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Bhattacharjee M: Chemistry of
Antibiotics and Related Drugs

Chemistry of Antibiotics and Related Drugs

Advanced Drug Delivery Strategies

Nanoengineered Therapeutics for Lung Cancer

Challenges in Delivery of Therapeutic Genomics and Proteomics, Second Edition is a complete reference on the biological principles involved in gene and protein delivery to cells and tissues. Highlighting the various chemical, physical, and biological approaches to protein and gene delivery, the book provides guidelines for pharmaceutical researchers in academia and corporate R&amp;D. This new edition brings updates on the delivery of therapeutic proteomics and genomics in each chapter, and newly developed chapters on the regulatory aspects of related products, CRISPR/Cas9 gene editing, and computational tools in genomics and proteomics. After an overview of the barriers to genomics and proteomics delivery, the book dives into physical, chemical, and biological methods of gene delivery. Further chapters extensively discuss the delivery of proteins and therapeutic peptides through the respiratory, oral, parenteral, transdermal, topical, uterine, and rectal pathways. This book is the ideal reference for pharmaceutical scientists dealing with gene and protein/peptide delivery. Regulators and corporate researchers can also benefit from the wide coverage of delivery methods presented.

Challenges in Delivery of Therapeutic Genomics and Proteomics

Chromatographic Science Series

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Active chemical compounds in the pharmaceutical products existing on the market need to be characterized with respect to their properties, or compared to other similar products, already available for direct use. The book describes sampling methodologies, preparation methods, separation possibilities and assay of these compounds at low concentration levels in complex matrixes. The steps covered are taken before launching a new pharmaceutical product on the market for estimating its pharmacokinetic behavior, or before authorizing for marketing of a generic pharmaceutical product.

Analytical Aspects of Bioequivalence

Woodhead Publishing Series in Biomaterials

Inorganic Biomaterials for Drug Delivery covers a wide range of inorganic biomaterial types and their properties, from traditional materials like ceramics, metallics, and bioglasses to novel composites and nano-engineered inorganic biomaterials. Biocompatibility, toxicity, and regulatory considerations are also thoroughly discussed, ensuring the reader is fully equipped for efficient biomaterials selection and utilization in drug delivery applications. This is a must-have reference for those working in the fields of materials science, biomedical engineering, pharmaceutical science, pharmacology, chemical engineering, and clinical science.

Inorganic Biomaterials for Drug Delivery

Population Genomics

Cells, the basic units of biological structure and function, vary broadly in type and state. Individual cells are the building blocks of tissues, organs, and organisms. Each tissue contains cells of many types, and cells of each type can switch among biological states. Single-cell genomics, transcriptomics and epigenomics open a whole new era with the possibility to interrogate every cell of an organism in order to decipher the important biological processes that occur within. This has emerged as a ground-breaking technology that has greatly enhanced our understanding of the complexity of gene expression dynamics at a microscopic resolution. It is anticipated that in the next 5-10 years, the wider research community will be routinely employing this powerful technology as a laboratory staple. Single-cell genomics, transcriptomics and epigenomics hold the potential to revolutionize the way we characterize complex cell assemblies and study their spatial organization, dynamics, clonal distribution, pathways, function, and crosstalks. These fascinating advances have opened up a new field of cell population genomics.&nbsp; Single-cell genomics, transcriptomics and epigenomics research is providing new insights into inter-cellular population genomic diversity, heterogeneity, specialization, taxonomy, spatial and temporal gene regulation, and cellular and organismal development and evolution. It is facilitating plant breeding, understanding of human disease conditions and personalized medicine. This book discusses the perspectives, progress, and promises of single-cell genomics, transcriptomics and epigenomics research and applications in addressing the above and other key biological aspects in all organisms. It establishes the current state-of-the-field and serves as the foundation for future developments in single-cell genomics, transcriptomics, and epigenomics.&nbsp;

From Cell to Shell

Single-Cell Genomics

Medicinal Chemistry and Drug Development describes the key events and roles of medicinal chemistry in the discovery and development of lead compounds into drugs (including target identification). In 30 case studies, the book covers all stages of drug development, including the discovery of active compounds, research on the pharmacological properties of molecules, and confirmation of drug targets.

Medicinal Chemistry and Drug Development

Clinical Pharmacy and Therapeutics

The Encyclopedia of Lipidomics will present a complete overview of the field from fundamentals to new discoveries and from concepts, theories and experimental techniques to clinical and industrial applications. The book will develop with the active involvement of a strong editorial board comprised of leaders from the field. The Encyclopedia of Lipidomics intends to be a comprehensive reference resource serving to bridge the gap between clinical and basic science investigators and provide authoritative and digested information to students, scientists as well as non specialists. The book will have an edge over protocol type of works and databases in terms of having wider coverage through rigorous essays on terms, concepts, experimental and analytical techniques, applications and new challenges. Since lipidomics has strong linkages with several of the other biomedical and life sciences disciplines, the proposed encyclopedia will have a wide audience including graduate students, researchers and different levels of scientists in biomedicine, cellular and molecular biology, bioengineering, physiological and biochemistry, and pharmacology across both academia and industry.

The Encyclopedia of Lipidomics will present a complete overview of the field from fundamentals to new discoveries and from concepts, theories and experimental techniques to clinical and industrial applications. The book will develop with the active involvement of a strong editorial board comprised of leaders from the field.  The Encyclopedia of Lipidomics intends to be a comprehensive reference resource serving to bridge the gap between clinical and basic science investigators and provide authoritative and digested information to students, scientists as well as non specialists.  The book will have an edge over protocol type of works and databases in terms of having wider coverage through rigorous essays on terms, concepts, experimental and analytical techniques, applications and new challenges.  Since lipidomics has strong linkages with several of the other biomedical and life sciences disciplines, the proposed encyclopedia will have a wide audience including graduate students, researchers and different levels of scientists in biomedicine, cellular and molecular biology, bioengineering, physiological and biochemistry, and pharmacology across both academia and industry.

Encyclopedia of Lipidomics

Pharmaceutical Engineering: A Primer for Advanced Process Development provides a comprehensive, engineering-focused description of pharmaceutical dosage form process development and manufacturing. This volume introduces the most commonly used manufacturing processes for pharmaceutical dosage forms and addresses critical formulation and process parameters that influence drug product process performance and product quality. This is supplemented with detailed descriptions of engineering models as well as tools that can be used to support their development and verification (such as process analytical technology (PAT)) as well as the appropriate utilization of process and equipment knowledge. Typical scale-up challenges inspired by real industrial examples will be presented as well as a review of the latest correlations, theories and models that can form the basis for science-based scale-ups and transfers.

Pharmaceutical Engineering: A Primer for Advanced Process Development

Pharmaceutical QbD with Design of Experiments: Statistical Tools and Applications in Drug Delivery Systems offers comprehensive coverage of best practices in pharmaceutical manufacturing. The first section discusses the principles and basics of Quality by Design (QbD). Part two covers the foundational statistical principles and tools for the Design of Experiments (DoE). Section three is dedicated to the applications of QbD for conventional formulations. The next section provides ample coverage of applications to Novel Drug Delivery Systems (NDDS), including micro and nano-particles. The final section discusses the application of QbD for the optimization of pharmaceutical processes and equipment. Researchers in pharmaceutical manufacturing will benefit from this thorough statistical review, while students in this field will gain practical insights the experienced chapter authors provide in case studies. Industry professionals can find solutions to their particular problems within the insights and strategies shared in this book.

Statistical Tools and Applications in Drug Delivery Systems

Pharmaceutical QbD with Design of Experiments

Woodhead Publishing Series in Biomedicine

Detailed Concepts and Best Practice

Transporters in Drug Discovery and Development

Diese Buch liefert Fachkräften und Studierenden eine Handreichung, das Knowhow zu Planung, Auslegung und Betrieb biotechnologischer Produktionsprozesse zu verbessern.Ein wesentlicher Bestandteil der modernen biotechnischen (Hochschul-)Ausbildung ist die praktische Durchführung von Kultivierungsexperimenten mit Mikroorganismen oder Zellen (tierischen oder humanen) in Bioreaktoren. Allerdings lassen sich dabei meist nur einfache Experimente (z.B. batch-Verfahren) realisieren, da der zeitliche und finanzielle Rahmen begrenzt ist. Ziel dieses in der 3. Auflage erscheinenden&nbsp;Buches ist es, in Verbindung mit einem einfach zu bedienenden Simulator Studierenden der Biotechnologie, Bioverfahrenstechnik, Bioingenieurwissenschaften sowie Technische AssistentInnen ein Werkzeug zur Verfügung zu stellen, das die biotechnologische Ausbildung anhand von ausgearbeiteten Simulationsexperimenten in Hinblick auf die Prozessführung, die Modellierung und die Regelungstechnik unterstützt. Die besondere Stärke des interaktiven Simulators liegt darin, die Lernenden effektiv auf die Durchführung realer Kultivierungsexperimente vorzubereiten. Die Simulation ist auch für einzelne Nutzer außerhalb eines Kurses auf dem privaten PC geeignet.Prof. Dr.-Ing. Volker C. Hass ist Professor für Verfahrenstechnik und Systemdynamik im Institut für Umwelt- und Biotechnik an der Hochschule Bremen. Seit 1995 übt er verschiedene Lehraufträge an der HAW Hamburg, FH Jena und Jacob´s University Bremen aus.&nbsp; Priv.-Doz. Dr.-Ing. Ralf Pörtner ist seit 1990 Oberingenieur und Leiter Arbeitsgruppe „Zellkulturtechnik und Tissue Engineering", TU Hamburg-Harburg, Institut für Bioprozess- und Biosystemtechnik. Er ist Lehrbeauftragter an der FH Gießen-Friedberg , Mitkoordinator des Forschungsschwerpunktes „Regeneration, Implantate und Medizintechnik" der TU Hamburg-Harburg, Sprecher der Forschungsgruppe „Tissue Engineering" sowie Studiengangkoordinator „Bioverfahrenstechnik".&nbsp;

Diese Buch liefert Fachkräften und Studierenden eine Handreichung, das Knowhow zu Planung, Auslegung und Betrieb biotechnologischer Produktionsprozesse zu verbessern.Ein wesentlicher Bestandteil der modernen biotechnischen (Hochschul-)Ausbildung ist die praktische Durchführung von Kultivierungsexperimenten mit Mikroorganismen oder Zellen (tierischen oder humanen) in Bioreaktoren. Allerdings lassen sich dabei meist nur einfache Experimente (z.B. batch-Verfahren) realisieren, da der zeitliche und finanzielle Rahmen begrenzt ist.Ziel dieses in der 3. Auflage erscheinenden&nbsp;Buches ist es, in Verbindung mit einem einfach zu bedienenden Simulator Studierenden der Biotechnologie, Bioverfahrenstechnik, Bioingenieurwissenschaften sowie Technische AssistentInnen ein Werkzeug zur Verfügung zu stellen, das die biotechnologische Ausbildung anhand von ausgearbeiteten Simulationsexperimenten in Hinblick auf die Prozessführung, die Modellierung und die Regelungstechnik unterstützt. Die besondere Stärke des interaktiven Simulators liegt darin, die Lernenden effektiv auf die Durchführung realer Kultivierungsexperimente vorzubereiten. Die Simulation ist auch für einzelne Nutzer außerhalb eines Kurses auf dem privaten PC geeignet.

Bioprozesstechnik

Chemistry of Antibiotics and Related Drugs

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Bibliografische Angaben

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