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Endocrine Development

Calcium and Bone Disorders in Children
and Adolescents

Calcium and Bone Disorders in Children and Adolescents

Advancements in the field of school-based health have improved the overall health and mental well-being of students. With these advancements, school-based health providers must be aware of the latest clinical evidence and technologies in order to provide optimal care for their students. The purpose of this book is to provide school-based health providers a comprehensive, “go-to” resource to access evidence-based recommendations for the assessment/screening, triage, initial stabilization and treatment, and recognition of acute and chronic conditions and disease processes often seen in students. It aims to utilize modern methods of learning for the audience to improve retention and implementation, such as algorithms, mnemonics, infographics, case studies, tables and lists, etc. Authors have been recruited, both regionally and nationally, with expertise in school-based health, and include clinical physicians, school nurses and advance practice providers.The text is structured into ten main sections covering an array of topics, including medical conditions and disease, trauma and sports medicine, and mental/behavioral health. Each chapter is structured with a brief description of the topic, innovations within the topic/field (including current research), screening or recognition of the disease or injury, care plans for students with the disease or injury, complications associated with the disease or injury that may present in the school setting, triage based on the presentation (either to an emergency department, urgent care center, primary care physician’s office, or remain in school), and the future of each topic/field/diagnosis with respect to school-based health.Clinical Considerations in School-based Health is innovative in that the focus is on clinical school-based health highlighting recommendations based on the evidence and research, on utilizing innovative methods of learning (algorithms, mnemonics, infographics, case studies, etc.), covering “hot topics” not often seen in other school-based health books and resources, and targeting all stakeholders in school-based health.&nbsp;

An Evidence-Based Guide for Physicians, Advanced practice providers and School nurses

Clinical Considerations in School-based Health

*With a foreword from New York Times bestselling author of THE NEW MENOPAUSE, Dr Mary Claire Haver*YOUR PLAYBOOK FOR OPTIMISING YOUR RESULTS GLP-1s (Mounjaro, Ozempic, Wegovy) are creating a huge buzz in medicine. They instigate rapid weight loss, suppressing appetite and cravings. There is increasing evidence of many powerful additional health benefits, so they have even been touted as miraculous. But the eternal question is: after you've lost the weight, how can you sustain that lifestyle for the long term?In WEIGHTLESS, Dr Salas-Whalen will take readers along a comprehensive health journey that begins before starting on GLP1s, though the entire process of weight loss and muscle retention process, and beyond that - to the life after the weight loss goals are achieved. The book discusses everything from understanding how GLP1-s work and navigating side effects, to managing your mindset around weight loss, getting enough protein, long-term lifestyle changes, and so much more. Dr Salas-Whelan's voice is authoritative and encouraging. She will share case studies from patients who experienced relatable issues along their journeys, and how she coached them to the other side of a roadblock. WEIGHTLESS is your handbook for long-term, sustainable weight loss and vitality.

A Doctor’s Guide to Optimising GLP-1 Results, Sustaining Weight Loss and Achieving the Health You Deserve

Weightless

Das erste Buch für die Kinder- und Jugendmedizin zum Thema Klimawandel behandelt praxisnah den aktuellen Stand von konkreten Umgangs- und Lösungsmöglichkeiten spürbarer klimabedingter Gesundheitsprobleme in der Pädiatrie. Kinder und Jugendliche sind aufgrund ihrer Physiologie und ihrer Entwicklung besonders vom Klimawandel betroffen. Die Autoren und Autorinnen aus der Kinder- und Jugendmedizin, Inneren Medizin sowie Psychologie sprechen daher die Gesundheitsthemen an, die im Alltag in der Praxis und in der Klink bereits heute relevant sind.Ein Leitfaden, der die Problematik allen kinderärztlich Tätigen schnell zugänglich macht und praktische Lösungen bietet, auf klimabedingte Erkrankungen und Störungen einzugehen und gleichzeitig Prävention zu ermöglichen.Der InhaltPneumologie, Allergologie und Kinderdermatologie – Infektiologie – Auswirkungen von Hitze – Psychische Gesundheit – Pflanzenbasierte Ernährung – Klimasensible GesundheitsberatungDer HerausgeberPD Dr. med. Dirk Holzinger&nbsp;ist Facharzt für Kinder- und Jugendmedizin und Gesundheitswissenschaftler. Er ist als Oberarzt der Pädiatrischen Rheumatologie und Immunologie am Zentrum für Kinder- und Jugendmedizin am Universitätsklinikum Essen tätig. Zudem hat er eine Vertretungsprofessor für Kinder- und Jugendmedizin im Department für Pflege-, Hebammen- und Therapiewissenschaften an der Hochschule Bochum inne und ist Vorstandsmitglied bei KLUG (Deutsche Allianz für Klimawandel und Gesundheit e.V.).

Kindergesundheit und Klimawandel

Handbook of Clinical Neurology

The evolution of neuroimmunotherapies with the concurrent progress in autoimmune neurology will introduce the book, followed by an update on "non-targeted" therapies highlighting the value of immunosuppressants, plasmapheresis, IVIg or hematopoietic bone marrow transplantation and their mode of action in autoimmune neurology. The new agents in each of these categories, along with biomarkers for therapeutic monitoring and the application of reliable scales in assessing response, will be covered. Chapters will discuss how neuroimmunotherapies work when key molecules and pathways associated with CNS or PNS tissue damage are targeted or inhibited. The volume will describe the approved agents targeting: 1) T-cell intracellular signaling pathways and molecules associated with antigen presentation; 2) B cells, B-cell trophic factors, and autoantibodies; 3) Fc receptor modulation; 4) complement; and 5) cytokines, cell adhesion and transmigration molecules. Didactic schemes and illustrations on how these drugs work in autoimmune neurological diseases will be provided in each chapter. The second part of the book will discuss the latest therapeutics for each major autoimmune neurological disease, aimed to provide a reliable, comprehensive and up-to-date source of information useful for clinical practice and education. Didactic and practical algorithms, a step-by step approach on how best to apply the most suitable therapies for a given state of the disease or proceed to escalation therapies will be provided. Treatment controversies and uncertainties will be authoritatively emphasized by scholars in each field. A chapter addressing potential immunotherapeutic approaches, now on the pipeline or on early trials, as future means of treating some neurodegenerative diseases will be included. Another chapter will cover the new and popular-although controversial -concept of treating autoimmune pain. The book discusses practical therapies with¿traditional immunosuppressants, steroids and IVIg. It describes targeted therapies with monoclonal antibodies or fusion proteins against B cells , T cells, complement, and FcRn, discussing what happens when key factors related to neurological autoimmunity are inhibited. The book provides a "how- to- do" approach for each of the major autoimmune diseases with algorithms and escalation therapies. Dedicated chapters will cover current therapies on encephalitis, NMOSD, Multiple sclerosis , autoimmune neuropathies, myopathies, neuromuscular junction disorders and neuroexcitability disorders like stiff person syndrome. The book is aimed for practitioners and academicians as a reliable and comprehensive source for applying neuroimmunotherapies and understanding their mechanisms.

Immunotherapies for Neurologic Diseases: Volume 214

The Clinics: Internal Medicine

Endocrine and Metabolic Emergencies in Emergency Medicine, An Issue of Endocrinology and Metabolism Clinics of North America: Volume 55-1

In this issue of Endocrinology and Metabolism Clinics, guest editors Drs. Caroline M. Apovian and Dong Wook Kim bring their considerable expertise to the topic of Update on Obesity. Top experts in the field cover the latest research regarding weight loss drugs, drug safety, pharmacotherapy, AI, and nutritional/lifestyle changes for managing obesity.<ul><li>Contains 15 relevant, practice-oriented topics including drug safety and pharmacovigilance of anti-obesity medications; obesity stigma; non-pharmacological treatment for obesity; artificial intelligence and obesity management; intermittent fasting and obesity; and more</li><li>Provides in-depth clinical reviews on obesity, offering actionable insights for clinical practice</li><li>Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews</li></ul>

Update on Obesity, An Issue of Endocrinology and Metabolism Clinics of North America: Volume 54-1

Metabolic Memory: Past, Present and Future Implications delves into the emerging concept of metabolic memory, exploring how our body's metabolic processes retain a 'memory' of past experiences and how this impacts our current and future health. Drawing on the latest scientific research this book aims to bridge the gap between complex scientific concepts and their practical implications for everyday health and wellness. Metabolic memory has profound implications for understanding chronic diseases, particularly diabetes, cardiovascular diseases, and obesity. Despite its significance, there is a lack of comprehensive resource that make this information accessible to both professionals and the general public. This book fills that gap, providing a detailed yet understandable exploration of how past metabolic states influence present and future health outcomes.

Past, Present and Future Implications

Metabolic Memory

Environmental and Comparative Endocrinology

Fatigue is a prevalent problem and adequate treatment is challenging because many conditions, disorders, medications, and lifestyle factors can cause fatigue. The Scientific Basis of Fatigue combines evidence-based research and clinical treatment protocols to provide a comprehensive reference to fatigue. This book is divided into seven distinct sections, starting with an introduction section defining the distinctions between physical and mental fatigue. The second and third sections detail the various conditions in both physical and mental fatigue including COVID, Parkinson disease, and depression. The next section reviews the current research on molecular and cellular aspects and models of fatigue. The final two sections review options for diagnosis and treatments for fatigue and provides a detailed resource section for further review.

The Scientific Basis of Fatigue

The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity is a critically acclaimed account detailing the groundbreaking discovery of the hormone GLP-1, narrated by the award-winning scientist Professor Jens Juul Holst, along with co-authors Professor Sten Madsbad, Professor Jens Meldgaard Bruun, and Mads Krogsgaard Thomsen, CEO of the Novo Nordisk Foundation. GLP-1 is the hormone found in weight loss medications and diabetes treatments such as Ozempic and Wegovy. The discovery of GLP-1 has significantly transformed treatment options for individuals with type 2 diabetes and obesity, offering benefits that include improved blood glucose regulation and substantial weight loss, while also lowering the risk of related complications. Professor Jens Juul Holst, MD, DMSc, is among the world's leading diabetes researchers, having pioneered the discovery of GLP-1 in the 1980s. In this book, we follow the historical research journey that led to the identification of this hormone, which now signifies a paradigm shift in the management of diabetes and obesity. "The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity" narrates the rising rates of obesity and diabetes, underscoring a critical public health issue, even in light of considerable progress in treatment alternatives. While traditional approaches, such as low-calorie diets, have shown potential for short-term weight loss, maintaining that loss has proven difficult. Efforts to achieve better blood sugar control have not consistently translated into reduced complications or improved patient outcomes, as demonstrated by extensive international studies. However, the introduction of new diabetes medications, particularly those based on glucagon-like peptide-1 (GLP-1), such as liraglutide and semaglutide, has marked a significant breakthrough. These medications not only improve blood sugar levels but also promote substantial weight loss and reduce cardiovascular complications, offering hope for better management of obesity and diabetes. Despite these promising results, challenges remain regarding accessibility and affordability of these treatments, raising important societal questions about who should receive them and how they should be funded. The author's involvement in the discovery and development of GLP-1 provides a unique perspective on the historical and physiological context of these advancements, making this book a valuable resource for understanding the complexities of metabolic diseases and the evolution of treatment options.

A Historical Journey in the Treatment of Diabetes and Obesity

The Story of GLP-1

Pediatrics is an evolving field of medicine and with many new advancements in knowledge, scientific research, and technology in recent&nbsp;years. This concise and comprehensive 2nd Edition of the textbook "Update in Pediatrics" provides an update and overview of the latest advances and current literature in Pediatrics, assisting health professionals to review cutting-edge information&nbsp;in the different subspecialties in Pediatrics.&nbsp; This book is structured into chapters based on the various subspecialties in Pediatrics, and includes chapters ranging from traditional disciplines such as Infectious Disease and Cardiology, to more current disciplines such as Adolescent Medicine and Child Maltreatment. The team of authors is made up of experienced and expert clinicians and researchers in their respective fields. The target audience for this book includes any practitioner who cares for children, including pediatricians, family doctors, nurses and nurse practitioners, allied health professionals, residents,&nbsp;medical students,&nbsp;and health researchers providing an indispensable resource for the busy clinician and learner who wishes to stay up-to-date with the latest advances and knowledge in the field.

Update in Pediatrics

Thorax-Bildgebung bei Neugeborenen und Kindern – So geht dasDie radiologische Diagnostik bei Neugeborenen, Säuglingen und Kindern stellt besondere Herausforderungen: Die Patient:innen sind besonders schutzbedürftig, die Fallzahlen im klinischen Alltag oft gering, und die Anforderungen an Technik, Methodik und Strahlenschutz hoch. Dieses Buch bietet eine fundierte, verständlich aufbereitete Einführung in die Thoraxbildgebung bei dieser sensiblen Patientengruppe – ideal für den klinischen Alltag, die Weiterbildung und den sicheren Einstieg in die pädiatrische Radiologie.Im Fokus stehen der gezielte und indikationsgerechte Einsatz bildgebender Verfahren – von der Röntgendiagnostik über Sonografie und CT bis hin zur MRT. Neben der technischen Durchführung werden auch die altersspezifischen Normalbefunde (die sich maßgeblich vom Erwachsenen unterscheiden), typische Befunde bei Neugeborenen und Kindern (mit Fokus auf Pathologien, die für diese Altersgruppen spezifisch sind), Differenzialdiagnosen und klinisch relevante Zusatzinformationen ausführlich dargestellt. Zahlreiche Abbildungen und Fallbeispiele erleichtern das Verständnis und fördern die praktische Anwendung.Neu in dieser Auflage:<ul><li>Erweiterung um thorakale Erkrankungen jenseits der Neugeborenenperiode</li><li>Kapitel zum leitliniengerechten Vorgehen – kompakt, verständlich und praxisnah</li><li>14 Fallbeispiele zur interaktiven Befundung in Quizform</li></ul>Das Buch richtet sich an Radiolog:innen, Pädiater:innen, Kinderchirurg:innen, Kinderradiolog:innen sowie an alle, die sich in der Aus-, Weiter- oder Fortbildung mit der Bildgebung des kindlichen Thorax befassen. Es bietet sowohl eine strukturierte Einführung als auch ein praxisorientiertes Nachschlagewerk für den klinischen Alltag.

Sicher diagnostizieren – Thoraxbildgebung bei Neugeborenen und Kindern meisternViele haben Angst vor der Arbeit mit Neugeborenen und Kindern – sind sie doch vulnerabel und besonders schützenswert. Außerdem machen sie, auch in der Aus- und Weiterbildung, nicht den Großteil der radiologischen Alltagsarbeit aus und sind daher wenig vertraut. Dieses Buch versucht, den optimierten und gezielten Einsatz bildgebender Verfahren für die Thoraxdiagnostik bei Neugeborenen, Säuglingen und Kindern verständlich und umfassend zu beschreiben – auch als leichter Einstieg, der alle Themenbereiche abdeckt, in verständlicher Weise gehalten ist und durch die vielen Beispiele praxisbezogen wirkt.Auch die anspruchsvollen Anforderungen an die Geräteausstattung und Untersuchungstechnik werden unter besonderer Berücksichtigung des Strahlenschutzes bei Kindern behandelt. Reich bebildert und ausführlich werden typische – und nicht nur häufige – Befunde bei Erkrankungen und Fehlbildungen im kindlichen Thorax dargestellt. Differenzialdiagnosen und klinische Informationen, die für die Verfahrenswahl und die Interpretation der Befunde von Bedeutung sind, werden diskutiert. Umfangreicher als in der ersten Auflage werden nun auch thorakale Erkrankungen jenseits der Neugeborenenperiode behandelt. Neu ist ein Kapitel zum leitliniengerechten Vorgehen, das versucht, einige aktuelle, teils „sperrige“ Leitlinien auf das Wesentliche konzentriert zu vermitteln. Anhand von 14 Beispielfällen, die das gesamte Spektrum thorakaler Erkrankungen umreißen, kann die Befundung in Quizform trainiert und geübt werden.

Bildgebung des Thorax bei Neugeborenen und Kindern

Calcium and Bone Disorders in Children and Adolescents

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