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Methods in Enzymology

Bacterial Efflux Systems: Volume 722

Transketolases: Volume 724

Artificial Metalloproteins: Volume 723

Cyclic Peptides: Volume 721

Enzyme Reprogramming: Volume 719

Protein Termini: Volume 718

Genomics-Guided Natural Products Discovery: Volume 717

Lignin-Degrading Enzymes: Volume 716

Enzymes of Polyamine Metabolism: Volume 715

Apobec Enzymes: Volume 713

TRNA-derived RNAs: Volume 711

CRISPR-Cas Systems for RNA and Genome Editing: Volume 712

Biocatalysis: Volume 714

"Although monoclonal antibodies comprise the largest share of approved therapeutic molecules, many new non-antibody modalities are being evaluated in the clinic. These new biologics are more complex, which comes as a result of a greater understanding of underlying disease biology as well as advanced engineering approaches. All recombinant proteins made for both research purposes and as therapeutic moieties undergo in depth analytical characterization using a variety of tools including mass spectrometry. As molecules increase in their complexity, the analytical field has had to keep up with improvements in the high-throughput, complexity, and sensitivity of characterization techniques"-- Provided by publisher.

Analytical Methods for Diverse Modalities

Characterizing Biotherapeutics

Plant Biology, sustainability and climate change

Radiation Spectrum and Plant Metabolism: Interaction from the Sub-cellular to Ecosystem Level offers a clear illustration of the interaction between radiation spectrums and the dynamics of biological systems in plants. Explaining the light-Phyllosphere relationship, this volume describes metabolite chemistry, thus reflecting the developmental and functional fitness of the plant. As climate change has resulted in a natural variation in the cosmic radiation spectrum, a knowledge gap has emerged about the changing radiation spectrum and its impacts on plant metabolism. This book addresses the subject in-depth, providing insights into the functional role of photoreceptors, pigments, and various metabolites in coping with this alteration. It will be a valuable reference for photo biologists, biophysicists, and biochemists for deciphering the impacts of radiation spectrum on plant metabolism. Researchers working in the field of metabolite chemistry and metabolomics will also find it useful to comprehend the physical laws governing the interaction of radiation spectrum with biological system.

Interaction of Radiation Spectrum with Sub Cellular Ecosystem Level

Radiation Spectrum and Plant Metabolism

Methods in Molecular and Materials Modelling

Methods in Biomolecular Modelling, Volume Two in the series, considers modeling methods with relevance to the study of biomolecular systems, including the workhorse of classical molecular dynamics and related techniques, areas where electronic structure methods find use, the higher length scales achievable through coarse grained and mesoscale methods, and combinations of scales. Applicability of methods is then illustrated with a wide range of biomolecular modeling research topics drawn from current research. Throughout the text, practical considerations of research are emphasized, including sourcing of structural data, scalability of methods on HPC systems, and linking of computation to experiment. Part I introduces a range of modeling techniques used for biomolecular simulation, explaining the fundamental principles of each and the research areas to which they are applicable. The strengths and weaknesses of each method are outlined, along with their real-world performance on current computing resources and future trends. Part II looks at a range of application areas, with case studies illustrating the methods that can be used to investigate biomolecular systems in these areas.

Methods in Biomolecular Modelling

Ecology & Applications

Marine Microbiology

Matters of the Image introduces a new framework for thinking about digital images.

Designing Digital Images with Materiality, Energy, and Living Matter

This book reviews the epidemiology, etiology, ongoing clinical trials, emerging personalized therapies, advanced drug delivery systems, and pathophysiology of Chronic Obstructive Pulmonary Disease (COPD). It serves as a valuable resource for professionals, scientists, academicians, and clinicians specializing in respiratory health.

Advanced Drug Delivery Systems in Management of Chronic Obstructive Pulmonary Disease

A follow-up to the experimental and instrumental aspects described in Basic Principles of Analytical Ultracentrifugation, the volume Sedimentation Velocity Analytical Ultracentrifugation: Discrete Species and Size-Distributions of Macromolecules and Particles describes the theory and practice of data analysis. Mathematical models for the sedimentation process and the evolution of detected signals are developed in a comprehensive framework, jointly with the description of current and historical strategies for how to extract from noisy experimental data the physical parameters of interest, such as size, mass, and shape, composition, and polydispersity of sedimenting particles. The methods are extensively illustrated, and supported with practical applications, as well as cross-references where to find the methods in the public domain software SEDFIT and SEDPHAT. The systems covered are discrete or polydisperse mixtures of sedimenting molecules or particles in dilute solution, such as proteins and other biomolecules and their stable complexes, man-made polymers, and nanoparticles, observed in different optical systems. These methods form the essential foundation for the analysis of dynamic interacting systems, which are covered in a separate volume.

Sedimentation Equilibrium Analytical Ultracentrifugation

This book describes the risks of working with dangerous pathogens and toxins in the current era of international terrorism. The authors characterize the global spread of legitimate biotechnology and relate it to the rise of transnational terrorism, emphasizing the need for biosecurity measures even in legitimate bioscience. This second edition is considerably longer than the first and includes several new chapters and sections, with the final two-thirds of the book entirely reorganized.

Laboratory Biosecurity Handbook, Second Edition

Series in Computational Physics

This book provides an in-depth introduction to molecular dynamics (MD) simulation, the basis for computational study of complex atomic and molecular systems. The author clarifies the role of different variables and sequences throughout, avoids excessive mathematical detail, emphasizes graphical representations, and highlights illustrative applications in materials science, biology, and biochemistry. The text also presents tips for speeding up calculations and parallelization techniques based on OpenMP. The final section offers hands-on training to open-source MD codes (NAMD) and associated post-processing.

A Practical Guide Using C/C++, FORTRAN, and Python

Introduction to Molecular Dynamics Simulations

The proposed book will compile the recent development and the updated overview about the Aflatoxigenic fungi and its impact on plant, animal and human health including various agricultural soil, food crops and advanced methods involved in the detection of Aflatoxigenic fungi.

Its Impact on Plant, Animal and Human Health

Aflatoxigenic Fungi

Disease Mechanism, Therapy, and Drug Resistance

Blood-infecting Protozoal Diseases

Bacterial Efflux Systems: Volume 722

Informations bibliographiques

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Informations bibliographiques

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