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Malignant Bone Lesions and Beyond

Practical Guide to Interventional Radiological Procedures

THE INSTANT SUNDAY TIMES BESTSELLER! 'Only Sophie Kinsella can make you laugh like this while she's got you crying . . . This is one of the gutsiest moves I've seen from a writer in a long time. I could not put it down.' TAYLOR JENKINS REID 'A deeply funny and affecting love story.' The Guardian 'I laughed. And I cried. And then I thought about the meaning of life. A jewel of a book.' JOJO MOYES 'Emotional and affecting, this gave me a new appreciation for life's small joys.' Red 'The bravest book you'll read all year.' JODI PICOULT ------------------ From Number One bestselling author Sophie Kinsella, an unforgettable story - by turns heartbreaking and life-affirming - of a renowned novelist facing a devastating diagnosis and learning to live and love anew. 'What Does It Feel Like? is fiction, but it is my most autobiographical work to date. Eve's story is my story.' - SOPHIE KINSELLA Eve is a successful novelist who wakes up one day in a hospital bed with no memory of how she got there. Her husband, never far from her side, explains that she has had an operation to remove the large, malignant tumour growing in her brain. As Eve learns to walk, talk, and write again - and as she wrestles with her diagnosis, and how and when to explain it to her beloved children - she begins to recall what's most important to her: long walks with her husband's hand clasped firmly around her own, family game nights and always buying that dress when she sees it. Recounted in brief anecdotes, each one is an attempt to answer the type of impossible questions recognizable to anyone navigating the labyrinth of grief. This extraordinary novella is a celebration of life, shot through with warmth and humour - it will both break your heart and put it back together again. 'Why did I write such a personal book? I have always processed my life through writing. Hiding behind my fictional characters, I have always turned my own life into a narrative. It is my version of therapy, maybe. Writing is my happy place, and writing this book, although tough going at times, was immensely satisfying and therapeutic for me.' - SOPHIE KINSELLA ------------------ 'I was gripped and moved and I loved every word.' LISA JEWELL 'A beautiful love story and a glowing beacon of hope.' JENNY COLGAN 'Heartbreaking yet hopeful, this life-affirming read encourages us all to take life by the horns.' Prima 'Of all the books I have read about living with cancer this is by far the best. Beautifully written, profound and deeply moving.' HENRY MARSH Sophie Kinsella, Number 1 Sunday Times bestseller, June 2024 Sophie Kinsella, Sunday Times bestseller, October 2024

What Does it Feel Like?

Time wants you dead. Not just you, but your friends, family, pets - everyone you've ever met...

'A beautifully written book about life and death: busts myths, explores the stories of science and history, and ultimately is rich and uplifting.' Dr Adam Rutherford

With over 17,000 known diseases affecting humans, and countless poisons, carcinogens and toxins in our environment, it's a miracle that our bodies manage to keep us alive. And that is, of course, if they don't betray us themselves, whether through cancers or autoimmune conditions.

Biomedical researcher Professor John Tregoning tells the unlikely story of how, against all odds, we manage to stay alive. Taking an organ-by-organ tour of the human body, Tregoning embarks on his own experimental quest, testing 'life-extending' diets and exercise regimes to separate fact from fad. Exploring the multitude of ways our bodies can kill us, from inherited genetic conditions, through heart attacks, arrythmias and angina, onto the delicate workings of the brain, Live Forever?&nbsp;offers compelling insight into how our bodies work, how we can best look after them - and ultimately live longer, healthier lives.

***

'I heartily recommend this deep dive into wellness... It turns out that none of us are getting out of here alive, but John has bravely put his mind and body on the line to discover the secrets of staying healthy and happy as we get older. A funny, fascinating and educative book.' Ben Willbond, co-creator of Ghosts

'The idea that a book about death and dying could be a delightful read seems ridiculous, and yet John Tregoning has pulled off this trick with humour, flair and elegance.' Nessa Carey, author of The Epigenetics Revolution

'An enjoyable and entertaining mixture of scientific facts about ageing and completely unscientific self-experimentation... recognizing that although none of us will live forever, there are ways we can improve our chances of living well while we are still around.' Dame Sarah Gilbert

A Curious Scientist’s Guide to Wellness, Ageing and Death

Live Forever?

Mitreden im Tumorboard

Onkologie für Viszeral- und Allgemeinchirurgie

This textbook provides a profound overview on comparative oncology covering both the background of the discipline and its underlying principles. It also shows how comparative oncology can be utilized to advance human research. Illustrated by numerous images the book vastly covers current knowledge about comparative aspects of different tumor types such as mammary, prostate or bladder carcinoma. An emphasis is placed on companion animals, but information on other animal models is also included.
In recent years, comparative oncology has become a major topic in human and veterinary medicine. This book now provides a unique and comprehensive look at the field, offering in-depth knowledge to graduate and advanced undergraduate students, as well as researchers working in both fields. Clinicians will particularly appreciate the insights on diagnostics and treatment strategies.

Comparative Oncology

A practical, step-by-step guide to neurointerventional treatment of central nervous system pathology

Case-Based Interventional Neuroradiology, Second Edition, edited by global experts Timo Krings, Adam A. Dmytriw, Sasikhan Geibprasert, and Karel ter Brugge encompasses the entire spectrum of pathological conditions that can be treated by interventional neuroradiologists. The updated second edition of this widely acclaimed resource combines scientific rigor, honesty, and ethics with a human touch throughout significantly expanded content. This includes a growing number of disease entities that can be treated effectively with neurointerventional therapy, such as idiopathic intracranial hypertension, chronic subdural hematoma, retinoblastoma, and cerebrospinal fluid leak.

Throughout 103 cases organized into 10 sections, the authors discuss the rationale for selecting specific materials and methods, then outline the risks and benefits of their choices versus other options. Updated cases include a comprehensive view of endovascular treatment of intracranial aneurysms with and without coiling assistance, flow diversion, and flow disruption. Other major updates include the treatment of shunting lesions, head and neck embolization, spinal pathology, the use of modern stents and liquid embolics. Several case reports describe in detail how to manage asymptomatic, incidentally discovered disorders, highlighting the importance of knowing the natural history of these diseases to formulate the most optimal patient risk management strategy.

Key Highlights

- Reflects the clinical, radioanatomical, technical, and human skills of world-renowned pioneers of neurointerventional techniques, supported by modern disease and imaging leaders

- Insightful clinical pearls on how to avoid, recognize, and manage periprocedural complications

- Interpretation of clinical and high quality imaging findings enhance understanding of the rationale for specific approaches and goals of treatment

This unique book will help fellows and seasoned practitioners in radiology, interventional radiology, neuroradiology, and vascular neurosurgery expand knowledge and understanding of the latest techniques and incorporate them into practice.

Case-Based Interventional Neuroradiology

Clinical Applications of Cancer Genetic Testing

Klinikleitfaden

Gynäkologie und Geburtshilfe Umfassend, leitlinienbasiert und präzise werden alle wesentlichen Bereiche der Gynäkologie und der Geburtshilfe dargestellt inkl. Genetik und Pränataldiagnostik, Neonatologie, gynäkologischer Endokrinologie und gynäkologischer Onkologie. Die Themen sind einheitlich nach Epidemiologie, Klinik, Diagnose, Differenzialdiagnostik, Therapie, Prognose gegliedert und ermöglichen so ein schnelles Nachschlagen im Klinik- und Praxisalltag. NEU in der 12.Auflage: <ul><li>Genitalverstümmelung/Female Genital Mutilation</li><li>FIGO-Klassifikation des Uterus myomatosus</li><li>Behandlung des Hoch- und Kleinwuchses bei Mädchen</li><li>ESHRE-Empfehlungen zur Therapie des polyzystischen Ovarsyndroms</li><li>Nichtvillöse Trophoblasterkrankungen (non-villous GTD)</li><li>Atypisches hämolytisch-urämisches Syndrom (aHUS)/hämolytisch urämisches Syndrom (HUS)</li><li>Umfassende Diagnostik bei Mehrlingsschwangerschaften</li><li>Screeningdiagnostik mit Ultraschall</li></ul> Vollständige Überarbeitung der Themen: <ul><li>Ökonomische und qualitätsbasierte Rahmenbedingungen im Krankenhaus</li><li>Infektionen in Gynäkologie und Geburtshilfe inkl. multiresistenter Erreger</li><li>Management der unterschiedlichen Geburtsphasen</li><li>Endometriose</li><li>Hormonelle Substitution beim Klimakterium</li></ul> Ideal für alle Ärztinnen und Ärzte in der Weiterbildung Gynäkologie und Geburtshilfe, Fachärztinnen und Fachärzte der Gynäkologie und Geburtshilfe sowie für Medizinstudenten und -Studentinnen höherer Semester!

Klinikleitfaden Gynäkologie Geburtshilfe

Individual tumour molecular profiling and tacking dynamic evolution by treatment related selective pressure are crucial for clinical oncology. However, current tissue biopsy cannot represent spatial and temporal tumour heterogeneity due to sampling bias. 

Liquid biopsy is an alternative way of tissue biopsy since it can represent comprehensive molecular signature from multiple distinct lesions and real time tracking is feasible by repeated longitudinal assay during course of treatment.

This book describes current knowledge regarding pre-analytical issues including standardization of blood preparation, analytical variability, clinical application and regulatory agency approval issue, etc. Regarding targets in circulation, it focuses on circulating tumour cells (CTCs), circulating nucleic acid (ctDNA, cell free RNAs), extracellular vesicles, tumour educated platelets, and others (proteins, metabolites).

The book will be a rich source of information and instruction for oncologists and offers stimulating ideas on prospects for further progress in this field.

Current Status and Future Challenges

Liquid Biopsy for Cancer

This is a concise, yet comprehensive book that teaches all essential aspects of the practice of Endobronchial Ultrasound (EBUS) bronchoscopy.

Endobronchial Ultrasound Made Easy

Intracranial Stereotactic Radiosurgery

Provisional text
This book provides a comprehensive review of innovative diagnostic methods for prostate cancer, with a particular emphasis on the development of PET radiopharmaceuticals. The author has had the privilege to introduce several tracers into clinical routine practice, including Na18F, 18F-FCH, 18F-FACBC, 68Ga-PSMA11, 18F-PSMA-1007, and 18F-DCFPyL. Thus, indications in various prostate cancer subgroups are discussed in detail, weighing the pros and cons in clinical practice. In the authors´ practice radiation therapy has been more important and surgical applications; therefore, PET based dose planning is presented in detail. Furthermore, the author has closely followed the development of radiopharmaceutical treatments, particularly in the context of bone pain palliation using radiopharmaceuticals, such as 89SrCl2, 186ReHEDP, 153SmEDTMP, 117mSnDTPA, and 223RaCl2, and targeted treatments (177Lu-PSMSA-617, 177Lu-PSMA-I&amp;T and 225Ac-PSMA).
Thanks to his experience, the author facilitated the set-up of targeted treatments in various countries: Baltic and Nordic countries, elsewhere in Europe, North America (Canada), and Africa (e.g. Ghana). The author's involvement in promoting therapy tourism to Finland further highlights his breadth of knowledge and practical experience.
This book offers valuable insights into the evolving landscape of diagnostic methods and radiopharmaceutical treatments for prostate cancer. With the author's extensive experience and contributions to the field, readers can gain a comprehensive understanding of these advancements and their implications in clinical practice.

A personal Journey

Prostate Cancer from a Nuclear Oncology Perspective

Malignant Bone Lesions and Beyond

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