Translational Models of Parkinson’s Disease and related Movement Disorders

The second most prevalent neurodegenerative ailment after Alzheimer's disease is Parkinson's disease, characterized by midbrain dopaminergic neuron loss and age-dependent motor impairment. To make Parkinson's disease risk predictable and manageable, experimental investigations based epidemiological and genetic studies are crucial. Translational Models of Parkinson¿s Disease and Related Movement Disorders focuses on cutting-edge techniques for creating and validating current Parkinson¿s Disease translational experimental models. Various characteristics of these models are examined, including the prion-like properties of -synuclein, mitochondrial functions connected to the PINK1-Parkin pathway/CHCHD2, the endolysosome pathway connected to LRRK2, VPS35, and ATP13A2 using cultured cells (including patient iPS cells). This book will also highlight the future possibilities of introducing new models for Parkinson¿s Disease and related movements disorders. It will underscore the current advancements, pre-clinical and clinical development, and future scope related to numerous models.