In this issue of Medical Clinics of North America, guest editors Drs. Moises Auron, Michelle Brooks, and Suchita Shah Sata bring their considerable expertise to the topic of Inpatient Quality Improvement and Patient Safety. Top experts address fundamental and current topics in quality of healthcare and patient safety in hospitalized patients, including discussions of the quality improvement process, high reliability organization, diagnostic errors, medication safety, and handoffs and care transitions, as well as clinical topics such as prevention of healthcare-acquired infections, pneumonia, heart failure, and more.