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Alternative Splicing and Cancer

Cases that Changed the World

The Secrets of our DNA

Structural Biology of Amyloid Fibrils is a comprehensive reference on the structure of protein aggregates in different neurodegenerative diseases and their molecular bases. Chapters describe these structures in detail, highlighting their similarities and differences across different disease states, alongside an unprecedented overview of current developments and new hypotheses emerging in amyloid fibril structure, stability and mechanisms of formation. This volume also discusses how amyloid structure may affect the ability of fibrils to spread to different sites in a prion-like manner, as well as their role in disease. Featuring chapters on NMR, X-ray crystallography, and Cryo-EM methods, and discussing the structure of amyloid fibrils obtained directly from patients, the book allows readers to understand how polymorphism is associated with disease phenotype and how fibril structure affects and influences the cellular environment. Understanding the molecular architecture of amyloid fibrils and oligomers will be an important step towards developing therapeutic interventions based on targeting the fibrils and oligomers themselves, or the processes that generate them.

Structural Biology of Amyloid Fibrils

Gestational Diabetes Mellitus: Epidemiology, Clinical Practice and Evidence-Based Guidelines is an invaluable resource for healthcare professionals seeking to understand the latest developments in GDM. Over the past 20 years, significant progress has been made in the study of its epidemiology, mechanisms, diagnosis, management, and prevention. This book delves into these advancements, offering insights that are crucial for both researchers and clinicians. It explores potential therapeutic solutions to enhance patient care, and is essential reading for obstetricians, endocrinologists, diabetes researchers, maternal health specialists, and pediatric endocrinologists, as well as specialty fellows, residents, postdoctoral fellows, and graduate students in these fields.

Epidemiology, Clinical Practice and Evidence-Based Guidelines

Gestational Diabetes Mellitus

One man’s adventures in cancerland

The Leopard in my House

Aortic Valve Repair provides a comprehensive summary on techniques developed during the first 500 cases of aortic ring annuloplasty. Aortic valve disease is usually surgically managed by aortic valve replacement, and it is well established in published literature regarding the long-term results, survival rate, durability of the protheses and reoperations rates. Over the past two decades, aortic valve repair (AVr) has evolved into a recognized surgical option for selected patients with aortic insufficiency or proximal aorta aneurysm. Studying the first 500 cases of aortic ring annuloplasty, the authors provide the most effective methods of leaflet and aortic root reconstruction to repair pathologies. Including original illustrations and videos, the book serves as an essential reference for cardiac surgeons in practice.

Aortic Valve Repair

Biofeedback and Pain Management: A Clinical Guide is a practical and informative reference to help readers have a better understanding of the psychophysiology of chronic pain, biofeedback treatments, realities of living life with chronic limitations related to pain, and the role of pain in our lives and society. The book aims to organize available evidence on effective uses of biofeedback interventions for pain management, including protocols, as well as case-based examples and strategies that practitioners can refer to in real-life settings. Biofeedback and Pain Management is organized into three sections. In the first section, "Psychophysiology of Pain," a clear treatment rationale for the use of biofeedback is illustrated, including patient-friendly language about what is biofeedback and illustrations depicting how biofeedback is a useful part of any pain management treatment plan. In the next section, "Biofeedback Protocols," procedures are detailed based on evidence as well as case-based examples. This section is the heart of the book and offers essential strategies that readers can refer to on an as-needed basis. The final section, "Community Pain," explores the larger social context of chronic pain, the toll it has on public health and the ongoing role of healthcare providers who witness pain-related suffering.

A Clinical Guide

Biofeedback and Pain Management

The dinosaur-bird transition has been intensively studied using both fossil and embryological evidence. In recent years, the notion that birds are living dinosaurs has become the mainstream opinion in paleontology. But some embryologists and ornithologists remain skeptical and accuse paleontologists of ignoring conflicting evidence. This book resolves these conflicts. Careful re-evaluation of those features in seeming contradiction reveal that such characteristics actually support and corroborate the mainstream view that birds are in fact members of a dinosaurian lineage - they are living dinosaurs.

Interpreting and Resoliving Developmental Evidence

Embryos of Living Dinosaurs

Approaches and Technologies

Human-Centred AI For Intelligent Healthcare

Matters of the Image introduces a new framework for thinking about digital images.

Designing Digital Images with Materiality, Energy, and Living Matter

Glial Mechanisms in Sleep and Circadian Biology presents a comprehensive and up-to-date discussion of the role of glial cells in numerous, often unexpected, aspects of sleep. It seamlessly links glial cell activity to the multi-system processes that affect sleep. Experts in the field discuss how glial cells influence the sleep-wake cycle, the accumulation and discharge of sleep drive, the timing of sleep and wake across the 24-hour day, and how glial cells may govern important sleep functions (e.g., brain plasticity and metabolism). This is a book that could well change scientists’ and practitioners’ traditional beliefs about the factors underlying sleep. Users will find the book's content at the forefront of one of the hottest topics in basic sleep research. Over the last decade, scientists have made breakthrough discoveries revealing that sleep is not only a product of neurons, but of neuronal-glial interactions.

Glial Mechanisms in Sleep and Circadian Biology

Fluid Dynamics of Viral Transmission is an essential exploration into the transmission dynamics of COVID-19, focusing specifically on the airborne spread of respiratory aerosols carrying infectious viruses. In light of the recent global pandemic, it offers crucial insights into the complex interaction between fluid dynamics and viral transmission and provides practical solutions for minimizing risks in indoor environments. The book delves into CFD simulations, optimizing ventilation systems, air filtration strategies, and spatial layout modifications. It evaluates mitigation measures such as mask-wearing, physical distancing, and occupancy limits, aiming to equip readers with the knowledge to create safer indoor spaces. This book is ideal for public health officials, policymakers, healthcare professionals, engineers, researchers, and academics in fluid mechanics, computational fluid dynamics, epidemiology, and virology.

Fluid Dynamics of Viral Transmission

Foundations and Frontiers in Enzymology

Enzyme Kinetics: Fundamentals, Applications, and Reactor Design is a comprehensive guide that provides readers with a solid grounding in the principles of enzyme kinetics and bioreactor design while also illuminating their practical applications. The book takes a step-by-step approach, starting from basic concepts and gradually moving to advanced topics, to ensure that readers develop a strong understanding and are well-equipped to apply this knowledge in real-world scenarios. "Enzyme Kinetics: Fundamentals, Applications, and Reactor Design" covers crucial areas including safety regulations and future trends, making it an all-in-one resource for anyone interested in these fields. It also provides foundational information, explains methods and computational approaches, and presents case studies and applications. This book is designed to serve as a valuable resource for a broad range of readers, including undergraduate and graduate students studying biochemistry, biotechnology, and chemical engineering, as well as professionals and researchers looking to deepen their knowledge and stay at the forefront of their field. Enzyme Kinetics: Fundamentals, Applications, and Reactor Design offers an integrative and up-to-date perspective on enzyme kinetics and bioreactor design, with an emphasis on real-world applications, cutting-edge developments, and safety regulations.

Fundamentals, Applications, and Reactor Design

Enzyme Kinetics

Alternative Splicing and Cancer

Informations bibliographiques

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