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Bone and Joint Infections

Unspezifische Rückenschmerzen sind relevant für das Gesundheitssystem und zählen zu den häufigsten Volkskrankheiten. Körperliche Aktivität und Sport haben sich in der Therapie und Prävention als evident erwiesen. Das Kompendium bietet einen großen Fundus an Übungen und Trainingsempfehlungen bei Rückenschmerzen, die aus dem interdisziplinären Projekt „Ran Rücken“ durch das nationale Forschungsnetzwerk „Medicine in Spine Exercise“ (MiSpEx) gewonnen wurden.Physiotherapeuten, Sportwissenschaftler und Übungsleiter von Rückengruppen finden in diesem Buch eine Vielzahl von Übungen zur Behandlung von unspezifischen Rückenschmerz nach dem perturbationsgestützten sensomotorischen Konzept. Die Anleitungen sind bebildert und einfach beschrieben, zudem ergänzen Videos die richtige Umsetzung. Bei entsprechender Dosierungs- und Übungsgestaltung ist diese Methode für eine breite Zielgruppe, von der Allgemeinbevölkerung bis hin zum Leistungssport, einsetzbar.Inhalt:<ul><li>Grundlagen</li><li>Trainingsdosierung und Umsetzung</li><li>Übungen und Trainingsempfehlungen&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;</li></ul>Autoren:Prof. Dr. F. Mayer, Universität Potsdam, Hochschulambulanz, Sportmedizin &amp; SportorthopädieDr. Tilmann Engel, Universität Potsdam, Hochschulambulanz, Sportmedizin &amp; SportorthopädieDr. Josefine Stoll, Universität Potsdam, Hochschulambulanz, Sportmedizin &amp; Sportorthopädie

Unspezifische Rückenschmerzen sind relevant für das Gesundheitssystem und zählen zu den häufigsten Volkskrankheiten. Körperliche Aktivität und Sport haben sich in der Therapie und Prävention als evident erwiesen. Das Kompendium bietet einen großen Fundus an Übungen und Trainingsempfehlungen bei Rückenschmerzen, die aus dem interdisziplinären Projekt „Ran Rücken“ durch das nationale Forschungsnetzwerk „Medicine in Spine Exercise“ (MiSpEx) gewonnen wurden.Physiotherapeuten, Sportwissenschaftler und Übungsleiter von Rückengruppen finden in diesem Buch eine Vielzahl von Übungen zur Behandlung von unspezifischen Rückenschmerz nach dem perturbationsgestützten sensomotorischen Konzept.&nbsp; Die Anleitungen sind bebildert und einfach beschrieben, zudem ergänzen Videos die richtige Umsetzung. Bei entsprechender Dosierungs- und Übungsgestaltung ist diese Methode für eine breite Zielgruppe, von der Allgemeinbevölkerung bis hin zum Leistungssport, einsetzbar.

Übungsanleitungen für Therapeuten, Sportwissenschaftler und Übungsleiter

Praxiskompendium Rückenschmerz und Sport

This book provides in-depth insights into the pathogenesis and therapeutic strategies of biofilm induced infections. It presents strong interdisciplinary viewpoints on infection biology, pharmacology, drug discovery, diagnosis and therapeutics.The rising burden of antibiotic resistance induced by bacterial biofilm formations makes it imperative to understand the root cause of infection. Hence, it is necessary to enhance clinical and non-clinical understanding of biofilm development and its role in infectious diseases. This book provides detailed information on the role of biofilm formation in various diseases including brief descriptions of the molecular mechanisms and contributing factors. This book also discusses the therapeutic strategies for reducing biofilm induced infection as well as the issues with the present treatment options. Detailed discussions on the role of bacterial biofilms in dental disease, tonsilitis, tuberculosis, typhoid, endocarditis, ulcer, bone infections, urinary tract infections, chronic wound infections and cancer have been presented individually in chapters 6-15. Collectively this book serves as a fundamental yet up-to-date guide on the implications and challenges of bacterial biofilm induced chronic infections.This book is primarily targeted at researchers, undergraduate and postgraduate students in departments of microbiology / biotechnology with interest in bacterial infection, biofilm development, drug resistance, disease chronicity, biomonitoring, therapeutics etc etc. It will also be of interest to clinicians dealing with bacterial infection and industrialists who aim to produce specific antibiofilm agents.

Role in Disease Pathogenesis and Therapeutic Strategies 

Bacterial Biofilm and Chronic Infections

Current Topics in Microbiology and Immunology

This volume explores in detail the molecular biology, genetics and immunology of the bacterium Helicobacter&nbsp;pylori that causes serious gastric diseases such as gastric cancer. The book provides in-depth insights into the mechanisms of H.&nbsp;pylori-induced pathogenicity, gives an overview of how the bacterium colonizes the human gut, how it manages to persist in the body and which factors play a role in the development of H. pylori-induced gastric cancer. Furthermore, the interaction between the Gram-negative bacterium and the human gut microbiome is explored, and clinical management and treatment strategies to combat gastric cancer are discussed.Helicobacter pylori is an extremely successful pathogen that persistently colonizes the gut of about 50% of the world's population. H.&nbsp;pylori and its human host share a long co-evolutionary relationship that dates back for at least last 100,000 years and possibly longer. Infection by this bacterium is a high-risk factor for the development of gastric diseases, including gastric cancer. Gastric cancer is associated with high morbidity and mortality and represents the 5th most common malignant tumour and the 4th leading cause of cancer-related death worldwide. H.&nbsp;pylori is the first bacterium that has been classified as a type-I carcinogen by the International Agency for Research on Cancer (IARC). Recent research progress identified crucial bacterial, host and environmental factors which control H.&nbsp;pylori-induced gastric malignancy. New studies also suggest that specific human germline mutations and other genetic aberrations have an important impact on H. pylori-induced pathology. In this volume, all these recently discovered mechanisms are reviewed in the light of gastric cancer development, and H.&nbsp;pylori epidemiology, virulence factors, immune evasion, pathophysiology, cancer signalling and novel therapeutic protocols are presented.

This volume is aimed at researchers in the fields of immunology, genetics, microbiology and medicine who are interested in the detailed mechanisms of the pathogenicity of this carcinogenic stomach bacterium.

Helicobacter pylori and Gastric Cancer

Diagnostic Imaging

Medical Radiology

This volume provides an up-to-date and comprehensive review of Imaging of the Hand and Wrist. In the first part of the book, the various techniques employed when imaging the hand and wrist are discussed in detail. Individual chapters are devoted to radiography, computed tomography, ultrasound and MRI. The second part then highlights the application of these techniques to the diverse diseases encountered in the hand and wrist region. Among the many topics addressed are congenital and developmental abnormalities, trauma, metabolic bone disease, infection, arthritis and tumors.&nbsp; Each chapter is written by an acknowledged expert in the field and a wealth of illustrative material is included. This book will be of great value to radiologists, orthopedic surgeons and other clinicians with an interest in the hand and wrist pathology.

Techniques and Applications

Imaging of the Hand and Wrist

Filling a gap in literature, this book examines surgical trials with a special focus on the underlying principles, challenges, and best practices to successfully conduct rigorous surgical research.While randomized controlled trials (RCTs) remain the gold standard for evaluation of the safety and efficacy of most medical interventions, they are particularly difficult to implement successfully in the context of surgery. As a result, recruitment rates are often extremely low, crossover from non-operative to operative is common, and patients randomly allocated to surgery often simply decline to have the procedure. All of these challenges call into question the recent generalizability and fundamental quality of traditional surgical RCTs. As such, this book explores advanced alternative trial design methods and describes the current regulatory environment around the world. Designed as a practical guide, it is a valuable tool for surgeons, epidemiologist and biostatisticians involved in this challenging field.

Introduction to Surgical Trials

This book takes the reader on an inspiring journey into the immune system, challenging long-held beliefs about immunity. It examines the immune system under historical, philosophical and biological perspectives. It proposes a new way of understanding immunity that goes beyond the binary opposition between self and non-self.Indeed, we, the livings, are chimeras. Mammals, birds, reptiles or fish, insects, spiders or mollusks, plants or algae, we are all made up of a community of living beings who share their lives in the same 'meta-organism'. If we live together, it is because we need each other to live, and if we can live together, it is because an immune system makes it possible, by adapting us to them and by adapting them to us. From this mutual adaptation a new kind of immunity emerges, dynamic, relational, never acquired, an endless immunity. Immunity that this system makes possible is not perfect, far from it, it is a compromise which does not always prevent disease; sometimes it even causes it. Disease is the cost of immunity. Because what the immune system enables is much more essential than the defense of the organism, it is the very existence of the meta-organism that we are. Immunity is more than a protection; it is a condition of existence.With its didactic structure and accessible style, this book is an essential resource for anyone interested in understanding the nature and function of the immune system. It also offers different levels of complexity from which the reader can choose, depending on his or her background, without compromising the main message of the text.&nbsp;With a Foreword from Alfred I. Tauber&nbsp;About the Author:Former Director of the Immunology department of Institute Pasteur in Paris, Marc Daëron, MD, PhD, MPhil, is currently an Inserm emeritus research director at the Centre d’immunologie de Marseille-Luminy, an invited scientist at Institute Pasteur, and an associate member of the Institut d’histoire et de philosophie des sciences et des techniques.

This book takes the reader on an inspiring journey into the immune system, challenging long-held beliefs about immunity. It examines the immune system under historical, philosophical and biological perspectives. It proposes a new way of understanding immunity that goes beyond the binary opposition between self and non-self.Indeed, we, the livings, are chimeras. Mammals, birds, reptiles or fish, insects, spiders or mollusks, plants or algae, we are all made up of a community of living beings who share their lives in the same 'meta-organism'. If we live together, it is because we need each other to live, and if we can live together, it is because an immune system makes it possible, by adapting us to them and by adapting them to us. From this mutual adaptation a new kind of immunity emerges, dynamic, relational, never acquired, an endless immunity. Immunity that this system makes possible is not perfect, far from it, it is a compromise which does not always prevent disease; sometimes it even causes it. Disease is the cost of immunity. Because what the immune system enables is much more essential than the defense of the organism, it is the very existence of the meta-organism that we are. Immunity is more than a protection; it is a condition of existence.With its didactic structure and accessible style, this book is an essential resource for anyone interested in understanding timmunity and the immune system. It offers different levels of complexity from which the reader can choose, depending on his or her background, without compromising the main message of the text.&nbsp;With a Foreword by Alfred I. Tauber

Rethinking the Immune System

Endless Immunity

This comprehensive volume covers all aspects from the historical discovery of the filarial parasite&nbsp;Loa loa&nbsp;to the latest diagnostics and therapies for all forms of pathology used at the point of care. Current developments in these areas are also highlighted. Expert authors present the epidemiological impact of loiasis and the basic mechanisms underlying the disease in native populations and nonresidents of endemic areas. In addition to particulars on the immunology of the parasite, its general and molecular biology, the clinical manifestation is also described in detail. Both common and atypical clinical manifestations are considered. This book concludes with an outlook on further research and targeted eradication of the disease.<div><div> </div>Loa loa, known as the "eye worm", is endemic in the rural populations of several African countries and is transmitted by rainforest deerflies. It displays impressive immune adaptation with a wide range of clinical symptoms that remain largely unexplored. The characteristics of this nematode make it of great interest to physicians and researchers specializing in infectious diseases, epidemiology, and immunology. In addition, students and family physicians working with African immigrants and travelers should know about this parasite.<div> </div><div>Loiasis is a prime example of a neglected disease under the conditions of international health efforts in our globalized world. The present work is intended to promote progress in this field, making it a valuable read within the scope of the UN Sustainable Development Goal 3 (Good Health and Well-Being).</div>
</div>

Loa loa: Latest Advances in Loiasis Research

Dieses kompakte Handbuch bietet einen praxisnahen Überblick über häufige Notfälle in der Orthopädie und basiert auf Unterrichtsmaterial der Universität Rochester. Es richtet sich an medizinisches Fachpersonal ohne orthopädische Ausbildung, z.B. Medizinstudierende, Ärzt*innen aus nicht orthopädischen Fächern, Pflegefachkräften und Physician Assistants, und unterstützt sie bei der Beurteilung und Behandlung dieser Fälle.Oft genügt ein grundlegendes Verständnis der Verletzung und der Behandlungsprioritäten, um eine angemessene Sofortversorgung der Patienten zu ermöglichen, von der diese in hohem Maße profitieren. Mehr als ein Dutzend orthopädischer Notfälle werden in einem leicht verständlichen Format präsentiert, darunter offene Frakturen, Gelenkluxationen, septische Arthritis und das Kompartmentsyndrom. Jedes Kapitel beginnt mit einem klinischen Fallbeispiel und enthält dazu relevante Fragen sowie farbige Abbildungen.Ein ideales Nachschlagewerk für Medizinstudierende, nicht-orthopädische Ärzte, Pflegefachkräfte und Physician Assistants &nbsp;– Notfälle in der Orthopädie ist ein praxisorientierter Leitfaden für den Umgang mit diesen kritischen Situationen. Die Übersetzung wurde mit Hilfe von künstlicher Intelligenz durchgeführt. Eine anschließende menschliche Überarbeitung erfolgte vor allem in Bezug auf den Inhalt. This book is a translation of an original German edition. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation.

Ein Handbuch für Studierende, Ärzte und Ärztinnen, Physician Assistants und Pflegefachkräfte

Notfälle in der Orthopädie

Culinary Medicine is a field of growing interest and importance. Medical doctors are increasingly aware that they have not received adequate training in this field in medical school, residency or fellowship, and patients frequently ask their doctors about appropriate diets for spine and joint conditions. Doctors are often left to "google" the question, shrug their shoulders, or send the patients to nutritionists who don’t have specific training on culinary medicine for spine and joint issues. 

This unique book provides evidence-based clarity on the questions of what food choices are appropriate for promoting and maintaining a healthy musculoskeletal system. The book opens with the essentials of Culinary Medicine, an overview of the anti-inflammatory diet, and the importance of the gut microbiome to overall health and well-being. Subsequent chapters discuss its application to a variety of spine and joint conditions, including degenerative disc disease, spinal stenosis, osteoarthritis, tendinopathies, muscle growth and aerobic workout. Practical pearls are the provided for how to incorporate Culinary Medicine into one's practice.

An Evidence-Based Approach

Culinary Medicine for Spine and Joint Pain

Now in a revised and expanded second edition, this unique book provides a comprehensive review of the unique aspects of adaptive sports medicine and adaptive athletes who are increasingly active and prominent, not only individually and in local leagues and organizations but also in larger settings like the Paralympics and Warrior Games. This book is divided into four thematic sections. Section one covers the history and natural course of the care, policies, and laws for persons with disabilities, as well as the biomechanics and technology of wheelchair sports and adaptive sports prostheses. The medical considerations of the adaptive athlete comprise section two, including epidemiology, emergent care, and surgical and rehabilitative considerations. Section three is the largest section, discussing considerations for specific adaptive sports, including adaptive running, cycling, water sports, throwing sports, wheelchair basketball, softball and rugby, as wellas combative and extreme sports. Selected topics, including event planning, advocacy and controversies such as doping, are covered in section four. Chapters new to this edition include approaches to concussions and sports-related considerations for specific populations like children and adolescents, active duty military and veterans.&nbsp;A comprehensive yet practical text,&nbsp;Adaptive Sports Medicine 2nd Edition&nbsp;remains the go-to resource for this active population and is an invaluable reference for any sports medicine or primary medicine practitioner.

Now in a revised and expanded second edition, this unique book provides a comprehensive review of the unique aspects of adaptive sports medicine and adaptive athletes who are increasingly active and prominent, not only individually and in local leagues and organizations but also in larger settings like the Paralympics and Warrior Games. This book is divided into four thematic sections. Section one covers the history and natural course of the care, policies, and laws for persons with disabilities, as well as the biomechanics and technology of wheelchair sports and adaptive sports prostheses. The medical considerations of the adaptive athlete comprise section two, including epidemiology, emergent care, and surgical and rehabilitative considerations. Section three is the largest section, discussing considerations for specific adaptive sports, including adaptive running, cycling, water sports, throwing sports, wheelchair basketball, softball and rugby, as wellas combative and extreme sports. Selected topics, including event planning, advocacy and controversies such as doping, are covered in section four. Chapters new to this edition include approaches to concussions and sports-related considerations for specific populations like children and adolescents, active duty military and veterans. &nbsp; A comprehensive yet practical text, Adaptive Sports Medicine 2nd Edition remains the go-to resource for this active population and is an invaluable reference for any sports medicine or primary medicine practitioner.

A Clinical Guide

Adaptive Sports Medicine

Skeletal Tissue Mechanics

Infectious Diseases and Arthropods

Bone and Joint Infections

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