publications

Literatur

Onlinemodule LEXIA

Modules en ligne LEXIA

Bücher

Livres

Buchreihen

Collections

Datenbanken

recht.ch

Studienliteratur

Littérature pour les études

Services

Dienstleistungen für

Corporate Books

Publishing Lösungen

Aktuelles

Geschäftskunden

Professionnels

Corporate Publishing

Content solutions

Buchhandlungen

Librairies

Veranstaltungen

Événements

Presse

Dozierende

Enseignants

Studierende

Étudiants

Inserierende

Annonceurs

Newsletter

Blog

Autorinnen/Autoren

Auteurs

Unsere Schreibenden

Hilfe

Unsere Autorinnen und Autoren

Liste

Autorenlounge

Espace des auteurs

Bei uns publizieren

Publier chez nous

Autorenstimmen

Témoignages

Verlag

Éditions

Themen

Mehr wissen

Mitarbeitende

Collaborateurs

Geschichte

Histoire

Vision und Mission

Vision et mission

Unser Magazin

Notre magazine

Unternehmenskultur

Culture d'entreprise

Partner

Partenaires

Kontakt

Contact

Shop

Schweizer Recht

Ausländisches Recht

Über unseren Shop

Neuerscheinungen

Nouveautés

Sortiment und Funktionen

Assortiment et recherche

Vorankündigungen

À paraître

Nach Rechtsgebiet

Par domaine juridique

Kommentare

Commentaires

Oxidative Stress and Disease

Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although beneficial, overproduction drives development of pathologies, by triggering the initiation of stress-related cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, and their involvement in immunity and disease.

Mammalian heme peroxidase enzymes are critical for immune responses and disease prevention. Although beneficial, overproduction drives development of pathologies, by triggering the initiation of stress-related cell damage and dysfunction. This book highlights the roles of mammalian heme peroxidases, and their involvement in immunity and disease.

Mammalian Heme Peroxidases

Diverse Roles in Health and Disease

SECTION 1: INTRODUCTION TO MAMMALIAN HEME PEROXIDASES Structure, function, phylogeny of heme peroxidases Biosynthesis of MPO and other heme peroxidases Peroxidasin structure and function SECTION 2: REACTIVITY OF PEROXIDASE OXIDANTS Reactivity of peroxidase oxidants with proteins and proteoglycans Reactivity of peroxidase with nucleic acids, RNA and DNA Reactivity of peroxidase oxidants with lipids - modification and signaling Role of MPO in the modification of lipoproteins (LDL and HDL) Regulation of cellular signaling and survival by peroxidase oxidants Global profiling of cell responses to peroxidase oxidants SECTION 3: PEROXIDASES IN INNATE IMMUNITY MPO and immune cell recruitment and activation Role of MPO in extracellular trap release by neutrophils Imaging HOCl production by neutrophils How microbes combat reactive chlorine species Priming the innate immune system to combat respiratory disease SECTION 4: PEROXIDASES IN PATHOLOGY Imaging the reactivity of MPO in vivo Role of MPO in vascular dysfunction and signaling MPO in ischemic heart disease Role of MPO in neurodegenerative disease Role of MPO in kidney disease Role of peroxidases in respiratory disease Role of peroxidasins in disease SECTION 5: PREVENTION OF MPO INDUCED DAMAGE Design and functionality of MPO inhibitors Modulation of disease using MPO inhibitors Novel peroxidase inhibitory protein "SPIN" with broad target specificity Selenium and resistance to oxidative enzyme inactivation

Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. This book provides an up-to-date review of the role of o

Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. This book provides an up-to-date review of the role of o

Lipid Oxidation in Health and Disease

There is now a large amount of data available for human beings, showing health beneficial hormetic effects of mild stresses from physical, chemical, nutritional, and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full apprehension and application. A compr

There is now a large amount of data available for human beings, showing health beneficial hormetic effects of mild stresses from physical, chemical, nutritional, and mental sources. However, these data are dispersed in the literature and not always interpreted as hormetic effects, thus restricting their full apprehension and application. A compr

Hormesis in Health and Disease

This book unravels key physiological responses and adaptations to different redox regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease.

This book unravels key physiological responses and adaptations to different redox regulated exercise paradigms at the cell, tissue, and whole-body level in model systems and humans in health and disease.

Oxidative Eustress in Exercise Physiology

This book reviews the interrelation between plasma chemistry and biochemistry complemented by discussion of the ways plasmas inactivate various pathogens. Focus is on the plasma effects on mammalian cells, subsequent consequences for cell-biological processes, and plasma applicability specific medical therapies.

Plasma medicine uses non-equilibrium plasmas generated under atmospheric-pressure conditions. Therapeutical plasmas can stimulate tissue regeneration or inactivate cancer cells. This book reviews the interrelation between plasma chemistry and biochemistry complemented by discussion of the ways plasmas inactivate various pathogens. Focus is on the plasma effects on mammalian cells, subsequent consequences for cell-biological processes, and plasma applicability specific medical therapies. Contributions illustrate the ways cold atmospheric-pressure plasma can be used as a controllable source of redox-active species and as a useful tool for research in redox biology.Key Features <ul> <li>Summarizes plasma chemistry, biochemistry, and microbiology </li> <li>Documents the ways plasmas interact with lipids, membranes, and cells </li> <li>Reviews therapeutic uses of plasmas in medicine </li> <li>Focuses on uses of plasmas as cancer treatment</li> </ul>

Redox Biology in Plasma Medicine

Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature controlling life at multiple levels.

Mitochondrial research has exploded over the last ~150 years. This book gives an amazing view on a conceptual change in our understanding of mitochondrial biology. It becomes clear that mitochondria are extremely dynamic in nature, controlling life at multiple levels. Mitochondria rule energy conversion, adapt cells well to changing stress and nutrient conditions, and regulate many cellular processes including immunity. The dynamic nature of mitochondria occurs at an intramitochondrial level but also includes its ability to interact with other organelles and to modulate multiple signalling pathways. It is thus not surprising that alterations or inabilities to ensure this dynamic behaviour is linked to ageing and human diseases.The following sections give an updated view on mitochondria:<ul> <li>Mitochondrial ultrastructure: molecular mechanisms shaping the inner membrane</li> <li>Mitochondrial cristae and lipid dynamics: from super-resolution microscopy to lipid-OXPHOS interplay</li> <li>Mitochondrial control of cellular homeostasis: from redox signalling to interorganellar contact sites</li> <li>Mitochondria in health and disease: from mtDNA release to Complex I assembly</li> <li>Advanced methods in mitochondrial biology and metabolism research</li> <li>Integrative view on mitochondrial research and outlook</li> </ul>The field of mitochondrial research has always been full of surprises and has helped science to advance tremendously. It developed hand in hand with landmark developments in technology, such as super-resolution microscopy (nanoscopy), and is currently influencing an increasing number of scientific disciplines. There is still much ‘new’ to find out about this ‘old’ organelle and I think that you can find interesting and also unexpected aspects of mitochondrial biology in this book. I hope the book will enhance your scientific curiosity and inspire your own research.

from Ultrastructure to Health and Disease

The Dynamic Nature of Mitochondria

Even before oxygen appeared in our athmosphere, redox reactions provided the energy for metabolic steps in the evolution of life. Redox modifications are now important in cellular functions including differentiation/development. This book compiles current knowledge regarding the roles of redox regulation in differentiation and de-differentiation.

Even before oxygen appeared in our athmosphere, redox reactions provided the energy for metabolic steps in the evolution of life. Redox modifications are now important in cellular functions including differentiation/development. This book compiles current knowledge regarding the roles of redox regulation in differentiation and de-differentiation.

Redox Regulation of Differentiation and De-differentiation

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Proteostasis and Proteolysis

Environmental risk factors - noise, air pollution, chemical agents, and ultraviolet radiation - impact human health by contributing to the onset and progression of non-communicable diseases.

Environmental risk factors – noise, air pollution, chemical agents, and ultraviolet radiation – impact human health by contributing to the onset and progression of non-communicable diseases.

Environmental Stressors and Oxinflammatory Tissues Responses

To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species.

To produce energy, aerobic organisms transform oxygen molecules into water. This reductive mechanism yields toxic radical intermediates, collectively known as reactive oxygen species (ROS). Paradoxically, these physiological processes entail the production of potentially damaging species.

Redox Signal Mediators In and Between Cells

Peroxiporins

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition. This is partially achieved by modulating several types of brain cell populations including those relevant to satiety and reward. Importantly, brains of Alzheimer¿s disease patients exhibit a signature of brain insulin resistance with perturbed brain metabolism. This book will cover the basics of insulin signaling in the brain and will describe concepts of insulin resistance, a feature of type 2 diabetes. Moreover insulin¿s effect on cognitive function will be pointed out and the association between brain insulin resistance and neurodegenerative diseases discussed. Additionally, potential behavioral and pharmacological concepts which can affect brain insulin signaling will be summarized.

Key Features:



Summarizes insulin and the closely related IGF-1 receptor signaling 





Depicts concepts of insulin resistance 





Highlights the importance of conserved brain insulin signaling for brain function, metabolism, and behavior





Describes potential behavioral and pharmacological approaches to support brain insulin signaling

The brain is crucial for the regulation of whole-body metabolism and behavior. The pancreas-derived hormone insulin modulates brain function and affects energy metabolism as well as cognition.

Physiological Consequences of Brain Insulin Action

Cell differentiation and the development of multicellular organisms are processes of self-assembly, controlled and driven by signaling molecules and cascades including redox regulation. These reactions may have provided the energy for the first metabolic steps in the evolution of life. Today, redox modifications are established as important regulatory events in cellular functions including differentiation and development. Redox modifications of single cysteines regulate differentiation of stem cells, formation of functioning organs, and de-differentiation such as formation of cancer cells. Current cancer therapy is based on redox events as well and regeneration often reactivates developmental pathways. Understanding differentiation and de-differentiation on a molecular level is therefore a prerequisite for the continuing development of new medical therapies. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. An international team of contributors presents several new aspects of redox-regulated differentiation and de-differentiation, including aspects of redox medicine.



Key Features



Provides the first summary on this important topic 





Reviews redox-dependent development of model organisms and single organs





Highlights the redox-regulated pathways important for differentiation processes





Illustrates the potential of redox medicine





Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration





Written by leading experts in the field







Related Titles

Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approaches to Cancer (ISBN 978-1-77188-067-1)

Clarke, M. &amp; J. Frampton. Stem Cells: Biology and Application (ISBN 9780-8153-4511-4)

Lim, W. &amp; B. Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1)

Wong, E., ed. Autophagy and Signaling (ISBN 978-0-367-65772-7)

High doses of vitamins have been used to treat cancer. This book explores the ways Vitamin C retards cancers through the perturbation of multiple cellular pathways, by eliciting a hypoxic response in cancer cells, by stimulation of radio-sensitivity, and by reprogramming somatic cell activities. A chapter summarizes clinical trials and therapies.

Vitamin C may offer significant therapeutic benefits in the treatment of cancer. This book includes chapters by a group of leading scientific researchers documenting the ways cancer can be affected by high doses of ascorbate. After an initial chapter providing a historical perspective, subsequent chapters focus on cancer cell death, reprogramming of somatic cells, recent case studies, and other ways vitamin C can improve outcomes of therapy. Features<ul> <li>Includes chapters from a team of leading international scholars</li> <li>Reviews the history of beneficial uses of vitamin C in the treatment of cancer</li> <li>Summarizes recent case studies</li> <li>Discusses how vitamin C may synergistically affect other cancer treatment methods</li> </ul>

Cancer and Vitamin C

A Pattern-Based Approach

Atlas of Neuropathology

A Computational Approach

Modeling Structure-Function Relations in Ion Channels

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

Sedimentation Equilibrium Analytical Ultracentrifugation

Immunological Insights and Emerging Therapeutics in Medical Mycology summarizes the current knowledge on interactions between host cells and human fungal pathogens and explains how certain immune defects lead to vulnerability to fungal infection. Chapters focus on immune response to such fungal infections as candidiasis, aspergillus, cryptococcosis, mucormycosis, pneumocystis.This title provides a basis for further study on antifungal immunity by enhancing understanding of antifungal immune responses. Further, this title offers new insights from the host immune response, improving understanding of disease pathogenesis and informing novel prophylactic and therapeutic approaches to fungal infections.

Immunological Insights and Emerging Therapeutics in Medical Mycology

Activate the Power of Your Gut to Tame Inflammation and Reclaim Your Health

Plant Powered Plus

Handbook of Clinical Neurology

Tic Disorders and Tourette Syndrome is an essential resource that delves into the clinical aspects, treatments, and ongoing research related to tic disorders and Tourette syndrome. It covers a range of topics from primary to secondary and functional tics, providing differential diagnosis. The book is designed to offer foundational knowledge to neurologists, psychiatrists, neuropsychiatrists, and psychologists, while also catering to the needs of advanced readers. In addition to clinical presentations, the book discusses the epidemiology, etiology, and pathophysiology of tics, along with common neuropsychiatric comorbidities such as obsessive-compulsive disorder, ADHD, mood disorders, and intermittent explosive disorder. The volume also includes treatment options and clinical scales to evaluate tics, illustrated with video accompaniments and animal models.

Tic Disorders and Tourette Syndrome

Series in Computational Biophysics

Multiscale methods are ideally suited to simulate the processes at work in many biomolecular systems, which often span a large range of time and length scales. Multiscale Methods in Molecular Biophysics highlights the advantages of these methods for integrating different levels of detail in a single simulation setting. It covers the practical methodology and successful applications in areas such as enzyme catalysis, protein folding, and ligand binding. The book is divided into three main sections: combination quantum and classical (atomistic) descriptions, approaches that combine atomistic and coarse-grained level of details, and multiscale methods where the resolution coupling is between global collective coordinates and local details.

Multiscale methods are ideally suited to simulate the processes at work in many biomolecular systems, which often span a large range of time and length scales. Multiscale Methods in Molecular Biophysics highlights the advantages of these methods for integrating different levels of detail in a single simulation setting. It covers the practical methodology and successful applications in areas such as enzyme catalysis, protein folding, and ligand binding. The book is divided into three main sections: combination quantum and classical (atomistic) descriptions, approaches that combine atomistic and coarse-grained level of details, and multiscale methods where the resolution coupling is between global collective coordinates and local details.

Multiscale Methods in Molecular Biophysics

Atlas of Dermatopathology

This book will not only deal with the analysis of nutraceuticals, but will also focus on the extraction and purification of the analytes using newer tools/instruments. It will also help the analyst during the actual estimation of these compounds from different matrices.

This book will not only deal with the analysis of nutraceuticals, but will also focus on the extraction and purification of the analytes using newer tools/instruments. It will also help the analyst during the actual estimation of these compounds from different matrices.

Practical Guide to LC Analysis of Nutraceuticals

Methods in Molecular and Materials Modelling

Methods in Biomolecular Modelling, Volume Two in the series, considers modeling methods with relevance to the study of biomolecular systems, including the workhorse of classical molecular dynamics and related techniques, areas where electronic structure methods find use, the higher length scales achievable through coarse grained and mesoscale methods, and combinations of scales. Applicability of methods is then illustrated with a wide range of biomolecular modeling research topics drawn from current research. Throughout the text, practical considerations of research are emphasized, including sourcing of structural data, scalability of methods on HPC systems, and linking of computation to experiment. Part I introduces a range of modeling techniques used for biomolecular simulation, explaining the fundamental principles of each and the research areas to which they are applicable. The strengths and weaknesses of each method are outlined, along with their real-world performance on current computing resources and future trends. Part II looks at a range of application areas, with case studies illustrating the methods that can be used to investigate biomolecular systems in these areas.

Methods in Biomolecular Modelling

Progress in Molecular Biology and Translational Science

Wearable, Ingestible and Implantable Technologies for Health and Wellness Monitoring Part B

Biosensing the Future: Volume 216

Mammalian Heme Peroxidases

Inhalt

Bibliografische Angaben

Inhaltsverzeichnis

Schlagworte

Inhalt

Bibliografische Angaben

Inhaltsverzeichnis

Schlagworte

Weitere Titel der Reihe: Oxidative Stress and Disease

Weitere Titel zum Thema