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Schwarcz J: An Apple A Day / LF

An Apple A Day

New York Times bestselling author and former FDA Commissioner Scott Gottlieb provides a glimpse of a promising future that is quickly approaching: a world with cures for chronic illnesses and cancers. While traditional drugs mostly help us manage the effects of disease, cell therapies promise genuine cures for a broad range of intractable ailments, from Alzheimer's to heart damage to cancer. They could even reverse the effects of aging. For the first time in history, on an unprecedented scale, we possess the power to modify the biology that gives rise to disease, ultimately restoring individuals to a state of normalcy and reversing debilitating ailments. In The Miracle Century, former FDA Commissioner Scott Gottlieb traces the scientific achievements that propelled progress in cell therapies. The birth of this medical revolution wasn't a sudden event. Rather, it emerged from decades of steady, incremental progress in science. These concerted advances made cell therapies a reality. To forge a path for continued medical breakthroughs, Dr. Gottlieb meticulously traces this scientific journey, identifying lessons on how these achievements can be replicated. The MIracle Century is a look at the future of healthcare from one of the nation's leading medical authorities. Scott Gottlieb explains how these new medicines are moving from the laboratory bench to the marketplace and tackles the issues that must be addressed to enable wide adoption of these treatments and transform as many lives as possible.

Making Sense of the Cell Therapy Revolution

The Miracle Century

"An investigative reporter uncovers corruption in the pharmaceutical industry"--

How Big Pharma Misleads, Obscures, and Prevails

Follow the Science

In this eye-opening chronicle of the scientific research and experiments into the brain during the Cold War era, acclaimed historian Andreas Killen identifies both the genesis of and instigator for our continued fascination.While America flourished in the golden years of the 1950s, the decade was also marked by intense paranoia and social anxiety. It was a period in which intense pressures brought to bear on individuals and societies converged in remarkable ways with landmark developments in the sciences of brain and behavior.In this mind-expanding book, Andreas Killen looks at the Laurentian Symposium, an international meeting of neuroscientists who met to discuss breakthroughs challenging then commonly held ideas about the relationship between brain and mind. Like Alice going through the looking glass, experiments with electrical stimulation of the brain, flicker, sensory deprivation, mescal, hypnosis, and word association were opening portals to strange realms, and seemed to point to evidence of decoupling or dissociation of different brain systems connected to consciousness. Killen puts these experiments into perspective, revealing how they were conducted at a time not only of revolutionary developments in brain science but when scientists were obsessed with the altered states of consciousness experienced by POWs undergoing interrogation and individuals subjected to the ?bombardment? of the mass media.A recent account of developments in brain science during the 1950s called it the most revolutionary decade in the history of the field, during which the essential foundations for the field of modern neuroscience were laid. But did the participants in this symposium see themselves as revolutionaries? Killen shows how a new boldness marked the investigations of that era, and how those mid-century scientists opened pathways to the future?even while that future was veiled in uncertainty driven by ominous geopolitical events. Nervous Systems explores this critical time and the fraught political and social context in which mid-century sciences of the brain and behavior took shape.

Brain Science in the Early Cold War

Nervous Systems

New from the author of the acclaimed bestseller The Rise and Fall of the Dinosaurs (?A masterpiece of science writing.? ?Washington Post) and ?one of the stars of modern paleontology? (National Geographic), a sweeping and revelatory history of mammals, illuminating the lost story of the extraordinary family tree that led to us.We humans are the inheritors of a dynasty that has reigned over the planet for nearly 66 million years, through fiery cataclysm and ice ages: the mammals. Our lineage includes saber-toothed tigers, woolly mammoths, armadillos the size of a car, cave bears three times the weight of a grizzly, clever scurriers that outlasted Tyrannosaurus rex, and even other types of humans, like Neanderthals. Indeed humankind and many of the beloved fellow mammals we share the planet with today?lions, whales, dogs?represent only the few survivors of a sprawling and astonishing family tree that has been pruned by time and mass extinctions. How did we get here?In his acclaimed bestseller The Rise and Fall of the Dinosaurs?hailed as ?the ultimate dinosaur biography? by Scientific American?American paleontologist Steve Brusatte enchanted readers with his definitive history of the dinosaurs. Now, picking up the narrative in the ashes of the extinction event that doomed T-rex and its kind, Brusatte explores the remarkable story of the family of animals that inherited the Earth?mammals? and brilliantly reveals that their story is every bit as fascinating and complex as that of the dinosaurs.Beginning with the earliest days of our lineage some 325 million years ago, Brusatte charts how mammals survived the asteroid that claimed the dinosaurs and made the world their own, becoming the astonishingly diverse range of animals that dominate today's Earth. Brusatte also brings alive the lost worlds mammals inhabited through time, from ice ages to volcanic catastrophes. Entwined in this story is the detective work he and other scientists have done to piece together our understanding using fossil clues and cutting-edge technology.A sterling example of scientific storytelling by one of our finest young researchers, The Rise and Reign of the Mammals illustrates how this incredible history laid the foundation for today's world, for us, and our future.

A New History, from the Shadow of the Dinosaurs to Us

The Rise and Reign of the Mammals

The scientist known as the ?space mechanic? administers to both our future and past in this breathless memoir of his journey from Ecuador to NASA and beyond.Elio Morillo's life is abruptly spun out of orbit when economic collapse forces his family to flee Ecuador for the United States. His itinerant childhood sets into motion a migration whose momentum will ultimately carry Elio to the farthest expanse of human endeavor: space.Overcoming a history of systemic adversity and inequality in public education, Elio forged ahead on a journey as indebted to his galactic dreams as to a loving mother whose sacrifices provided the ground beneath his feet. Today, Elio is helping man NASA's mission to explore Mars and promoting the future of human innovation?from AI and robotics to space infrastructure and equitable access.The Boy Who Reached the Stars is both a cosmic and intimate memoir spun from a constellation of memory and intrepid curiosity, as thoroughly luminous as the stars above.

A Memoir

The Boy Who Reached for the Stars

Harvard's acclaimed geologist ?charts Earth's history in accessible style? (AP)?A sublime chronicle of our planet." ?Booklist, STARRED reviewHow well do you know the ground beneath your feet? Odds are, where you're standing was once cooking under a roiling sea of lava, crushed by a towering sheet of ice, rocked by a nearby meteor strike, or perhaps choked by poison gases, drowned beneath ocean, perched atop a mountain range, or roamed by fearsome monsters. Probably most or even all of the above. The story of our home planet and the organisms spread across its surface is far more spectacular than any Hollywood blockbuster, filled with enough plot twists to rival a bestselling thriller. But only recently have we begun to piece together the whole mystery into a coherent narrative. Drawing on his decades of field research and up-to-the-minute understanding of the latest science, renowned geologist Andrew H. Knoll delivers a rigorous yet accessible biography of Earth, charting our home planet's epic 4.6 billion-year story. Placing twenty first-century climate change in deep context, A Brief History of Earth is an indispensable look at where we've been and where we're going.Features original illustrations depicting Earth history and nearly 50 figures (maps, tables, photographs, graphs).

Four Billion Years in Eight Chapters

A Brief History of Earth

The New York Times bestselling author of Stuff Matters and Liquid Rules presents a fascinating guided tour of the secret life of gases: the strange, elusive, and fascinating substances that shape our world. Gases are all around us?they fill our lungs, power our movement, create stars, and warm our atmosphere. Often invisible and sometimes odorless, these ubiquitous substances are also the least understood materials in our world, and always have been. It wasn't long ago that they were seen as the work of ancient spirits: the sudden closing of a door after a change in airflow signaled a ghost's presence. Scientists and engineers have struggled with their own gaseous demons. The development of high-pressure steam power in the 18th century literally blew away some researchers, ushering in a new era for both safety regulations and mass transit. And carbon dioxide, that noxious byproduct of fossil fuel consumption and cow burps, gave rise to modern civilization. Its warming properties known for centuries, it now spells ruin for our fragile atmosphere. As bestselling science writer and materials scientist Mark Miodownik shows in this entertaining, often hilarious tour of gases, we've long harnessed the power of gases to create life-altering technologies, without fully understanding their potential.In the perfect follow-up to his bestselling Stuff Matters and Liquid Rules, It's a Gas chronicles ten gases that shaped human history. From hydrogen, carbon dioxide, and neon to laughing gas, steam, and even wind, the story of gases is the story of that tricky space where science and belief collide, and of the elusive limits of human understanding.

The Sublime and Elusive Elements That Expand Our World

It's A Gas

In this eye-opening chronicle of scientific research on the brain in the early Cold War era, the acclaimed historian Andreas Killen traces the complex circumstances surrounding the genesis of our present-day fascination with this organ. The 1950s were a transformative, even revolutionary decade in the history of brain science. Using new techniques for probing brain activity and function, researchers in neurosurgery, psychiatry, and psychology achieved dramatic breakthroughs in the treatment of illnesses like epilepsy and schizophrenia, as well as the understanding of such faculties as memory and perception. Memory was the site of particularly startling discoveries. As one researcher wrote to another in the middle of that decade, "Memory was the sleeping beauty of the brain-and now she is awake." Collectively, these advances prefigured the emergence of the field of neuroscience at the end of the twentieth century. But the 1950s also marked the beginning of the Cold War and a period of transformative social change across Western society. These developments resulted in unease and paranoia. Mysterious new afflictions-none more mystifying than "brainwashing"-also appeared at this time. Faced with the discovery that, as one leading psychiatrist put it, "the human personality is not as stable as we often assume," many researchers in the sciences of brain and behavior joined the effort to understand these conditions. They devised ingenious and sometimes transgressive experimental methods for studying and proposing countermeasures to the problem of Communist mind control. Some of these procedures took on a strange life of their own, escaping the confines of the research lab to become part of 1960s counterculture. Much later, in the early 2000s, they resurfaced in the War on Terror. These stories, often told separately, are brought together by the historian Andreas Killen in this chronicle of the brain's mid-twentieth-century emergence as both a new research frontier and an organ whose integrity and capacities-especially that of memory-were imagined as uniquely imperiled in the 1950s. Nervous Systems explores the anxious context in which the mid-century sciences of the brain took shape and reveals the deeply ambivalent history that lies behind our contemporary understanding of this organ.

“Page for page, I may not have ever learned more from a book.... Womb is a history book as well as a biology book but it’s also an adventure and a celebration.” —Rob Delaney, actor and author of A Heart That WorksA groundbreaking, triumphant investigation of the uterus—from birth to death, in sickness and in health, throughout history and into our possible future—from midwife and acclaimed writer Leah HazardThe size of a clenched fist and the shape of a light bulb—with no less power and potential. Every person on Earth began inside a uterus, but how much do we really understand about the womb?Bringing together medical history, scientific discoveries, and journalistic exploration, Leah Hazard embarks on a journey in search of answers about the body’s most miraculous and contentious organ. We meet the people who have shaped our relationship with the uterus: doctors and doulas, yoni steamers and fibroid-tea hawkers, legislators who would regulate the organ’s very existence, and boundary-breaking researchers on the frontiers of the field.With a midwife’s warmth and humor, Hazard tackles pressing questions: Is the womb connected to the brain? Can cervical crypts store sperm? Do hysterectomies affect sexual pleasure? How can smart tampons help health care? Why does endometriosis take so long to be diagnosed? Will external gestation be possible in our lifetime? How does gender-affirming hormone therapy affect the uterus? Why does medical racism impact reproductive healthcare?A clear-eyed and inclusive examination of the cultural prejudices and assumptions that have made the uterus so poorly understood for centuries, Womb takes a fresh look at an organ that brings us pain and pleasure—a small part of our bodies that has a larger impact than we ever thought possible.&nbsp;

The Inside Story of Where We All Began

Womb

"A profoundly illuminating account of how the brain works . . . Rebecca Schwarzlose is a neuroscientist with a novelist's literary flair." -Cass R. Sunstein, author of Too Much Information A path-breaking journey into the brain, showing how perception, thought, and action are products of maps etched into your gray matter-and how technology can use them to read your mind Your brain is a collection of maps. That is no metaphor: scrawled across your brain's surfaces are actual maps of the sights, sounds, and actions that hold the key to your survival. Scientists first began uncovering these maps over a century ago, but we are only now beginning to unlock their secrets-and comprehend their profound impact on our lives. Brain maps distort and shape our experience of the world, support complex thought, and make technology-enabled mind reading a modern-day reality, which raises important questions about what is real, what is fair, and what is private. They shine a light on our past and our possible futures. In the process, they invite us to view ourselves from a startling new perspective. ​ In Brainscapes, Rebecca Schwarzlose combines unforgettable real-life stories, cutting-edge research, and vivid illustrations to reveal brain maps' surprising lessons about our place in the world-and about the world's place within us.

The Warped, Wondrous Maps Written in Your Brain—And How They Guide You

Brainscapes

"A riveting tour of the cosmos from one of the brightest minds in astrophysics." ?The Washington PostA revolutionary new account of our universe's creation?and a breathtaking exploration of the landscape from which we sprang?from one of the world's most celebrated cosmologistsWhat came before the Big Bang, and what exists outside of the universe it created? Until recently, scientists could only guess at what lay past the edge of space-time. However, as pioneering theoretical physicist Laura Mersini-Houghton explains, new scientific tools are now giving us the ability to peer beyond the limits of our universe and to test our theories about what is there. And what we are finding is upending everything we thought we knew about the cosmos and our place in it.Mersini-Houghton is no stranger to boundaries?or to pushing through them. As a child growing up in Communist Albania, she discovered a universe beyond her walled-off world through the study of math and science, and through music. As a female cosmologist in a male-dominated field, she transcended the limits that society and her profession tried to place on her. And as a trailblazing researcher, she helped to revolutionize the study of our universe by revealing that, far from living in a cosmic Albania, with a world that ends at its borders, we are part of a larger family of universes?a multiverse?that holds wonders we are only beginning to unlock. Mersini-Houghton's groundbreaking research suggests that we sit in a quantum landscape whose peaks and valleys hide a multitude of other universes, and even hold the secret to the origins of existence itself. Recent evidence has revealed the signatures of such sibling universes in our own night sky, confirming Mersini-Houghton's theoretical work and offering humbling evidence that our universe is just one member of an unending cosmic family.The incredible scientific saga of one woman's mind-expanding journey through the multiverse, Before the Big Bang will reshape our understanding of humanity's place in the unfathomable vastness of the cosmos.

The Origin of Our Universe from the Multiverse

Before the Big Bang

For readers of Bill Bryson, Neil deGrasse Tyson and Siddhartha Mukherjee, a wondrous, wildly ambitious, and vastly entertaining work of popular science that tells the awe-inspiring story of the elements that make up the human body, and how these building blocks of life travelled billions of miles and across billions of years to make us who we are.Every one of us contains a billion times more atoms than all the grains of sand in the earth's deserts. If you weigh 150 pounds, you've got enough carbon to make 25 pounds of charcoal, enough salt to fill a saltshaker, enough chlorine to disinfect several backyard swimming pools, and enough iron to forge a 3-inch nail. But how did these elements combine to make us human? All matter?everything around us and within us?has an ultimate birthday: the day the universe was born. This informative, eye-opening, and eminently readable book is the story of our atoms' long strange journey from the Big Bang to the creation of stars, through the assembly of Planet Earth, and the formation of life as we know it. It's also the story of the scientists who made groundbreaking discoveries and unearthed extraordinary insights into the composition of life. Behind their unexpected findings were investigations marked by fierce rivalries, obsession, heartbreak, flashes of insight, and flukes of blind luck. Ultimately they've helped us understand the mystery of our existence: how a quadrillion atoms made of particles from the Big Bang now animate each of our cells.Shaped by the curious mind and bold vision of science and history documentarian Dan Levitt, this wondrous book is no less than the story of life itself.

The Story of Your Body's Atoms, from the Big Bang Through Last Night's Dinner

What's Gotten Into You

An Apple A Day

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