On What Evidence? presents a case-based approach to clinical decision-making that integrates many kinds of medical knowledge in providing care for an individual patient. Since the rise in popularity of evidence-based medicine (EBM), most discussions of medical decision-making have focused almost entirely on knowledge derived from clinical research. Robyn Bluhm and Mark Tonelli evaluate other sources of knowledge--laboratory research on physiological mechanisms, a physician's own clinical experience, and a patient's experiences and values--to demonstrate that these are equally important in making decisions about care.