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Gesamtkatalog

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Deimling G: Cancer Survivors in Later
Life

Cancer Survivors in Later Life

No-RT and Beyond RT

Individualized Treatment Strategies in the Radiotherapy Era

Endocrinology

Neuroendocrine Neoplasia

Imaging in Medical Diagnosis and Therapy

Proton Radiography and Tomography for Medical Applications

Proton Imaging Technology

Cholesterol Metabolism in Aging and Disease provides in-depth coverage on the mechanistic intersection between the aging process and cholesterol metabolism. The book covers the discovery of cholesterol, its biochemistry, and how it came to have such a prominent role in aging and disease. Important areas such as cholesterol biosynthesis and cellular cholesterol homeostasis are described in detail. Technological advancements in computational modeling are also discussed to help improve our understanding of cholesterol metabolism so that new therapeutic avenues are opened to help treat age-related diseases associated with the dysregulation of this key system. This is a must have reference for students and researchers interested in, or working in, various aspects of aging. In addition, it is ideal for clinician researchers and gerontologists.

Cholesterol Metabolism in Aging and Disease

This textbook provides insights into common benign and malignant diseases of the upper gastrointestinal tract, including the esophagus, stomach, and small intestine, covering anatomy, cancer, and functional diseases. Divided into 11 sections, the book offers up-to-date insights into epidemiology, physiology, pathology, diagnosis, treatment, and care with an emphasis on advanced treatments, including surgery, therapy, and radiotherapy, from both eastern and western perspectives. Chapters address specific conditions such as esophageal and gastric cancer, along with innovative approaches to surgery and systemic treatments. It also discusses key concepts in bariatric surgery, small intestine disorders, and postoperative care. The book is supplemented with ample illustrations to tackle the challenges of treating diseases in the upper gastrointestinal regions due to the complex anatomy, aggressive biological behavior, and poor prognosis.The IASGO Textbook of Multi-Disciplinary Management to Upper Gastrointestinal Diseases aims to update academic and non-academic medical professionals, including gastroenterologists, gastrointestinal surgeons, general surgeons, radiation oncologists, medical oncologists, interventional radiologists, general practitioners, bariatric specialists, residents, medical students, and scientists, to gain insights into the understanding of upper gastrointestinal health and management.&nbsp;

The IASGO Textbook of Multi-Disciplinary Management to Upper Gastrointestinal Diseases

THE INSTANT SUNDAY TIMES BESTSELLER! 'Only Sophie Kinsella can make you laugh like this while she's got you crying . . . This is one of the gutsiest moves I've seen from a writer in a long time. I could not put it down.' TAYLOR JENKINS REID 'A deeply funny and affecting love story.' The Guardian 'I laughed. And I cried. And then I thought about the meaning of life. A jewel of a book.' JOJO MOYES 'Emotional and affecting, this gave me a new appreciation for life's small joys.' Red 'The bravest book you'll read all year.' JODI PICOULT ------------------ From Number One bestselling author Sophie Kinsella, an unforgettable story - by turns heartbreaking and life-affirming - of a renowned novelist facing a devastating diagnosis and learning to live and love anew. 'What Does It Feel Like? is fiction, but it is my most autobiographical work to date. Eve's story is my story.' - SOPHIE KINSELLA Eve is a successful novelist who wakes up one day in a hospital bed with no memory of how she got there. Her husband, never far from her side, explains that she has had an operation to remove the large, malignant tumour growing in her brain. As Eve learns to walk, talk, and write again - and as she wrestles with her diagnosis, and how and when to explain it to her beloved children - she begins to recall what's most important to her: long walks with her husband's hand clasped firmly around her own, family game nights and always buying that dress when she sees it. Recounted in brief anecdotes, each one is an attempt to answer the type of impossible questions recognizable to anyone navigating the labyrinth of grief. This extraordinary novella is a celebration of life, shot through with warmth and humour - it will both break your heart and put it back together again. 'Why did I write such a personal book? I have always processed my life through writing. Hiding behind my fictional characters, I have always turned my own life into a narrative. It is my version of therapy, maybe. Writing is my happy place, and writing this book, although tough going at times, was immensely satisfying and therapeutic for me.' - SOPHIE KINSELLA ------------------ 'I was gripped and moved and I loved every word.' LISA JEWELL 'A beautiful love story and a glowing beacon of hope.' JENNY COLGAN 'Heartbreaking yet hopeful, this life-affirming read encourages us all to take life by the horns.' Prima 'Of all the books I have read about living with cancer this is by far the best. Beautifully written, profound and deeply moving.' HENRY MARSH Sophie Kinsella, Number 1 Sunday Times bestseller, June 2024 Sophie Kinsella, Sunday Times bestseller, October 2024

What Does it Feel Like?

Mechanisms, Biomarkers, and Therapeutic Implications

Extrachromosomal DNA in Cancer

Time wants you dead. Not just you, but your friends, family, pets - everyone you've ever met...

'A beautifully written book about life and death: busts myths, explores the stories of science and history, and ultimately is rich and uplifting.' Dr Adam Rutherford

With over 17,000 known diseases affecting humans, and countless poisons, carcinogens and toxins in our environment, it's a miracle that our bodies manage to keep us alive. And that is, of course, if they don't betray us themselves, whether through cancers or autoimmune conditions.

Biomedical researcher Professor John Tregoning tells the unlikely story of how, against all odds, we manage to stay alive. Taking an organ-by-organ tour of the human body, Tregoning embarks on his own experimental quest, testing 'life-extending' diets and exercise regimes to separate fact from fad. Exploring the multitude of ways our bodies can kill us, from inherited genetic conditions, through heart attacks, arrythmias and angina, onto the delicate workings of the brain, Live Forever?&nbsp;offers compelling insight into how our bodies work, how we can best look after them - and ultimately live longer, healthier lives.

***

'I heartily recommend this deep dive into wellness... It turns out that none of us are getting out of here alive, but John has bravely put his mind and body on the line to discover the secrets of staying healthy and happy as we get older. A funny, fascinating and educative book.' Ben Willbond, co-creator of Ghosts

'The idea that a book about death and dying could be a delightful read seems ridiculous, and yet John Tregoning has pulled off this trick with humour, flair and elegance.' Nessa Carey, author of The Epigenetics Revolution

'An enjoyable and entertaining mixture of scientific facts about ageing and completely unscientific self-experimentation... recognizing that although none of us will live forever, there are ways we can improve our chances of living well while we are still around.' Dame Sarah Gilbert

A Curious Scientist’s Guide to Wellness, Ageing and Death

Live Forever?

A Johns Hopkins Press Health Book

A trusted, updated guide to understanding chronic pain and reclaiming your quality of life.Confronting Chronic Pain is a clear, compassionate, and up-to-date guide to understanding and managing one of the most common and complex health challenges: long-term, persistent pain. Written by two leading pain specialists, this trusted resource distills decades of clinical expertise into an accessible, practical handbook for individuals living with pain and those who care for them. This revised edition reflects major changes in the medical understanding of pain and its treatment. Readers will find insights on conditions such as arthritis, fibromyalgia, back pain, neuropathy, chronic headaches, and cancer-related pain, along with the latest options for relief. The authors explore traditional therapies and emerging treatments, including new minimally invasive procedures, improved migraine medications, and advances in neurostimulation. While examining the evolving role, risks, and best practices for opioid use, they also highlight promising non-opioid alternatives--from physical therapy and anti-inflammatory strategies to antidepressants, anticonvulsants, and innovative topical or injectable treatments.Beyond the physical manifestations of pain in the body, Confronting Chronic Pain explores the psychological, social, and spiritual aspects of pain. Chapters on family dynamics, emotional resilience, and communication with health care providers help readers take an active role in their care and reclaim their quality of life.

A Guide to Relief

Confronting Chronic Pain

Provisional text
This book provides a comprehensive review of innovative diagnostic methods for prostate cancer, with a particular emphasis on the development of PET radiopharmaceuticals. The author has had the privilege to introduce several tracers into clinical routine practice, including Na18F, 18F-FCH, 18F-FACBC, 68Ga-PSMA11, 18F-PSMA-1007, and 18F-DCFPyL. Thus, indications in various prostate cancer subgroups are discussed in detail, weighing the pros and cons in clinical practice. In the authors´ practice radiation therapy has been more important and surgical applications; therefore, PET based dose planning is presented in detail. Furthermore, the author has closely followed the development of radiopharmaceutical treatments, particularly in the context of bone pain palliation using radiopharmaceuticals, such as 89SrCl2, 186ReHEDP, 153SmEDTMP, 117mSnDTPA, and 223RaCl2, and targeted treatments (177Lu-PSMSA-617, 177Lu-PSMA-I&amp;T and 225Ac-PSMA).
Thanks to his experience, the author facilitated the set-up of targeted treatments in various countries: Baltic and Nordic countries, elsewhere in Europe, North America (Canada), and Africa (e.g. Ghana). The author's involvement in promoting therapy tourism to Finland further highlights his breadth of knowledge and practical experience.
This book offers valuable insights into the evolving landscape of diagnostic methods and radiopharmaceutical treatments for prostate cancer. With the author's extensive experience and contributions to the field, readers can gain a comprehensive understanding of these advancements and their implications in clinical practice.

A personal Journey

Prostate Cancer from a Nuclear Oncology Perspective

Oxford Medical Handbooks

Oxford Handbook of Geriatric Medicine

Individual tumour molecular profiling and tacking dynamic evolution by treatment related selective pressure are crucial for clinical oncology. However, current tissue biopsy cannot represent spatial and temporal tumour heterogeneity due to sampling bias. 

Liquid biopsy is an alternative way of tissue biopsy since it can represent comprehensive molecular signature from multiple distinct lesions and real time tracking is feasible by repeated longitudinal assay during course of treatment.

This book describes current knowledge regarding pre-analytical issues including standardization of blood preparation, analytical variability, clinical application and regulatory agency approval issue, etc. Regarding targets in circulation, it focuses on circulating tumour cells (CTCs), circulating nucleic acid (ctDNA, cell free RNAs), extracellular vesicles, tumour educated platelets, and others (proteins, metabolites).

The book will be a rich source of information and instruction for oncologists and offers stimulating ideas on prospects for further progress in this field.

Individual tumour molecular profiling and tacking dynamic evolution by treatment related selective pressure are crucial for clinical oncology. However, current tissue biopsy cannot represent spatial and temporal tumour heterogeneity due to sampling bias.&nbsp;Liquid biopsy is an alternative way of tissue biopsy since it can represent comprehensive molecular signature from multiple distinct lesions and real time tracking is feasible by repeated longitudinal assay during course of treatment.This book describes current knowledge regarding pre-analytical issues including standardization of blood preparation, analytical variability, clinical application and regulatory agency approval issue, etc. Regarding targets in circulation, it focuses on circulating tumour cells (CTCs), circulating nucleic acid (ctDNA, cell free RNAs), extracellular vesicles, tumour educated platelets, and others (proteins, metabolites).The book will be a rich source of information and instruction for oncologists and offers stimulating ideas on prospects for further progress in this field.The translation was done with the help of artificial intelligence. A subsequent human revision was done primarily in terms of content.

Current Status and Future Challenges

Liquid Biopsy for Cancer

Cancer Survivors in Later Life

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