Diagnostic Pathology: Familial Cancer Syndromes

The new edition of Diagnostic Pathology: Familial Cancer Syndromes (DP3: Familial Cancers) is designed to help pathologists and oncologists distinguish familial tumors from their sporadic counterparts and advise patients regarding their possible risk of developing other tumors. The specific clinical, gross, microscopic, imaging, and molecular findings that form the backbone of DP3: Familial Cancers help physicians who diagnose and treat cancer accomplish this, ensuring that a possible syndromic association is not missed. Amid growing interest in hereditary/familial cancer syndromes within all pathology subspecialties, DP3: Familial Cancers is structured to present a significant number of its 180+ chapters by organ and organs involved by syndrome. The graphics-rich environment of DP3: Familial Cancers features thousands of images (including classic radiologic images to broaden the perspective), as well as informative, full-color medical illustrations and flowcharts. The book also contains hundreds of tables organized by body part and/or organ system that include selected existing genetic and familial cancers and identified associated genes, clinical features, recognized manifestations, and staging images/microscopic examples to bolster the information. The book addresses a wide range of inherited tumor syndromes to increase understanding of the gross and histologic features of syndromic-associated neoplasms as well as associated manifestations.

• Thoroughly up-to-date with more than 12 new chapters and updates to nearly a third of the book’s 180 existing chapters, as well as new or updated images, illustrations, and references
• Hundreds of tables organized by body part and/or organ system that include selected existing genetic and familial cancers and identified associated genes, clinical features, recognized manifestations, and staging images/microscopic examples
• An intuitive structure, an easy-to-navigate bulleted text format, and an image-rich layout that together allow for quick reference and comprehensive review of clinically relevant information

DP3: Familial Cancers includes substantial updates throughout, with new chapters, images, and references that reflect the many new diseases and syndromes recognized since the previous edition published in early 2020. Specific additions include the following:

• Updates based on the 2025 WHO Classification of Tumours: Genetic Tumour Syndromes (5^th edition), as well as multiple WHO classifications published since early 2020, including the latest classifications on tumors of the skin, eye, head and neck, and endocrine, including thyroid, lung, kidney, hematolymphoid, within others, which will add details on new discoveries and newly identified diseases and familial syndromes
• An updated Molecular Factors Index, which is an alphabetical listing of all the genes and their locations, as well as their official name/symbol and each chapter where a particular gene is mentioned

Other new material includes the following:

• Updates to chapters based on recently identified diseases and familial syndromes
• Site-specific updates based on the latest WHO Classification
• Details on newest familiar cancer syndromes