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Translational and Applied Genomics

Economic Evaluation in Genomic and Precision Medicine provides an in-depth examination of essential concepts, protocols and applications of economic evaluation in genomic and precision medicine. Contributions from leading international medical geneticists and health economists compile new ways to effectively assess the costs and outcomes of different genomic care pathways, implement cost-effective medical interventions, and enhance the value of genomic and precision healthcare. Foundational chapters and discipline-specific case studies cover topics ranging from the economic analysis of genomic trial design, to health technology assessment of next-generation sequencing, ethical aspects, economic policy in genomic medicine, and pricing and reimbursement in clinical genomics.

Economic Evaluation in Genomic and
Precision Medicine

Economic Evaluation in Genomic and Precision Medicine

1. Introduction to economic evaluation in health sciences 2. Foundations of pharmacogenomics and personalized medicine 3. Economic evaluation of genome-guided treatment in oncology 4. Economic evaluation of rare diseases and the diagnostic odyssey 5. Economic analysis of pharmacogenetic testing for HLA-based adverse drug reactions 6. Economic evaluation of personalized medicine interventions in medium- and low-income countries with poor proliferation of genomics and genetic testing 7. Theoretical models for economic evaluation in genomic and personalized medicine 8. Using big data in economic evaluations in genomics: Challenges and opportunities 9. Assessing the stakeholder environment and views towards implementation of personalized medicine in a healthcare setting 10. Feasibility for pricing, budget allocation, and reimbursement of personalized medicine interventions

Raising Genomics Literacy, Knowledge, and Awareness is a unique resource which describes the importance of genomic literacy for the effective and streamlined implementation of genomic medicine and pharmacogenomics globally. It provides evidence and expert opinion to decipher the role of genomic and pharmacogenomic literacy to illustrate the evidence, value, and need of raising genomics awareness and education among healthcare professionals, students, and the general public. This text can be used by researchers and graduate students pursuing research in this area.

Raising Genomics Literacy, Knowledge, and Awareness

Population Genomics in the Developing World: Concepts, Applications, and Challenges, a new volume in the Translational and Applied Genomics series, provides a comprehensive, up-to-date summary of the field of population genomics in developing countries. The book equips students, researchers, and clinicians with the practical skills and approaches necessary to face the unique challenges and opportunities of practicing population genomics in developing countries. Following a brief foundational overview, more than a dozen authors working in developing nations share applied case studies from the field, including rationale, methods, analysis, and outcomes to reinforce understanding. Key themes across the country specific chapters include efficient genetic data generation and effective computational and statistical tools to analyze population-level data. The book then discusses clinical interpretation of this data, from direct-to-consumer ancestry testing to translational and applied precision medicine. A final chapter considers ethical aspects of conducting genomic research in developing countries.

Concepts, Applications, and Challenges

Population Genomics in the Developing World

Rigor and Reproducibility in Genetics and Genomics: Peer-reviewed, Published, Cited provides a full methodological and statistical overview for researchers, clinicians, students, and post-doctoral fellows conducting genetic and genomic research. Here, active geneticists, clinicians, and bioinformaticists offer practical solutions for a variety of challenges associated with several modern approaches in genetics and genomics, including genotyping, gene expression analysis, epigenetic analysis, GWAS, EWAS, genomic sequencing, and gene editing. Emphasis is placed on rigor and reproducibility throughout, with each section containing laboratory case-studies and classroom activities covering step-by-step protocols, best practices, and common pitfalls. Specific genetic and genomic technologies discussed include microarray analysis, DNA-seq, RNA-seq, Chip-Seq, methyl-seq, CRISPR gene editing, and CRISPR-based genetic analysis. Training exercises, supporting data, and in-depth discussions of rigor, reproducibility, and ethics in research together deliver a solid foundation in research standards for the next generation of genetic and genomic scientists.

Peer-reviewed, Published, Cited

Rigor and Reproducibility in Genetics and Genomics

Genomics and the Global Bioeconomy, a new volume in the Translational and Applied Genomics series, empowers researchers, administrators, and sustainability leaders to apply genomics and novel omics technologies to advance the global bioeconomy and sustainability. Here, more than 15 international experts illustrate--with concrete examples across various industries and areas of global need--how genomics is addressing some of the most pressing global challenges of our time. Chapters offer an in-depth, case-based treatment of various topics, from genomics technologies supporting sustainability development goals to novel synthetic biology advancements improving biofuel production, conservation, sustainable food production, bioremediation, and genomic monitoring. Editors Catalina Lopez-Correa and Adrian Suarez-Gonzalez skillfully bring clarity to this diverse and increasingly impactful research, uniting various perspectives to inspire fresh innovation in driving the global bioeconomy. -- Provided by publisher.

Genomics and the Global Bioeconomy

**Selected for Doody’s Core Titles® 2024 in Clinical Genetics** Psychiatric Genomics presents and synthesizes available knowledge in the field of psychiatric genomics, offering methodologies to advance new research and aid clinical translation. After providing an introduction to genomics and psychiatry, international experts discuss the genomic basis of schizophrenia, bipolar disorder, depression, personality disorders, anxiety disorders, addictions, eating disorders, and sleep disorders, among other disorders. In addition, recommendations for next steps in clinical implementation and drug discovery are discussed in-depth, with chapters dedicated to pharmacogenomics and antipsychotics, antidepressants and mood stabilizers, adverse drug reactions, implementation of pharmacogenomics in psychiatric clinics, and ethical issues. Finally, methods sections provide a solid grounding in research approaches and computational analytics, from using animal models in psychiatric genomics and accessing biobanks, to employing computational analysis, genome-wide association studies (GWAS), brain pathophysiology, and endophenotypes in psychiatric research.

Psychiatric Genomics

Genomics in Biosecurity: Principles and Applications of Genomic Technologies in Expanded Biosecurity Concepts, in the Translational and Applied Genomics series, explains in definite and practical terms the applicability of genomic technologies in every aspect of biosecurity, from emergent diagnostics to bioterrorism, agroterrorism, next generation biowarfare, biosurveillance and risk assessment. This book offers an integrated discussion of genomics and GCBR (global catastrophic biological risks) events, considering both basic aspects of biosecurity genomics and application of genomic technologies to drive new solutions. Readers will find evidence-based strategies to apply genomics in disease and pathogen monitoring and diagnosis, and more. Social aspects of GCBR events and genomic biosecurity, such as issues of terrorism, policy ethics, and practice, are also considered in-depth.

Principles and Applications of Genomic Technologies in Expanded Biosecurity Concepts

Genomics in Biosecurity

"Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism"--

Understanding Disease Genetics Using Genomic Approaches

Genomics of Rare Diseases

Clinical DNA Variant Interpretation: Theory and Practice, a new volume in the Translational and Applied Genomics series, covers foundational aspects, modes of analysis, technology, disease and disorder specific case studies, and clinical integration. This book provides a deep theoretical background, as well as applied case studies and methodology, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes. Practical chapters discuss genomic variant interpretation, terminology and nomenclature, international consensus guidelines, population allele frequency, functional evidence transcripts for RNA, proteins, and enzymes, somatic mutations, somatic profiling, and much more.

Theory and Practice

Clinical DNA Variant Interpretation

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery.

Genome Plasticity in Health and Disease

Secondary Findings in Genomic Research offers a single, highly accessible resource on interpreting, managing and disclosing secondary findings in genomic research. With chapters written by experts in the field, this book is the first to concisely explain the ethical and practical issues raised by secondary genomics findings for a multi and interdisciplinary audience of genomic researchers, translational scientists, clinicians, medical students, genetic counselors, ethicists, legal experts and law students, public policy specialists and regulators. Contributors from Europe, North America, and Asia effectively synthesize perspectives from a spectrum of different scientific, societal, and global contexts, and offer pragmatic approaches to a range of topics, including oversight, governance and policy surrounding secondary genomic results, criteria for identifying results for return, communication and consent, stakeholders' attitudes and perspectives, disclosing results, and clinical, patient-centered protocols.

Secondary Findings in Genomic Research

Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth.

Cellular and Animal Models in Human Genomics Research

Human Genome Informatics: Translating Genes into Health examines the most recent and commonly used electronic tools to translate genomic information into a clinically meaningful format. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases and how to rationalize drug use are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics; it is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field.

Translating Genes Into Health

Human Genome Informatics

Biofeedback and Pain Management: A Clinical Guide is a practical and informative reference to help readers have a better understanding of the psychophysiology of chronic pain, biofeedback treatments, realities of living life with chronic limitations related to pain, and the role of pain in our lives and society. The book aims to organize available evidence on effective uses of biofeedback interventions for pain management, including protocols, as well as case-based examples and strategies that practitioners can refer to in real-life settings. Biofeedback and Pain Management is organized into three sections. In the first section, "Psychophysiology of Pain," a clear treatment rationale for the use of biofeedback is illustrated, including patient-friendly language about what is biofeedback and illustrations depicting how biofeedback is a useful part of any pain management treatment plan. In the next section, "Biofeedback Protocols," procedures are detailed based on evidence as well as case-based examples. This section is the heart of the book and offers essential strategies that readers can refer to on an as-needed basis. The final section, "Community Pain," explores the larger social context of chronic pain, the toll it has on public health and the ongoing role of healthcare providers who witness pain-related suffering.

A Clinical Guide

Biofeedback and Pain Management

Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

Fluid Dynamics of Viral Transmission

Kunterbunter Faltspaß für KinderDieses Buch steckt voller bunter Frühlingsmotive. Mit&nbsp;über 100&nbsp;zauberhaften Motivpapieren&nbsp;und&nbsp;einfachen Schritt-für-Schritt-Anleitungen&nbsp;entstehen kinderleicht tolle Origamifiguren.<ul><li>Über 100 Origamipapiere:&nbsp;Abwechslungsreiche Motive&nbsp;zum einfachen Heraustrennen</li><li>Einfach nachzufalten:Schritt für Schritt mit vielen Bildern</li><li>Fantastische Figuren: Abwechslungsreiche Faltkunstwerke zum Aufstellen und Verschenken</li><li>Ideal als Geschenk:&nbsp;Ob als Mitbringsel oder für das Osternest für kreative Kids</li></ul>Das Rundumsorglos-PaketMit dem beiliegenden Material können die Kinder sofort loslegen. Ob Schmetterling, Herz oder Vogel, Falten macht Spaß und trainiert spielerisch die Feinmotorik. Für Kinder&nbsp;ab 7 Jahren&nbsp;

Kunterbunter Faltspaß für KinderDieses Buch steckt voller bunter Frühlingsmotive. Mit&nbsp;über 100&nbsp;zauberhaften Motivpapieren&nbsp;und&nbsp;einfachen Schritt-für-Schritt-Anleitungen&nbsp;entstehen kinderleicht tolle Origamifiguren.<ul><li>Über 100 Origamipapiere:&nbsp;Abwechslungsreiche Motive&nbsp;zum einfachen Heraustrennen</li><li>Einfach nachzufalten: Schritt für Schritt mit vielen Bildern</li><li>Fantastische Figuren: Abwechslungsreiche Faltkunstwerke zum Aufstellen und Verschenken</li><li>Ideal als Geschenk:&nbsp;Ob als Mitbringsel oder für das Osternest für kreative Kids</li></ul>Das Rundumsorglos-Paket Mit dem beiliegenden Material können die Kinder sofort loslegen. Ob Schmetterling, Herz oder Vogel, Falten macht Spaß und trainiert spielerisch die Feinmotorik. Für Kinder&nbsp;ab 7 Jahren&nbsp;

Mit über 100 Papiervorlagen

Frühlings-Origami

How One Ancient Language Went Global

Proto

Operative Strategies in Pelvic Exenteration Surgery is a reference for the surgical management of Pelvic Exenteration Surgery. It covers all aspects of surgery from the colorectal, urological, gynecological, and orthopedic point of view. Coverage consolidates the research of world-leaders and includes the history of exenterative study, outlining the current state and indicating future developments. The book also discusses the current surgical operative strategies for the management of locally advanced and recurrent pelvic neoplasms with illustrations, intra-op photos, and supplementary video material. Created from the experiences of an international collaboration of surgeons, this reference is the perfect reference for surgical oncologists, colorectal, gynecology, urology, and vascular surgeons as well as any group involved in complex pelvic surgery including complex open, laparoscopic, and robotic surgery.

Operative Strategies in Pelvic Exenteration Surgery

How New Technologies and Old Myths Are Shaping Our Genomic Future

What We Inherit

This book highlights the efficacy of molecular data in inferring phylogeny. References throughout the book illuminate the taxonomic terminology and literature. The book includes a range of topics beginning from gene to phylogenomics and provides an up-to-date information about plant molecular systematics.

This book highlights the efficacy of molecular data in inferring phylogeny. References throughout the book illuminate the taxonomic terminology and literature. The book includes a range of topics beginning from gene to phylogenomics and provides an up-to-date information about plant molecular systematics.

Plant Molecular Systematics

Aortic Valve Repair provides a comprehensive summary on techniques developed during the first 500 cases of aortic ring annuloplasty. Aortic valve disease is usually surgically managed by aortic valve replacement, and it is well established in published literature regarding the long-term results, survival rate, durability of the protheses and reoperations rates. Over the past two decades, aortic valve repair (AVr) has evolved into a recognized surgical option for selected patients with aortic insufficiency or proximal aorta aneurysm. Studying the first 500 cases of aortic ring annuloplasty, the authors provide the most effective methods of leaflet and aortic root reconstruction to repair pathologies. Including original illustrations and videos, the book serves as an essential reference for cardiac surgeons in practice.

Aortic Valve Repair

Genetics and Society

This book provides a timely analysis of the past, present and future of the stem cell. It uncovers an intriguing and paradoxical story of scientific setbacks and advance, medical breakthroughs and technical innovation amid ongoing uncertainty about the nature of the stem cell.

This book provides a timely analysis of the past, present and future of the stem cell. It uncovers an intriguing and paradoxical story of scientific setbacks and advance, medical breakthroughs and technical innovation amid ongoing uncertainty about the nature of the stem cell.

From Radiobiology to Regenerative Medicine

The Scientific, Clinical and Commercial Development of the Stem Cell

Primarily meant for undergraduate and graduate students wanting to develop their expertise in agricultural sceince and chemistry, this book aims at understanding the basic physical chemistry of soils. In addition, environmental problems such as soil stresses and the interactions between the different environmental components are highlighted. This book serves as a basic tool for students enrolled in agriculture, soil science and environmental science courses.

Primarily meant for undergraduate and graduate students wanting to develop their expertise in agricultural sceince and chemistry, this book aims at understanding the basic physical chemistry of soils. In addition, environmental problems such as soil stresses and the interactions between the different environmental components are highlighted. This book serves as a basic tool for students enrolled in agriculture, soil science and environmental science courses.

Physical Chemistry of Soils

The dinosaur-bird transition has been intensively studied using both fossil and embryological evidence. In recent years, the notion that birds are living dinosaurs has become the mainstream opinion in paleontology. But some embryologists and ornithologists remain skeptical and accuse paleontologists of ignoring conflicting evidence. This book resolves these conflicts. Careful re-evaluation of those features in seeming contradiction reveal that such characteristics actually support and corroborate the mainstream view that birds are in fact members of a dinosaurian lineage - they are living dinosaurs.

The dinosaur-bird transition has been intensively studied using both fossil and embryological evidence. In recent years, the notion that birds are living dinosaurs has become the mainstream opinion in paleontology. But some embryologists and ornithologists remain skeptical and accuse paleontologists of ignoring conflicting evidence. This book resolves these conflicts. Careful re-evaluation of those features in seeming contradiction reveal that such characteristics actually support and corroborate the mainstream view that birds are in fact members of a dinosaurian lineage - they are living dinosaurs.Key Selling features:<li>Explores the evidence supporting the dinosaur ancestry of birds</li><li>Illustrates how fossil and developmental evidence can be integrated</li><li>Reviews the specific nature of putative conflicting evidence</li><li>Synthesizes and resolves different sources of evidence </li>

Interpreting and Resoliving Developmental Evidence

Embryos of Living Dinosaurs

Die Reise des Mondbären

Economic Evaluation in Genomic and Precision Medicine

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