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Gesamtkatalog

Catalogue complet

Global Trends And Hotspots Of Kidney
Disease Research

Global Trends And Hotspots Of Kidney Disease Research

The Occasional Human Sacrifice is an intellectual inquiry into the moral struggle that whistleblowers face and why it is not the kind of struggle that most people imagine. For many years Carl Elliott fought for an external inquiry into a psychiatric research study at his own university in which an especially vulnerable patient lost his life. Elliott's efforts alienated friends and colleagues. The university stonewalled him and denied wrongdoing until a state investigation finally vindicated his claims. His experience frames the six stories in this book of medical research in which patients were deceived into participating in experimental programmes they did not understand, many of which had astonishing and well-concealed mortality rates. Elliott tells the extraordinary stories of insiders who spoke out against abuses and often paid a terrible price for doing the right thing.

Medical Experimentation and the Price of Saying No

The Occasional Human Sacrifice

Principles and Practice of Nephrocardiology

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

Structural Biology of Amyloid Fibrils

How do you count stem cells? This is a light, informative, and insider narrative of the discovery of the first method for routine, specific, and accurate quantification of therapeutic tissue stem cells. A technology sought after by the field of stem cell medicine for more than a century, James Sherley retraces his path toward the innovative breakthrough, weaving it with past and contemporaneous scientific history of relevant cancer and stem cell research. The story takes place within the larger context of scientific scholarship and research in powerful universities and institutes as an African American, offering an honest, if at times prickly, conversation about race and heritage in science. Written for both the novice and the expert, this book will intrigue readers with the nature of how new ideas are advanced in science and medicine and inform them of the fundamentals of scientific investigation and stem cell medicine, all provided in an accessible and entertaining form.

Counting Stem Cells: A Story Of Not Counting

Systematic Data Collection

Meta-analysis Using R

Sources of Strength and Wisdom

Making a Good Doctor

New Directions in Organic & Biological Chemistry

This latest volume in the New Directions in Organic &amp; Biological Chemistry series provides a comprehensive overview of quinoline derivatives, focusing on their chemical structure, biological activities, and therapeutic benefits. It delves into the natural sources of these derivatives, covering their isolation, characterization, and potential therapeutic applications, particularly in areas such as anti-cancer, anti-inflammatory, antimicrobial, and antimalarial activity. With its emphasis on providing valuable reference material, this book is an indispensable resource for researchers, educators, and professionals in the fields of chemistry, biology, pharmacology, and drug discovery.

Natural Occurrence and Biological Activities of Quinoline Derivatives

Advances in Magnetic Resonance Technology and Applications

Advanced MR Techniques for Neurodegenerative Diseases covers state of the art developments in physiologic, metabolic, functional, and microstructural MRI of the brain. It provides an overview of these approaches and includes dynamic contrast enhanced (DCE) MRI, dynamic susceptibility contrast (DSC) MRI, arterial spin labeling (ASL), chemical exchange saturation transfer (CEST) MRI, magnetic resonance spectroscopy (MRS), resting state functional MRI (rsfMRI), microscopic diffusion imaging, and quantitative susceptibility mapping (QSM). Chapters then follow that present the application of these methods to Alzheimer’s Disease and vascular dementia, small vessel disease, Parkinson’s Disease, Lewy body dementia, Huntington’s Disease, Amyotrophic Lateral Sclerosis, and Multiple Sclerosis. Advanced MR Techniques for Neurodegenerative Diseases is a comprehensive resource on the latest advanced MR techniques and their application to neurodegenerative diseases, suitable for MR engineers and physicists as well as clinicians and neuroscientists who use MR techniques for diagnosis and research.

Advanced MR Techniques for Neurodegenerative Diseases: Volume 13

Understanding Pain

Chronic

Chromatographic Science Series

Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

Chirality plays a major role in biological processes and the enantiomers of a bioactive molecule often possess different biological effects. Accurate assessment is critical as isomeric impurities may have unwanted toxicological, pharmacological, or other effects. Separation techniques remain the method of choice for this area of drug research but there is a great deal of trial and error in choosing a particular column for a chiral separation. This book gives a rationale for choosing a stationary phase that is based on the relationship that exists between the analytes and the chiral stationary phases. The text provides examples to underline the separation mechanism.

Chiral Recognition and Separation Mechanisms

The transformative role of artificial intelligence (AI) in modern biomanufacturing focuses on key areas such as process analytical technology (PAT), Good Manufacturing Practice (GMP) compliance, predictive analytics, and AI-driven quality systems. It bridges cutting-edge AI applications with the complexities of biotherapeutic production, offering insights into automation, real-time monitoring, and process optimization.Delving into the core of biomanufacturing, the book provides a structured journey through its critical phases. It begins with an introduction to modern biomanufacturing principles, quality by design approaches, and the integration of AI. Subsequent chapters examine raw material management, lean manufacturing practices, and the application of predictive analytics to optimize supply chains. Readers will explore advanced tools such as AI-enhanced data acquisition in PAT, automated standard operating procedures (SOPs), and AI-driven process controls for fermenters and chromatography systems. The text also addresses GMP essentials, including personnel management, hygienic facility design, and pharmaceutical water systems. Key chapters highlight AI's role in validation processes, sterile packaging, and regulatory compliance, referencing global guidelines from organizations such as the WHO, FDA, and ICH. Real-world case studies featuring therapeutic proteins, monoclonal antibodies, and vaccines underscore the practical applications of AI in scaling and maintaining biotherapeutic production.This book equips readers with a comprehensive understanding of AI's potential to enhance efficiency, accuracy, and compliance in biomanufacturing. Whether you are a professional, researcher, or student, this guide offers actionable insights into leveraging AI to revolutionize biotherapeutic production while adhering to the highest industry standards.What You Will Learn:<ul> <li>Understand how AI enhances every phase of biotherapeutic production, from raw material management to regulatory compliance, optimizing efficiency, accuracy, and quality</li> <li>Explore the role of AI in advanced data acquisition, process control, and continuous improvement, including applications in fermenters, flow filtration, and chromatography systems</li> <li>Gain insights into leveraging AI for automating standard operating procedures (SOPs), predictive maintenance, quality assurance, and adhering to global GMP standards like WHO and FDA guidelines</li> <li>Learn how AI transforms upstream and downstream processes, ensures sterility in packaging, and supports case studies on therapeutic proteins, monoclonal antibodies, and human vaccines</li> <li>Discover the potential of AI in shaping the future of biomanufacturing, including challenges, data security, and the ethical implications of AI-driven automation</li> </ul>

Principles, Practices, and Standards

Artificial Intelligence in the Production of Biotherapeutics

Global Trends And Hotspots Of Kidney Disease Research

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