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Cellular Architecture and Dynamics in
Female Meiosis

Cellular Architecture and Dynamics in Female Meiosis

SpringerBriefs in Entrepreneurship and Innovation

This book examines the impact of demographic decline on digital innovation in the public sector. Utilizing data from Italian municipalities, it provides quantitative and qualitative analyses to reveal the negative impact of demographic decline on digital innovation, which presents a unique challenge for policymakers seeking to foster technological advances in a shrinking, ageing society. This book also investigates the roles of macro-level social, economic, demographic, and administrative factors in the innovation of public organizations. &nbsp;By highlighting these broader demographic dynamics, this book challenges existing theories of public sector innovation, urging greater attention to slow-moving external factors as critical drivers of long-term innovation strategies.

Demographic Shifts and Digital Innovation in the Public Sector

Quaestiones disputatae

Die Entwicklung neuer biotechnologischer Verfahren wie etwa der Genschere oder die zunehmende Bedeutung von Digitalisierung und Künstlicher Intelligenz für die biomedizinische Grundlagenforschung führen zu neuen ethischen Herausforderungen. Die Beiträge des Bandes setzen sich damit auseinander, geben einen Überblick über die aktuelle theologisch-ethische Debatte und ziehen eine Zwischenbilanz.

Die Entwicklung neuer biotechnologischer Verfahren wie etwa der Genschere oder die zunehmende Bedeutung von Digitalisierung und Künstlicher Intelligenz für die biomedizinische Grundlagenforschung führen zu neuen ethischen Herausforderungen. Die Beiträge des Bandes setzen sich damit auseinander, geben einen Überblick über die aktuelle theologisch-ethische Debatte und ziehen eine Zwischenbilanz.

Theologisch-ethische Debatten und Zwischenbilanzen

Anwendungsorientierte Biomedizin und Biotechnologie

Concepts in Reproduction integrates the principal mechanisms of reproduction among eukaryotes, with a focus on animals and plants. The text emphasizes processes and approaches that evolved to address specific problems inherent in reproduction using examples from morphology, functional studies, and genetic studies. The many high-quality figures complement the text and provide visual storyboards. Footnotes and boxes are used throughout to provide depth and to enrich understanding. Information is compartmentalized to guide new readers through complex material while offering in-depth coverage of significant and impactful topics for experts.Key Features¿ Accessibility for a broad audience, using figures that complement the text to explain key concepts and mechanisms ¿ Integrative presentation that emphasizes the science behind the story¿ Breadth of coverage to promote comparative thought¿ Rich multiple-choice questions that span the contentConcepts in Reproduction is recommended for advanced undergraduate students, new graduate students, and investigators or clinicians seeking breadth in their knowledge in the field. The book provides foundational knowledge of fertilization, gametogenesis, primordial germ cell formation, and ontogeny of reproductive organs. Key principles of developmental biology, genetics, endocrinology, protein biochemistry, and molecular and cellular biology are included to tell holistic stories of reproduction among eukaryotes. Later chapters tackle how the field applies these findings to address societal issues.

From Evolution of Mechanisms to Clinical Impact

Concepts in Reproduction

Prevention, Complications, and Treatment

Ovarian Hyperstimulation Syndrome

How the Maternal Body Became a Global Commodity – and the Hidden Costs for Women

Cash Cow

Advances in Anatomy, Embryology and Cell Biology

This book reviews the role of exosomes in both male and female reproduction organs, focusing on the impact of extracellular vesicles on gamete maturation and embryo development.
Fertilization is a complex process involving the fusion of two functionally matured gametes. Maturation of spermatozoa and/ or oocyte dependents on sophisticated, but highly regulated events during gamete transit in the reproductive tracts. Sperm maturation occurs within the epididymis, of which segmented regions provide a distinct microenvironment to facilitate stage-wise maturation processes. Although oocyte maturation occurs within the ovary, communication between oocyte and its surrounding granulosa/cumulus cells is vital for the development and the resumption of meiotically arrested oocytes. Once the oocyte is released from the ovary, the oviductal epithelium continues to facilitate sperm-oocyte interaction to achieve fertilization. Increasing evidence suggests that the uterus, the site for embryo development, also carries out epithelia- embryo communication via uterosomes throughout the pregnancy. All above-mentioned processes rely on orchestrated communications between reproductive tract epithelia and gametes.
In this book, we aim to summarize the origin of secretory vesicles from the reproductive tract and their functions for gamete and embryo development. It is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in extracellular vesicles research.

This book reviews the role of exosomes in both male and female reproduction organs, focusing on the impact of extracellular vesicles on gamete maturation and embryo development.Fertilization is a complex process involving the fusion of two functionally matured gametes. Maturation of spermatozoa and/ or oocyte dependents on sophisticated, but highly regulated events during gamete transit in the reproductive tracts. Sperm maturation occurs within the epididymis, of which segmented regions provide a distinct microenvironment to facilitate stage-wise maturation processes. Although oocyte maturation occurs within the ovary, communication between oocyte and its surrounding granulosa/cumulus cells is vital for the development and the resumption of meiotically arrested oocytes. Once the oocyte is released from the ovary, the oviductal epithelium continues to facilitate sperm-oocyte interaction to achieve fertilization. Increasing evidence suggests that the uterus, the site for embryo development, also carries out epithelia- embryo communication via uterosomes throughout the pregnancy. All above-mentioned processes rely on orchestrated communications between reproductive tract epithelia and gametes.In this book, we aim to summarize the origin of secretory vesicles from the reproductive tract and their functions for gamete and embryo development. It is written for researchers, physicians and medical students working in the field of reproductive science or with an interest in extracellular vesicles research.

Origin, Functions and Perspective

Extracellular Vesicles in Reproduction

This is the first book in a series inspired by the WOOSP (World Congress on Ovulation Induction &amp; Ovarian Stimulation Protocols) Conferences, which were a bi-annual event in India hosted by the IVF Lite Foundation. This volume is based on the updated lectures from WOOSP 2015, held in Seychelles in September 2015.Ovarian stimulation protocols are currently chosen mainly on the basis of personal preferences and individual experience rather than objective evidence based medicine, and in poor responders, as well as in polycystic ovary syndrome (PCOS) patients undergoing assisted reproductive techniques (ART), they constitute a significant challenge for clinicians, even today. Several protocols have been proposed that, when properly utilized, should improve pregnancy rates while keeping potential complications to a minimum. This book defines better predictors of ovarian response to stimulation and allow stimulation protocols to be tailored to individual patients. As such, it is a must-have textbook for clinicians wanting to sharpen their skills and keep abreast of developments in the field.

This is the first book in a series inspired by the WOOSP (World Congress on Ovulation Induction &amp; Ovarian Stimulation Protocols) Conferences, which were a bi-annual event in India hosted by the IVF Lite Foundation. This volume is based on the updated lectures from WOOSP 2015, held in Seychelles in September 2015.Ovarian stimulation protocols are currently chosen mainly on the basis of personal preferences and individual experience rather than objective evidence based medicine, and in poor responders, as well as in polycystic ovary syndrome (PCOS) patients undergoing assisted reproductive techniques (ART), they constitute a significant challenge for clinicians, even today. Several protocols have been proposed that, when properly utilized, should improve pregnancy rates while keeping potential complications to a minimum. This book defines better predictors of ovarian response to stimulation and allow stimulation protocols to be tailored to individual patients. As such,it is a must-have textbook for clinicians wanting to sharpen their skills and keep abreast of developments in the field. &nbsp;

Volume I

Progress in Ovarian Stimulation Protocols

Fifty Studies Every Doctor Should Know

50 Studies Every Endocrinologist Should Know assembles landmark, evidence-based studies in classic endocrinology to guide readers towards solving thorny endocrine problems. Featuring a diverse range of study types--including RCTs, multicenter trials, observational studies, and meta-analyses--this volume addresses the core issues faced by endocrinologists in clinical practice. Each chapter provides a concise summary of key studies, highlighting results, limitations, and practical implications. The chapters conclude with a list of major take-home points, which collectively form a foundation of Endocrine Principles that can be applied to real-word patient problems.

Classic Endocrinology

50 Studies Every Endocrinologist Should Know

Pregnancy and the Novel is a study of covert representations of pregnancy and birth in canonical eighteenth- and nineteenth-century novels. The research draws on medical texts to illuminate the ways that novelists simultaneously hide and reveal problematic pregnancies and births. Grounded in narrative theory and historicism, it reveals a reciprocal influence between literature and science through the novels of Samuel Richardson, the Brontës, George Eliot, Dickens and Hardy. This project is an act of literary detective work that will uncover what can easily be missed by twenty-first century readers, bringing it into light by reconstructing historical knowledge of reproductive medicine.This is an open access book.

Pregnancy and the Novel is a study of covert representations of pregnancy and birth in canonical eighteenth- and nineteenth-century novels. The researchdraws on medical texts to illuminate the ways that novelists simultaneously hide and reveal problematic pregnancies and births. Grounded in narrative theory and historicism, it reveals a reciprocal influence between literature and science through the novels of Samuel Richardson, the Brontës, George Eliot, Dickens and Hardy. This project is an act of literary detective work that will uncover what can easily be missed by twenty-first century readers, bringing it into light by reconstructing historical knowledge of reproductive medicine.This is an open access book.

Detection and Concealment from Richardson to Hardy

The Pregnancy Question and the Novel

Methods in Molecular Biology

This volume details various aspects of the very final stages of mouse oocyte development, and very early embryo development. &nbsp;Chapters present methods ranging from in vitro&nbsp;growth of follicles, ewe oocytes, meiosis, identification of LADs (Lamin Associated Domains)/TADs (Topological Associated Domains), analysis of the oocyte, early embryo transcriptome, and mechanical characterization of these cells. Written in the highly successful Methods in Molecular Biology series format, the chapters include brief introductions tothe material, lists of necessary materials and reagents, step-by-step, readilyreproducible laboratory protocols, and a Notes section which highlightstips on troubleshooting and avoiding known pitfalls.&nbsp;Authoritative and cutting-edge, Mammalian Oocyte Development: Methods and Protocols, aims to be comprehensive guide forresearchers in the field.

Methods and Protocols

Mammalian Oocyte Development

Current Topics in Microbiology and Immunology

This edited volume discusses the evolution of cell death in microorganisms by providing new theoretical models and experimental studies of microorganisms, both prokaryotes and eukaryotes. It incorporates the latest findings and evidence for bacterial self-destruction, cell-death in multicellular fungi, and potential cell-death mechanisms in unicellular species of algae, parasites, and pathogenic yeast.Mechanisms of self-destruction by individual cells were assumed to arise during evolution with multicellular organisms, which require cell death to generate the complex structures of plants and animals. Current opinion, however, supports an alternative evolutionary history. Arguments from biologists and theorists suggest that programmed cell death likely pre-dates the evolution of multicellular organisms. This volume will prove valuable for microbiologists and cell biologists working in the field of molecular evolution and apoptosis research and might spark new ideas for future applications in science and medicine.&nbsp;

Self-Induced Cell Death in Microorganisms

Series in Maternal-Fetal Medicine

This edition, like the previous editions of this successful text, tries to summarize the controversies and discuss the scientific basis for various causes of Recurrent Pregnancy Loss in depth and to clarify the various treatment modalities.

Causes, Controversies and Treatment

Recurrent Pregnancy Loss

Cellular Architecture and Dynamics in Female Meiosis

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