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Bacterial Biofilm and Chronic Infections

Role in Disease Pathogenesis and Therapeutic Strategies 

Woodhead Publishing Series in Biomaterials

Engineered Biomaterials for Drug Delivery covers a core selection of engineering approaches and methods to optimize materials for drug delivery, including grafting, cross-linking, thiolation, conjugation, and the functionalization of biomaterials. A wide range of engineered biomaterial types are described, from biopolymers and nanobiomaterials, to metals, ceramics, and composites. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

Engineered Biomaterials for Drug Delivery

Drug Discovery Opinions

Antimicrobial Therapeutics and Drug Discovery

This book discusses current concepts and practice on analytical approaches for characterization of medicinal plants and plant-based products. It reviews all aspects of extraction, spectroscopic analysis, isolation, chemometrics, DNA bar-coding, in-line processing, and bioassays.

Analytical Techniques for Quality Control of Medicinal Plants

Chemical Receptor Sensory Systems explores chemosenses through the lens of pharmacologic theory, and how chemosensory systems, from the molecular level to the behavior of organisms, must behave given that their operations are functions of receptor pharmacodynamics and pharmacokinetics. Throughout the book, information on concentration-dependence of chemical stimulation and likely relationship to receptor occupancy is strongly emphasized. In cases where a departure from expected pharmacologic behavior is encountered in the chemosenses, the discussion is directed toward probable explanations for the apparent disconnect. This book provides a new resource that on all chemosenses topics within a unifying conceptual framework of the science of pharmacology. It will be useful to a variety of researchers and graduate students in pharmacology, biology and physiology of sensory systems, researchers in sensory psychology, research scientists in food &amp; nutritional scientists, as well as clinical staff.

Chemical Receptor Sensory Systems

Basic Neurochemistry: Principles of Molecular, Cellular, and Medical Neurobiology, Ninth Edition is a classic advanced neurochemistry and neurobiology textbook that has a renewed focus on clinical applications. The early chapters focus on fundamental membrane chemistry, cellular signaling, and development of the nervous system. Later chapters cover cell injury and inflammation, neurodegenerative diseases, sensory transduction, and neural processing/behavior. By understanding mechanisms at the molecular and systems level, scientists can develop new pharmacotherapies to treat diseases such as Alzheimer's Disease, Parkinson's Disease, Multiple Sclerosis as well as neuropsychiatric diseases (e.g., schizophrenia, depression, pain, addictions). This book provides a foundation of all key principles of neurochemistry and neurobiology--within the context of human diseases--for advanced students and graduate students in neuroscience, biomedical sciences, as well as clinical neuroscientists and neurologists.

Principles of Molecular, Cellular, and Medical Neurobiology

Basic Neurochemistry

AI-Powered Drug Delivery to Neuro and Cardiovascular Systems: Perspectives and Future Challenges is a comprehensive reference covering the transformative potential of Artificial Intelligence (AI) in the realms of neuro and cardiovascular drug delivery. Designed to integrate and review the latest literature, this book provides an in-depth understanding of how AI is set to revolutionize clinical practices, protocols, and regulatory guidelines in therapeutic drug delivery. As AI and robotics continue to evolve, their role in enhancing precision, personalization, and efficiency in cardiovascular and neurological drug delivery becomes increasingly essential. The book opens with an introduction to the foundational concepts of AI in drug delivery, followed by a detailed examination of current AI practices in managing cardiovascular and neurological diseases. It progresses to explore AI-enhanced drug design and testing for cardiovascular conditions, and the application of AI in cardiac drug delivery vehicles. Insights into bioengineered heart and vessels, AI-inspired redox homeostasis, and targeted drug replenishment in cardiac matrix remodeling are thoroughly discussed. The text also covers novel avenues in mitochondrial drug retention, AI-assisted pharmaco and gene therapy for neurodegenerative diseases, and the role of AI in heart health. Further sections address the augmented optimization of medical side effects, neuromodulation with pharmacotherapy from an AI perspective, and smart systems for managing cerebrovascular accidents. The book concludes with a discussion on translational challenges and future directions in the field. This book is an invaluable resource for healthcare professionals, researchers, and students keen on understanding the dynamic interplay between AI and drug delivery systems. By offering insights into AI-driven prediction models, personalized drug regimens, and advanced robotic delivery mechanisms, it sets the stage for the next generation of cardiovascular and neurotherapeutic management. The perspectives, concepts, and innovations discussed are integral to shaping the future of cardiovascular and neurological healthcare.

Perspectives and Future Challenges

AI Powered Drug delivery to Neuro and Cardiovascular Systems

Chromatographic Science Series

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Analytical Aspects of Bioequivalence

Clinical Pharmacy and Therapeutics

Palgrave Studies in Medieval and Early Modern Medicine

Surviving the demise of his humoral pathology and anatomy, Galen’s works on simple and compound remedies (the so-called ‘galenicals’) formed the backbone of Western pharmacology up until the Industrial Revolution. Over its long and multicultural tradition—spanning the Roman Empire and Byzantium, through Islamicate societies, India, and China, to the New World and even Japan—Galenic pharmacopoeia evolved to incorporate new remedies, foods, philosophical rationales, and modes of preparation, including chemical ones. Despite its endurance, a systematic exploration of the use of galenicals beyond the Renaissance remains overdue.
Addressing this gap, the contributions in this volume bring together leading scholars who illuminate how this medical tradition unfolded in the early modern period and its underlying dynamics, often drawing on new or overlooked archival material. Challenging the prevailing narrative of decline, they examine how pharmacological knowledge was transmitted across languages and medical traditions. Each contribution highlights an aspect of the various conceptual adaptations this process entailed, including textual transmission, debates over the structure of matter, occult qualities, dosage quantification, apothecary regulations, patient treatment, and the integration of galenicals into household medicine. Special attention is also given to the commodification of materia medica in Atlantic trade, while a comprehensive introduction contextualises the main themes of Galen’s post-Renaissance legacy and explores the reasons for its enduring vitality.
Chapter 13 is available open access under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License via link.springer.com.

Traditions, Theories, Transformations, and Trades (1400-1750)

Galen's Remedies in the Early Modern Period

Dieses Fachbuch bietet eine vollständige und detaillierte Darstellung aller wichtigen Medikamente und Wirkstoffe zur intravitrealen Applikation in der Ophthalmologie. Dabei wird unter anderem auf VEGF-Inhibitoren, Corticosteroide und Antibiotika eingegangen. Eine übersichtliche Präsentation in alphabetischer Auflistung – von A bis Z – macht die verschiedenen Wirkstoffe schnell auffindbar. So können Indikationen, Dosierungen oder pharmakologische Eigenschaften rasch nachgeschlagen werden. Hintergrundinformationen zu Handelsnamen, Biosimilars und Zulassungsdetails zur intravitrealen Therapie helfen zudem, den Überblick über die verfügbaren Wirkstoffe zu behalten. Systematische Übersichtstabellen am Ende des Buches strukturieren die Medikamente nach chemischer Eigenschaft, Indikation oder Wirkweise.Ein detaillierter Leitfaden mit fundiertem Wissen über die intravitrealen Medikamente und ihre Anwendung.Über den Autor:Prof. Dr. med. Antonio Bergua, FEBO, ist Oberarzt an der Augenklinik des Uniklinikums Erlangen und verantwortlich für die Uveitis-Sprechstunde sowie für den Bereich Lid-, Tränenweg- und Orbita-Chirurgie. Er hat langjährige Erfahrung in der Indikationsstellung und Anwendung intravitrealer Medikamente. Bereits 2017 veröffentlichte er das Buch „Das menschliche Auge in Zahlen“, ebenfalls beim Springer-Verlag.

Von A bis Z

Intravitreale Medikamente

Advances in Anatomy, Embryology and Cell Biology

This book reviews the role of exosomes in both male and female reproduction organs, focusing on the impact of extracellular vesicles on gamete maturation and embryo development.
Fertilization is a complex process involving the fusion of two functionally matured gametes. Maturation of spermatozoa and/ or oocyte dependents on sophisticated, but highly regulated events during gamete transit in the reproductive tracts. Sperm maturation occurs within the epididymis, of which segmented regions provide a distinct microenvironment to facilitate stage-wise maturation processes. Although oocyte maturation occurs within the ovary, communication between oocyte and its surrounding granulosa/cumulus cells is vital for the development and the resumption of meiotically arrested oocytes. Once the oocyte is released from the ovary, the oviductal epithelium continues to facilitate sperm-oocyte interaction to achieve fertilization. Increasing evidence suggests that the uterus, the site for embryo development, also carries out epithelia- embryo communication via uterosomes throughout the pregnancy. All above-mentioned processes rely on orchestrated communications between reproductive tract epithelia and gametes.
In this book, we aim to summarize the origin of secretory vesicles from the reproductive tract and their functions for gamete and embryo development. It is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in extracellular vesicles research.

Origin, Functions and Perspective

Extracellular Vesicles in Reproduction

Pharmacy Education Series

The new edition of a bestseller, this book covers the principles of chemistry and biology necessary to understand drug action at the cellular level. The book places special emphasis on the chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, drug metabolism and elimination, and the genetic basis for variations in drug response. The book includes revision and updates of chapters. It also includes new material on pharmacogenomics, cancer chemotherapies, and drug-receptor and drug-enzyme interactions.

Understanding Drug Actions and Reactions, Second Edition

Basic Pharmacology

Bacterial Biofilm and Chronic Infections

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