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Gesamtkatalog

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Leydig Cells

Formation, Regulation and Function in Health and Disease

From Bench to Bedside

Nutritional Neuroscience

Diseases of the Heart, Circulation and Vessels close to the Heart

Clinical Cardiology

From Egg Freezing to Surrogacy, How to Take Charge of Your Body and Your Future

Own Your Fertility

The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity is a critically acclaimed account detailing the groundbreaking discovery of the hormone GLP-1, narrated by the award-winning scientist Professor Jens Juul Holst, along with co-authors Professor Sten Madsbad, Professor Jens Meldgaard Bruun, and Mads Krogsgaard Thomsen, CEO of the Novo Nordisk Foundation. GLP-1 is the hormone found in weight loss medications and diabetes treatments such as Ozempic and Wegovy. The discovery of GLP-1 has significantly transformed treatment options for individuals with type 2 diabetes and obesity, offering benefits that include improved blood glucose regulation and substantial weight loss, while also lowering the risk of related complications. Professor Jens Juul Holst, MD, DMSc, is among the world's leading diabetes researchers, having pioneered the discovery of GLP-1 in the 1980s. In this book, we follow the historical research journey that led to the identification of this hormone, which now signifies a paradigm shift in the management of diabetes and obesity. "The Story of GLP-1: A Historical Journey in the Treatment of Diabetes and Obesity" narrates the rising rates of obesity and diabetes, underscoring a critical public health issue, even in light of considerable progress in treatment alternatives. While traditional approaches, such as low-calorie diets, have shown potential for short-term weight loss, maintaining that loss has proven difficult. Efforts to achieve better blood sugar control have not consistently translated into reduced complications or improved patient outcomes, as demonstrated by extensive international studies. However, the introduction of new diabetes medications, particularly those based on glucagon-like peptide-1 (GLP-1), such as liraglutide and semaglutide, has marked a significant breakthrough. These medications not only improve blood sugar levels but also promote substantial weight loss and reduce cardiovascular complications, offering hope for better management of obesity and diabetes. Despite these promising results, challenges remain regarding accessibility and affordability of these treatments, raising important societal questions about who should receive them and how they should be funded. The author's involvement in the discovery and development of GLP-1 provides a unique perspective on the historical and physiological context of these advancements, making this book a valuable resource for understanding the complexities of metabolic diseases and the evolution of treatment options.

A Historical Journey in the Treatment of Diabetes and Obesity

The Story of GLP-1

A Multidisciplinary Approach to Image-Guided Cancer Therapy

Interventional Oncology

Hot Topics in Physiology

Fetal Metabolic Programming in Obesity and Diabetes: From Mechanisms to Preventive Therapy describes the consequences of cellular and molecular aspects of maternal obesity (before and during pregnancy), diabetes mellitus (pregestational and gestational), and gestational diabesity (i.e., women with pre-pregnancy obesity that developed GDM). The book covers the clinical aspects of mothers and children and the protocols for treating these diseases during pregnancy. Since the patients' clinical information correlates with metabolic parameters at a cellular and systemic level, it covers several pieces of evidence, addressing the pathophysiology of obesity and diabetes in pregnancy. This is an important resource for health professionals, researchers, and postdocs in obesity diabetes, as well as public health, physiology, biochemistry, cell biology, cell physiology, cell metabolism, and clinical medicine.

From Mechanisms to Preventive Therapy

Fetal Metabolic Programming in Obesity and Diabetes

Endocrinology

Neuroendocrine Neoplasia

Pregnancy and the Novel is a study of covert representations of pregnancy and birth in canonical eighteenth- and nineteenth-century novels. The research draws on medical texts to illuminate the ways that novelists simultaneously hide and reveal problematic pregnancies and births. Grounded in narrative theory and historicism, it reveals a reciprocal influence between literature and science through the novels of Samuel Richardson, the Brontës, George Eliot, Dickens and Hardy. This project is an act of literary detective work that will uncover what can easily be missed by twenty-first century readers, bringing it into light by reconstructing historical knowledge of reproductive medicine.This is an open access book.

Detection and Concealment from Richardson to Hardy

The Pregnancy Question and the Novel

Das Transfusionsgesetz (TFG) regelt die Gewinnung von Blut und Blutbestandteilen und die Anwendung von Blut und Blutprodukten. Die dabei einzuhaltenden Standards ergeben sich aus den Hämotherapie-Richtlinien, die aufgrund des Gesetzes erlassen wurden. Der Kommentar gibt allen mit Transfusionsfragen befassten Berufsgruppen einen zuverlässigen Wegweiser durch die einschlägigen Vorschriften an die Hand.

Kommentar zum Transfusionsgesetz (TFG) und den Hämotherapie-Richtlinien

Medical Radiology

Diagnostic Imaging

Measurements in Cardiopulmonary Imaging: When, How, Why

Metabolic Memory: Past, Present and Future Implications delves into the emerging concept of metabolic memory, exploring how our body's metabolic processes retain a 'memory' of past experiences and how this impacts our current and future health. Drawing on the latest scientific research this book aims to bridge the gap between complex scientific concepts and their practical implications for everyday health and wellness. Metabolic memory has profound implications for understanding chronic diseases, particularly diabetes, cardiovascular diseases, and obesity. Despite its significance, there is a lack of comprehensive resource that make this information accessible to both professionals and the general public. This book fills that gap, providing a detailed yet understandable exploration of how past metabolic states influence present and future health outcomes.

Past, Present and Future Implications

Metabolic Memory

In this revolutionary book, Evie Kendal explores the potential that ectogenesis has to promote sexual equality in human reproduction and the role science fiction plays in imagining its realisation.

Reproductive Futures

Science Fiction and the Ethics of Artificial Wombs

Leydig Cells

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