This book describes the complete design of CMOS-based multi-nuclear NMR/MRI microsystems. The authors emphasize optimizing semiconductor chip design to enhance the performance of compact CMOS-based NMR/MRI systems. They also discuss the integrated circuit design of customized modules, such as 3-D gradient controllers specifically for MRI, high-resolution multi-phase generators for advanced composite radio-frequency excitation pulse synthesis, etc. The integration of these specific modules not only drives system innovation but also expands functionality.