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Heterocyclic Compounds as Pharmaceutical
Ingredients

Heterocyclic Compounds as Pharmaceutical Ingredients

Provides a comprehensive overview of the various diagnosis techniques employed in disease detection and public health crisis management.

Analytical and Chemometric Approaches in Disease Detection and Management

Diagnostic Techniques in Public Health

A Renewable Alternative

Regenerated Cellulose

Pioneers in Arts, Humanities, Science, Engineering, Practice

Julian P. Perry Robinson (1941-2020) made a unique contribution to protecting the world from the misuse of chemistry and biology. A trained chemist and patent lawyer, he applied his specialist knowledge to better understand the nature of chemical and biological warfare (CBW) and how best to prevent this. He pioneered open source methods that enabled him to engage with, and inform, national and international policy making, working across the natural and social sciences, and with diverse sectors, including governments, international organizations, and non-governmental research, advocacy and trade groups. His influence can be seen in the achievement and implementation of the Biological Weapons Convention and Chemical Weapons Convention, and in his influence on CBW scholarship.
This book details his life and work through chapters by people that knew him best – his widow, a close colleague, his son, and a dear friend – alongside reprints of a selection of his publications chosen by his research partners, family and friends, and a bibliography of his CBW writings.

Julian Perry Robinson: Pioneer in the Prohibition of Chemical and Biological Warfare

Updated and expanded information on the properties of pharmaceutical solids and their impact on drug product performance, quality, and stability Solid-State Materials in Pharmaceutical Chemistry provides readers with a comprehensive and up-to-date resource for understanding and controlling the solid-state properties of pharmaceutical materials, enabling the development of safe and effective medicines including small molecule compounds, peptides, proteins, and nucleotides. This new edition covers the significant transformations in the landscape of pharmaceutical research, development, and manufacturing since the previous edition was published, presenting both novel challenges and unprecedented opportunities. New chapters in this edition cover physical and chemical properties of RNA therapeutics, a frontier to many life-saving medicines and vaccines including Covid vaccines, and final stage drug substance manufacturing and control, addressing challenges in API process development including impurity purging, chiral separation, final form preparation, particle size reduction, and nitrosamine control. Readers will also find other updated topics including bulk and surface properties of solids, lipid nanoparticles, applications of pharmaceutical solvates in impurity purging and final form preparation, pharmaceutical cocrystal engineering to enable chiral separation, the emerging technique of microcrystal electron diffraction in solid form characterization, poor wettability of APIs, oral delivery of peptides such as semaglutide, injectable drug-device combination products, and N-nitrosamine control in drug product. This updated and revised Second Edition still features: <ul> <li>Physical and chemical properties of solid-state pharmaceuticals such as amorphous forms, mesophases, polymorphs, hydrates/solvates, salts, co-crystals, nano-particles, and solid dispersions</li> <li>Characterization techniques for solid form identification and physical attribute analysis such as X-Ray powder diffraction, thermal analysis, microscopy, spectroscopy, solid state NMR, particle analysis, water sorption, mechanical property testing, solubility, and dissolution</li> <li>Applications of pharmaceutical chemistry and physical characterization techniques in developing and testing drug substances and drug products for small molecules and biopharmaceuticals</li> </ul> This book is an essential resource on the subject for formulation scientists, process chemists, medicinal chemists, and analytical chemists. The book will also appeal to quality control, quality assurance, and regulatory affair specialists and advanced undergraduate and graduate students in pharmaceutical chemistry, drug delivery, material science, crystal engineering, pharmaceutics, and biopharmaceutics.

Properties, Characterization, and Applications

Solid-State Materials in Pharmaceutical Chemistry

Spectrophotometry in Food Analysis: Fundamentals, Applications and Methods is an indispensable resource for anyone involved in food analysis. This comprehensive book offers a detailed exploration of analytical techniques and methodologies pivotal to the food industry. Combining a solid overview of fundamental principles with practical case studies, it guides readers through the intricacies of spectroscopic and spectrophotometric analysis. From instrumentation to laboratory techniques, this book covers all essential aspects, making it a must-read for students, researchers, and professionals aiming to enhance their understanding and application of these techniques. The book is systematically divided into nine sections, beginning with a broad overview of spectrophotometry. It progresses to practical applications in food quality, safety, traceability, and characterization, with specific sections dedicated to Raman, Near-Infrared, and FTIR spectroscopy. Each section is enriched with real-world examples, method validations, and troubleshooting tips, ensuring readers gain a robust understanding of the subject. This book is particularly valuable for chemists, food technologists, and laboratory technicians, but also serves as a useful guide for newcomers and interdisciplinary researchers interested in food analysis.

Fundamentals, Applications and Methods

Spectrophotometry in Food Analysis

Wiley Series on Mass Spectrometry

This book encompasses topics from the fundamentals of disease related protein misfolding and mass spectrometry, to current research highlights in these areas. It is aimed to provide an overview of this rapidly developing field in order to present a good mixture of information that will encourage people to participate in, and further the use of mass spectrometry in studying protein misfolding with biologically relevant applications. Using examples from the current literature, the book focuses on details relating to understanding the fundamentals of disease related protein misfolding, conducting and optimising the mass spectrometry experiment, and also future prospects of methodologies within this rapidly evolving and topical research area.

Using current examples and high-quality illustrations, this book covers topics including how to conduct and optimize experiments; the structural and atomic level information afforded by mass spectrometry in disease related protein systems, and incorporates future research prospects.

Insights from Mass Spectrometry

Protein Misfolding, Aggregation and Disease

Properties and Applications of Advanced Materials

Organic Reactions

A carefully curated review of the scientific literature, Volume 118 of Organic Reactions presents critical discussions of widely used organic reactions or particular steps of a reaction. The material is treated from a preparative viewpoint, with emphasis on limitations, interfering influences, effects of structure and the selection of experimental techniques. The work includes tables that contain all possible examples of the reaction under consideration. Detailed procedures illustrate the significant modifications of each method. Launched in 1942, the Organic Reactions series today is a leading secondary- and tertiary-level source for organic chemists across the world.

Organic Reactions, Volume 118

Volume 1: Herbicides

Modern Crop Protection Compounds

Chemistry, Synthesis, and Applications

Handbook of Perovskites

Chemistry and Essential Applications

Polymers in Functional Foods and Drugs

Molecular Collisions and Gaseous Kinetics covers elastic collisions, inelastic collisions leading to energy transfer and electronic transitions, reactive collisions, and photoinduced dynamics. Collisions with surfaces, thermal rates of those phenomena, as well as transport and relaxation phenomena mediated by molecular collisions are also discussed. A final chapter on many-atom scattering theory serves as an introduction to more advanced descriptions. The treatment is based on the quantal theory of scattering and its semiclassical limits, introduces realistic intermolecular forces, and includes computational aspects needed to calculate cross-sections and compare them with experimental data. It is motivated by a need to cover these subjects starting from the electronic structure and atomic conformation of molecules. The chapters provide an introduction to experimental methods where appropriate, and connect theory to applications for specific physical systems to obtain results that can be compared to experimental data.

Energy Transfer and Reactivity

Quantum Molecular Dynamics

Heterocyclic Compounds as Pharmaceutical Ingredients

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